Anti-proliferative effect of chitosan nanoparticles (extracted from crayfish Procambarus clarkii, Crustacea: Cambaridae) against MDA-MB-231 and SK-BR-3 human breast cancer cell lines

Taher, Fatma A.; Ibrahim, Sherif; El-Aziz, Ahmed Abd; El-Nour, Mohamed F. Abou; El-Sheikh, Mostafa A.; El-Husseiny, Noura; Mohamed, Mona Mostafa

doi:10.1016/j.ijbiomac.2018.12.151

Cited by 36 publications

(34 citation statements)

References 32 publications

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“…Krausz et al [ 80 ] report the enhancement of the antimicrobial and wound healing activity of encapsulated curcumin, while the research of Kavaz et al [ 81 ] showed that the encapsulation of Cyperus articulates EO enhanced the antibacterial activity against Staphylococcus aureus (ATCC6538) and Escherichia coli (ATCC 8739) and the in vitro cytotoxicity against MDA-MB-231 breast cancer cells. Taher et al [ 82 ], verified the higher in vitroanti-proliferative effect of chitosan nanoparticles against two different human breast cancer lines compared to microparticles.…”

Section: Chitosan As a Matrix For Nanosystemspreparation: Methodsmentioning

confidence: 99%

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

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Chitosan is a cationic natural polysaccharide, which has emerged as an increasingly interesting biomaterialover the past few years. It constitutes a novel perspective in drug delivery systems and nanocarriers’ formulations due to its beneficial properties, including biocompatibility, biodegradability and low toxicity. The potentiality of chemical or enzymatic modifications of the biopolymer, as well as its complementary use with other polymers, further attract the scientific community, offering improved and combined properties in the final materials. As a result, chitosan has been extensively used as a matrix for the encapsulation of several valuable compounds. In this review article, the advantageous character of chitosan as a matrix for nanosystemsis presented, focusing on the encapsulation of natural products. A five-year literature review is attempted covering the use of chitosan and modified chitosan as matrices and coatings for the encapsulation of natural extracts, essential oils or pure naturally occurring bioactive compounds are discussed.

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Section: Chitosan As a Matrix For Nanosystemspreparation: Methodsmentioning

confidence: 99%

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

et al. 2020

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“…Chitosan derivatives can be used as targeted delivery vehicles for drugs, as well as adjuvants and delivery carriers for vaccines [14][15][16][17][18][19][20]. Therefore, chitosan derivatives and their nanomaterials can be widely used and expanded upon in terms of the fields of chitosan application [21,22]. The properties of materials determine their applications, so this review focuses on the preparation of chitosan derivatives with excellent solubility, pH sensitivity, targeting, and mucosal adhesion; additionally, this review introduces the application fields of chitosan derivatives in medicine in three aspects, namely as drug carriers, drug materials, and for mucosal immunity.…”

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confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

514

260

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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“…Zelbielca et al showed that combined exposure of nanoparticles of doxorubicin/GSH has higher cytotoxic effects than free doxorubicin in feline fibrosarcoma cell lines [20]. In a study in MCF-7 cells with metallic nanoparticles and radiation, there was a higher effect on the combination exposure, acting nanoparticles as nano-sensitizers [34].…”

Section: Glutathione Reductase Activitymentioning

confidence: 99%

Chitosan-Glutathione nanoparticles modify oxidative stress induced by doxorubicin in breast cancer cells

López-Barrera¹,

Díaz-Torres²,

Martínez-Rosas³

et al. 2020

Preprint

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Doxorubicin is a widely used antineoplastic agent for the treatment of various types of cancer. However, it is also a highly toxic drug because it induces the generation of oxidative stress. Thus, the use of antioxidant molecules has been considered to reduce the toxicity of doxorubicin. In this report, we investigated whether the use of chitosan-glutathione (CH-GSH) nanoparticles could reduce cell damage induced by doxorubicin on breast cancer cells. CH-GSH NPs were characterized in size, Zeta potential, concentration, and shape. When breast cancer cells were treated with CH-GSH nanoparticles, these were localized in the cellular cytoplasm. Combined exposure of doxorubicin and nanoparticle increased intracellular GSH levels while decreasing reactive oxygen species and malondialdehyde levels. The antioxidant enzyme activity was also decreased. Together our data suggest that the use of CH-GSH nanoparticles can reduce the oxidative stress induced by doxorubicin on breast cancer cells.

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Anti-proliferative effect of chitosan nanoparticles (extracted from crayfish Procambarus clarkii, Crustacea: Cambaridae) against MDA-MB-231 and SK-BR-3 human breast cancer cell lines

Cited by 36 publications

References 32 publications

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix

Chitosan Derivatives and Their Application in Biomedicine

Chitosan-Glutathione nanoparticles modify oxidative stress induced by doxorubicin in breast cancer cells

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