“…Our analysis showed that the frequency of responders to PvAMA-1 and PvDBP-RII was higher in the multiple-infected. This data suggests that multiple infections provide a boost to the production of specific antibodies confirming recent observations obtained in other studies in distinct endemic areas of Brazilian Amazon (Ceravolo et al 2005, Tran et al 2005). In the case of PvMSP1 19 , specific IgG responses developed faster after a single exposition to malaria infection, also confirming previous observations of distinct groups that PvMSP1 19 is highly immunogenic during natural human infections (Park et al 2001, Lim et al 2002, Rodrigues et al 2003, Morais et al 2005, Wickramarachchi et al 2007).…”