Anti-parasitic effect on Toxoplasma gondii induced by a spider peptide lycosin-I

Tang, Yaqin; Hou, Shengjie; Li, Xianyao; Wu, Mengqi; Ma, Binbin; Wang, Zheng; Jiang, Jialiang; Deng, Mei; Duan, Zhigui; Xing, Tao; Liu, Yuan; Wang, Wenhua; Han, Xiaoqing; Jiang, Liping

doi:10.1016/j.exppara.2019.01.009

Cited by 24 publications

(17 citation statements)

References 70 publications

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“…As a member of the phylum apicomplexa, Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan capable of infecting a world-wide range of hosts, including most warm-blooded animals like humans and cats (Saad et al, 2018;Tang et al, 2019). It is estimated that about one-third of the world's human population has been infected with T. gondii.…”

Section: Introductionmentioning

confidence: 99%

A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation

Yan

Jiang

et al. 2020

Front. Microbiol.

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Section: Introductionmentioning

confidence: 99%

A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation

Yan

Jiang

et al. 2020

Front. Microbiol.

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“…Similarly, Oh-defensin from the venom of Ornithoctonus hainana displayed antimicrobial activities against Gram-positive and Gram-negative bacteria as well as against fungi [26]. Peptides from the venom of spiders are also able to display antiparasitic effects, Lycosin-I derived from the venom of the spider Lycosa singoriensis had antiparasitic effects against Taxoplasma gondii both in vitro and in vivo [27]. This peptide exhibits rapid and broad-spectrum bactericidal activity by interacting directly with the bacterial cell membrane [28].…”

Section: Antimicrobial Agents From Spidersmentioning

confidence: 99%

Antimicrobials from Venomous Animals: An Overview

et al. 2020

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The inappropriate or excessive use of antimicrobial agents caused an emerging public health problem due to the resulting resistance developed by microbes. Therefore, there is an urgent need to develop effective antimicrobial strategies relying on natural agents with different mechanisms of action. Nature has been known to offer many bioactive compounds, in the form of animal venoms, algae, and plant extracts that were used for decades in traditional medicine. Animal venoms and secretions have been deeply studied for their wealth in pharmaceutically promising molecules. As such, they were reported to exhibit many biological activities of interest, such as antibacterial, antiviral, anticancer, and anti-inflammatory activities. In this review, we summarize recent findings on the antimicrobial activities of crude animal venoms/secretions, and describe the peptides that are responsible of these activities.

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“…The interaction between lycosin-I and the negatively charged intruder cell mediates the disruption of the membrane, exposing the compound to the intracellular environment, where it can concomitantly affect internal structures and lead to organelle damage, loss of shape, vacuolization, and breakdown [58,59]. Additionally, this molecule was shown to inhibit intracellular proliferation of tachyzoites, with inhibition rates higher than those observed in treatments with sulfadiazine [109]. Apart from the direct mechanism of inhibition, lycosin-I was also shown to activate an immune response through an increase in the production of interleukins IL-6 and IL-8 cytokines [109].…”

Section: Immunomodulatory Agents Antimicrobial Peptidesmentioning

confidence: 99%

“…Additionally, this molecule was shown to inhibit intracellular proliferation of tachyzoites, with inhibition rates higher than those observed in treatments with sulfadiazine [109]. Apart from the direct mechanism of inhibition, lycosin-I was also shown to activate an immune response through an increase in the production of interleukins IL-6 and IL-8 cytokines [109]. Scheme 1 depicts the inhibition pathways mediated by lycosin-I.…”

Section: Immunomodulatory Agents Antimicrobial Peptidesmentioning

confidence: 99%

Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses

et al. 2020

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Toxoplasmosis is an infectious disease with paramount impact worldwide, affecting many vulnerable populations and representing a significant matter of concern. Current therapies used against toxoplasmosis are based essentially on old chemotypes, which fail in providing a definitive cure for the disease, placing the most sensitive populations at risk for irreversible damage in vital organs, culminating in death in the most serious cases. Antimalarial drugs have been shown to possess key features for drug repurposing, finding application in the treatment of other parasite-borne illnesses, including toxoplasmosis. Antimalarials provide the most effective therapeutic solutions against toxoplasmosis and make up for the majority of currently available antitoxoplasmic drugs. Additionally, other antiplasmodial drugs have been scrutinized and many promising candidates have emanated in recent developments. Available data demonstrate that it is worthwhile to explore the activity of classical and most recent antimalarial chemotypes, such as quinolines, endoperoxides, pyrazolo[1,5-a]pyrimidines, and nature-derived peptide-based parasiticidal agents, in the context of toxoplasmosis chemotherapy, in the quest for encountering more effective and safer tools for toxoplasmosis control or eradication.

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Anti-parasitic effect on Toxoplasma gondii induced by a spider peptide lycosin-I

Cited by 24 publications

References 70 publications

A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation

A Novel wx2 Gene of Toxoplasma gondii Inhibits the Parasitic Invasion and Proliferation in vitro and Attenuates Virulence in vivo via Immune Response Modulation

Antimicrobials from Venomous Animals: An Overview

Antimalarial Agents as Therapeutic Tools Against Toxoplasmosis—A Short Bridge between Two Distant Illnesses

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