Anti‐Phospholipid Antibodies in Preeclampsia and Their Binding Ability for Placental Villous Lipid Fractions

Yamamoto, Tatsuo; Takahashi, Yuko; Geshi, Yumi; Sasamori, Yukifumi; Mori, H

doi:10.1111/j.1447-0756.1996.tb00979.x

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…In preeclampsia, many autoantibodies such as anti nuclear, anti phospholipid, anti endothelial antibody, anti angiotensin receptor agonistic antibody and others were reported 16,17 . Zhou et al 7 .…”

Section: Discussionmentioning

confidence: 99%

Effect on the Production of Soluble Endoglin from Human Choriocarcinoma Cells by Preeclampsia Sera

Aoki

Yamamoto

Chishima

et al. 2011

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Effect on the Production of Soluble Endoglin from Human Choriocarcinoma Cells by Preeclampsia Sera

Aoki

Yamamoto

Chishima

et al. 2011

American J Rep Immunol

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“…A procoagulant contribution from activated blood platelets may be less important, considering that a significantly lower number of PS-expressing, plateletderived microvesicles are found in pre-eclampsia, relative to that found during normal pregnancy [176]. In some but not all cases, patients with pre-eclampsia are positive for antibodies directed against lipid-bound b 2 -glycoprotein I [177][178][179]. Both conditions have been proposed to contribute to thrombosis in the intervillous spaces on the maternal side of the placenta, impeding placental perfusion.…”

Section: Pre-eclampsiamentioning

confidence: 94%

Surface exposure of phosphatidylserine in pathological cells

Zwaal

Comfurius

Bevers

2005

CMLS, Cell. Mol. Life Sci.

684

594

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The asymmetric phospholipid distribution in plasma membranes is normally maintained by energy-dependent lipid transporters that translocate different phospholipids from one monolayer to the other against their respective concentration gradients. When cells are activated, or enter apoptosis, lipid asymmetry can be perturbed by other lipid transporters (scramblases) that shuttle phospholipids non-specifically between the two monolayers. This exposes phosphatidylserine (PS) at the cells' outer surface. Since PS promotes blood coagulation, defective scramblase activity upon platelet stimulation causes a bleeding disorder (Scott syndrome). PS exposure also plays a pivotal role in the recognition and removal of apoptotic cells via a PS-recognizing receptor on phagocytic cells. Furthermore, expression of PS at the cell surface can occur in a wide variety of disorders. This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal.

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“…In other words, the relationship between hypertension, cerebral hemorrhage and infarction is complex. Furthermore, studies have suggested immune system involvement in pregnancy hypertension [38][39][40][41], but not in essential hypertension.…”

Section: Pih Susceptibility Genesmentioning

confidence: 99%

Comparison between Essential Hypertension and Pregnancy-induced Hypertension: a Genetic Perspective

Nakayama

Yamamoto

2009

Endocr J

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Abstract. Essential hypertension (EH) accounts for 80-90% of hypertension, and pregnancy-induced hypertension (PIH) is responsible for hypertension during pregnancy. Both considered multifactorial disorders. While both have many features in common, conditions and causes of these diseases have yet to be clarified. Since both diseases are associated with hypertension, the genetic backgrounds may contain common features. The present study reviewed similarities and differences between women with EH and PIH, with a particular focus on their genetic backgrounds.

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Anti‐Phospholipid Antibodies in Preeclampsia and Their Binding Ability for Placental Villous Lipid Fractions

Abstract: The results suggest that one cause of preeclampsia is the production of antiphospholipid antibodies that bind to placental villous membrane antigens.

Cited by 13 publications

References 20 publications

Effect on the Production of Soluble Endoglin from Human Choriocarcinoma Cells by Preeclampsia Sera

Effect on the Production of Soluble Endoglin from Human Choriocarcinoma Cells by Preeclampsia Sera

Surface exposure of phosphatidylserine in pathological cells

Comparison between Essential Hypertension and Pregnancy-induced Hypertension: a Genetic Perspective

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