Anti-pharmacophore Identification and Structure-Activity Relationships for the Inhibition of Cellular Protein and DNA Syntheses by a Series of Thiosemicarbazones and Thiosemicarbazides

Abstract

Background: Structure-activity relationship (SAR) of a series of thiosemicarbazone and thiosemicarbazide derivatives (57 compounds) that are potent inhibitors of herpes simplex virus (HSV) has been investigated for their inhibitory effects on cellular protein and DNA syntheses by electron-conformational method. SAR and QSAR studies were already carried out for these compounds in terms of their anti-HSV activity and dermal toxicity. The effect of a compound on cellular growth needs also to be known before its usage in chemotherapy. Therefore, this is a complementary study in designing new nontoxic antiviral drugs with reduced side effects on protein and DNA syntheses.