Anti-platelet and anti-coagulant therapy in peripheral arterial disease prior to surgical intervention

Harky, Amer; Maskell, Perry; Burgess, Mika

doi:10.1177/1708538118818622

Cited by 9 publications

(4 citation statements)

References 60 publications

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“…3 Similar to age and diabetes mellitus (DM), hyperlipidemia is one of the known risk factors of atherosclerosis. 4 Increased triglyceride (TG) and decreased high density lipoprotein cholesterol (HDL-C) values increase atherosclerosis risk. With regard to this information, TG/HDL-C ratio is used as the atherogenic index.…”

Section: Introductionmentioning

confidence: 99%

Is it possible to predict the complexity of peripheral artery disease with atherogenic index?

2020

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Objectives Lower extremity peripheral artery disease develops mainly due to atherosclerosis and occurs as a result of the systemic atherosclerotic process. Increased triglyceride (TG) and decreased high density lipoprotein cholesterol (HDL-C) values increase atherosclerosis risk. With regard to this information, TG/HDL-C ratio is used as the atherogenic index. The aim of the present study was to evaluate the role of TG/HDL-C ratio to predict the complexity of disease in patients with peripheral artery disease. Methods Patients who were diagnosed with peripheral artery disease and admitted to our clinic between August 2013 and August 2019 were included in this study retrospectively. Patients were divided into two groups based on angiographic evaluations with TransAtlantic Inter-Society Consensus-II classification. Those with TASC A-B lesions were included in Group 1 and those with TASC C-D lesions constituted Group 2. Results The mean ages of Group 1 ( n = 314) and Group 2 ( n = 98) patients were 56.1 ± 9.3 and 58.4.1 ± 8.1 years, respectively. The frequency of male gender and coronary artery disease was significantly higher in Group 2 ( p = 0.043, p = 0.001, respectively). In Group 2, triglyceride and TG/HDL-C ratios were significantly high, while HDL-C was significantly low ( p = 0.022, p < 0.001, p = 0.010, respectively). The multivariate logistic regression analysis performed to evaluate the parameters in predicting the angiographic complexity of peripheral artery disease showed that coronary artery disease (OR: 1.009 CI 95%: 1.003–1.021 p = 0.016) and TG/HDL-C ratio (OR: 5.385 CI 95%: 2.553–9.357 p = 0.001) were independent predictors for complexity. ROC analysis revealed that the cut-off value of TG/HDL-C was 2.9 (AUC = 0.670, p < 0.001) with 75.5% sensitivity and 56.7% specificity. Conclusions It is possible to predict the angiographic complexity of peripheral artery disease with TG/HDL-C ratio, also known as atherogenic index, which is easily obtained by routine biochemical parameters.

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Section: Introductionmentioning

confidence: 99%

Is it possible to predict the complexity of peripheral artery disease with atherogenic index?

2020

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“…15 As peripheral artery disease is a complex condition, Harky et al shown that anticoagulant therapy is paramount to preventing disease. 16 Several observatories report that the global outbreak of coronavirus disease 2019 (COVID-19) is a hypercoagulable disorder. 17 A retrospective multicenter cohort study about COVID-19 shown that the potential risk factors of older age, high SOFA score, and d-dimer greater than 1mg/mL may have a poor prognosis at an early stage.…”

Section: Discussionmentioning

confidence: 99%

“…15 As peripheral artery disease is a complex condition, Harky et al shown that anticoagulant therapy is paramount to preventing disease. 16…”

