Anti-Oxidative and Anti-Obesity Effects of Amomum Cardamomum L. Extract

Park, Jung Ae; Jin, Kyong-Suk; Lee, Jun-Young; Kwon, Hyun Ju; Kim, Byung Woo

doi:10.4014/kjmb.1403.03001

Cited by 4 publications

(1 citation statement)

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“…The plant seeds are widely used as a spice in many countries and traditionally as a therapeutic for relief of dyspepsia, hiccupping, vomiting, and alcohol detoxification [ 23 ]. The previous studies have reported that seed of A. cardamomum and its active components had antioxidant and anti-inflammatory activities [ 24 , 25 ]. Important essential oils constituents including terpenes have been reported in this plant [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats

Lim

Kim

Park

et al. 2016

BMC Complement Altern Med

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BackgroundMedicinal herb-derived drug development has become important in the relief of liver pathology. Amomun cardamomum is traditionally used therapeutically in Korea to treat various human ailments including dyspepsia, hiccupping, and vomiting. We investigated to assess the protective effect of A. cardamomum on carbon tetrachloride (CCl4)-induced liver damage through antioxidant activity in hepatic tissues of Sprague–Dawley rats.MethodsAntioxidant properties of different fractions from A. cardamomum from ethanol extracts were evaluated by an in vitro free radical scavenging systems. The protective effect of the ethyl acetate fraction from A. cardamomum (EAAC) against CCl4-induced cytotoxicity was determined by a cell viability assay using HepG2 hepatocarcinoma cells. In vivo study, the influence of EAAC concentrations of 100 and 200 mg/kg following CCl4-induced hepatic injury was assessed. Serum levels of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP) were determined, as was lipid peroxidation (malondialdehyde, MDA). Effect of EAAC on liver detoxification enzymes including superoxide dismutase (SOD), total glutathione (GSH), and glutathione S-transferase (GST) activity was measured in rat liver homogenates. Liver cytochrome P450 (CYP2E1) expression level was determined by quantification of mRNA.ResultsPhytochemical analysis of A. cardamomum indicated that EAAC was enriched in total polyphenol and total flavonoid. Most of the tannins were confined to the hexane fraction. Hepatoprotective properties of EAAC were evident, with significantly reduced serum levels of GOT, GPT, and ALP compared with the control group. Improved hepatic antioxidant status was evident by increased SOD, GSH, and GST enzymes in rat liver tissue. Liver lipid peroxidation induced by CCl4 was apparent by increased intracellular MDA level. EAAC suppressed lipid peroxidation as evidenced by the significant decrease in MDA production. Expression of CYP2E1 was also significantly decreased at the higher concentration of EAAC, indicating the hepatoprotective efficacy of EAAC on acute liver damage.ConclusionThese results indicated that EAAC has a significant hepatoprotective activity on CCl4-induced acute hepatic injury in rats, which might be derived from its antioxidant properties and CYP2E1 downregulation.

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Section: Introductionmentioning

confidence: 99%

Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats

Lim

Kim

Park

et al. 2016

BMC Complement Altern Med

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The ethanolic extract of Korean Curcuma longa rhizome inhibits adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obese mice via activating AMPK signaling pathway

Lee,

Kim,

Jin

et al. 2023

Journal of Functional Foods

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Biological activity of Brassica oleracea var. capitata fermented with Lactobacillus plantarum

Lee¹,

Park²,

Choi³

et al. 2022

Korean J. Food Preserv.

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White cabbage (Brassica oleracea var. capitata) reportedly exerts antioxidant, anti-inflammatory, and anti-gastric effects. We aimed to evaluate the biological activity of B. oleracea fermented with Lactobacillus plantarum (FBO). The plant material was fermented for 7 d. The antioxidative potentials of FBO (DPPH radical-scavenging activity, and total phenol and total flavonoid contents) and ability of FBO to inhibit digestive enzymes (α-amylase and lipase) were tested. Anti-inflammatory and anti-allergic effects were also determined by measuring the release of NO, inflammatory cytokines (IL-1β, TNF-α and IL-4), β-hexosaminidase and histamine. FBO contained 15.84±0.25 mg GAE/g phenols and 1.19±0.09 mg NA/g flavonoids. FBO showed DPPH radical-scavenging activity, and inhibited α-amylase and lipase. It also inhibited of NO, PGE2 and inflammatory cytokine production by LPS-stimulated RAW 264.7 macrophages. Finally, FBO inhibited degranulation and inflammatory cytokine production in antigen-stimulated RBL-2H3 mast cells, in a dose-dependent manner. Collectively, these observations indicate that white cabbage fermented with L. plantarum can be used as a functional material and edible resource in industrial setting.

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Anti-Oxidative and Anti-Obesity Effects of Amomum Cardamomum L. Extract

Cited by 4 publications

References 0 publications

Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats

Amomum cardamomum L. ethyl acetate fraction protects against carbon tetrachloride-induced liver injury via an antioxidant mechanism in rats

The ethanolic extract of Korean Curcuma longa rhizome inhibits adipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obese mice via activating AMPK signaling pathway

Biological activity of Brassica oleracea var. capitata fermented with Lactobacillus plantarum

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