Anti-pre-S2 antibody response in subjects vaccinated against hepatitis B and in naturally immunized subjects

Lavanchy, Daniel; Fritzell, Bernard; Geudelin, B.; Peitrequin, R.; Frei, P.C.

doi:10.1016/0923-2516(91)90003-l

Cited by 2 publications

(1 citation statement)

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“…Results were calculated by means of a standard curve established with a reference serum and expressed quantitatively in IU/I. The specificity was controlled by an inhibition test using soluble pre-S2 polypeptide (27).…”

Section: Techniques Preliminary Screening For Hbsag and Anti-mentioning

confidence: 99%

Immunogenicity of a recombinant pre-S2-containing hepatitis B vaccine versus plasma-derived vaccine administered as a booster

Bucher

Francioli

Geudelin

et al. 1994

Eur. J. Clin. Microbiol. Infect. Dis.

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GenHevac B Pasteur is a recombinant hepatitis B vaccine derived from a mammalian cell line and containing HBs as well as pre-S2 antigens. Its immunogenicity was compared to that of the plasma-derived vaccine Hevac B Pasteur in a population primovaccinated 5.5 years earlier with four injections of the same plasma vaccine. The booster injection with either GenHevac or Hevac was administered to 295 subjects with residual anti-HBs titres below 500 IU/l (group 1: 0-9; group 2: 10-99; group 3: 100-499 IU/l). After four weeks, GenHevac had induced higher anti-HBs responses than Hevac in all groups, particularly among the low responders of group 1. Response to the vaccine occurred earlier with GenHevac. Mean anti-pre-S2 production was moderate in all groups for both vaccines (GenHevac: 60 IU/l; Hevac: 31 IU/l) and was not found in the 32 subjects who produced less than 100 IU/l anti-HBs. The results of the present study indicate that GenHevac is at least as immunogenic as Hevac.

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Section: Techniques Preliminary Screening For Hbsag and Anti-mentioning

confidence: 99%