Section: Discussionmentioning

confidence: 99%

The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics

Huang

Zhong

Liu

2021

Clin Appl Thromb Hemost

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Diabetes, regarded as a global health concerned disease, was focused by the World Health Organization (WHO). Patients with diabetes may have a hypercoagulable and hypo-fibrinolysis state. There is lots of research about cardiovascular effects on diabetes patients, but less about the coagulation system. This study is designed to investigate the relationship between coagulation indicators and 30-day mortality of critical diabetes patients. In this retrospective, single-center study, we included adult patients diagnosed with diabetes. Data, including demographic, complication, laboratory tests, scoring system, and anticoagulant treatment, were extracted from Medical Information Mart for Intensive Care (MIMIC-III). The receiver operating characteristic (ROC) curve and Kaplan-Meier curve were applied to predict the association of mortality and coagulation indicators. Cox hazard regression model and subgroup analysis were used to analyze the risk factors associated with 30-day mortality. A total of 4026 patients with diabetes mellitus were included in our study, of whom 3312 survived after admitted to the hospital and 714 died. Cox hazard regression showed anticoagulant therapy might decrease the risk of 30-day mortality after adjusted. In age <70 subgroup analysis, we found that patients with PTT <26.8 s or lightly increased PT may increase odds of 30-day hospital death (HR, 95%CI, 2.044 (1.376, 3.034), 1.562 (1.042, 2.343)). When age >70, lightly increased PTT may reduce the risk of mortality, but PT >16.3 s, a high level of hypo-coagulation state, increase risk of mortality (HR, 95%CI, 0.756 (0.574, 0.996), 1.756 (1.129, 2.729)). Critical diabetes patients may benefit from anticoagulant agents. The abnormal coagulant function is related to the risk of 30-day mortality.

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“…Ischemic heart disease is a leading cause of morbidity and mortality worldwide (1). Anti-thrombotic therapy and intervention are the main strategies to protect cardiomyocytes against hypoxia-induced damage (2).…”

Section: Introductionmentioning

confidence: 99%

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway

Zhou¹,

Mo²,

Huang³

et al. 2022

Ann Transl Med

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Background: This study investigated the potential effects of 3-iodothyronamine (T1AM) on myocardial ischemia reperfusion injury (MIRI) and the underlying molecular mechanisms.Methods: A total of 16 adult male Sprague-Dawley rats were randomly divided into 4 groups and administered the following: control (60% DMSO and 40% saline, pH 7.4), T1AM (25 mg/kg), T1AM (50 mg/kg), or T1AM (100 mg/kg). The rectal temperatures of the rats were measured at different time points. A further 30 adult male Sprague-Dawley rats were randomized and divided into the following 3 groups (n=10 in each group): sham operation, ischemia/reperfusion (I/R), and I/R + T1AM. In the I/R and I/R + T1AM groups, the left anterior descending (LAD) coronary artery of the rats were occluded for 0.5 hour to induce myocardial ischemia, followed by reperfusion for 3 hours in the I/R group. The electrocardiography (ECG), cardiac function, and 2,3,5-triphenyltetrazolium chloride (TTC) staining were examined in rats to evaluate the myocardial injury. The differences in the expression of apoptosis-related and Akt-FoxO1 signaling-related proteins were determined via Western blot.Results: This work verified that T1AM reduced the body temperature of rats in a dose-dependent manner.Additionally, T1AM improved cardiac function and decreased the infarction size caused by MIRI. T1AM reduced the expression of biochemical parameters and apoptosis of myocardial cells. In addition, after treatment with T1AM, the expression of Glut1, pFoxO1 and Akt were reduced, while the expression of FoxO1 and PPARα were increased significantly.Conclusions: Pretreatment of cardiomyocytes with T1AM inhibited apoptosis and protected against ischemia reperfusion injury via the Akt/FoxO1 signaling pathway.

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Anti-platelet and anti-coagulant therapy in peripheral arterial disease prior to surgical intervention

Cited by 9 publications

References 60 publications

Is it possible to predict the complexity of peripheral artery disease with atherogenic index?

Is it possible to predict the complexity of peripheral artery disease with atherogenic index?

The Association of Coagulation Indicators and Coagulant Agents With 30-Day Mortality of Critical Diabetics

3-iodothyronamine inhibits apoptosis induced by myocardial ischemia reperfusion via the Akt/FoxO1 signaling pathway

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