Anti-proliferative Effects of Atractylis lancea (Thunb.) DC. via Down-regulation of the c-myc/hTERT/Telomerase Pathway in Hep-G2 Cells

Telomerase reverse transcriptase suppression inhibits cell proliferation and promotes cell apoptosis in hepatocellular cancer

“…It has been reported that cancer cells are often defective in cell cycle checkpoint mechanisms . The chromosome fusions loss, cell cycle arrest, and apoptosis in human somatic cells were induced by telomerase shortenings . Therefore, our study was aimed at investigating HCC cell proliferation and apoptosis regulated by TERT in HCC cells and our study may provide novel therapy insights for HCC treatment.…”

Therapeutic strategies for targeting telomerase in cancer

“…Data from clinical trials also showed that OB‐301 showed strong activity against a human soft tissue sarcoma (STS) cell line . In addition, Lin et al tested the oncolytic effect of OB‐301 on HCC in vivo using an orthotopic HCC animal model; the results showed that it was a safe and effective treatment for HCC . A similar drug is Telome Scan (OBP‐401), which is an improvement of OBP‐301 .…”

“…In addition, Lin et al tested the oncolytic effect of OB‐301 on HCC in vivo using an orthotopic HCC animal model; the results showed that it was a safe and effective treatment for HCC . A similar drug is Telome Scan (OBP‐401), which is an improvement of OBP‐301 . Further studies with OB‐301 or OBP‐401 may be required to fully assess their safety and efficacy.…”

“…Here, we collect natural telomerase inhibitors reported in the literature and summarize their telomerase inhibition effects, structures, possible mechanisms, and provide references for pharmaceutical chemists searching for suitable lead compounds. Table and Figures and show natural products and chemical structures that target the telomere elongation process …”

Liposome-mediated Induction of Apoptosis of Human Hepatoma Cells by C-Myc Antisense Phosphorothioate Oligodeoxynucleotide and 5-Fluorouracil

“…As an important medicinal herb, Atractylis lancea (Thunb.) has been demonstrated with anti-proliferative effects in Hep-G2 cells via down-regulation of the c-myc/ hTERT/telomerase pathway (Guo et al, 2013). Some studies showed that antisense oligodeoxynucleotide (ASODN) aiming at c-myc could significantly decrease the expression of c-myc both at mRNA and protein levels, inhibit proliferation of cancer, induce apoptosis and increase the sensitivity of cancer cells to chemotherapy (Hayashi et al, 1994, Jin et al, 2002.…”