Anti-oxidation properties of leaves, skin, pulp, and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells

Hadadi, Shrefa A.; Li, Haiwen; Rafie, Reza; Kaseloo, Paul; Witiak, Sarah Melissa; Siddiqui, Rafat A.

doi:10.20517/2394-4722.2018.22

Cited by 7 publications

(2 citation statements)

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“…Similarly, Bhakta and Ganjewala (2009) [31] reported that the dried, young leaves of Lantana camara L. had higher total phenolic compounds than dried mature and old leaves. According to Haddadi et al (2018) [32], the leaves of green papaya contained higher total phenolic compounds than skin and pulp. Rebaya et al (2016) [33] also reported that higher contents of total phenolic compounds were evident in rockrose ( Cistus salviifolius ) leaves compared to its flowers.…”

Section: Resultsmentioning

confidence: 99%

Determination of Phenolic Compounds, Procyanidins, and Antioxidant Activity in Processed Coffea arabica L. Leaves

Ngamsuk

Huang

Hsu

2019

Foods

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The effects of dry processing and maturity on antioxidant activity, total phenolic content, total procyanidins, and identity of phenolic compounds in coffee leaves were evaluated. Fresh coffee leaves were tray-dried at 40 °C for 8 h before total phenolic content, total procyanidins, and antioxidant activity were analyzed. The drying process significantly (p < 0.05) improved the release of total phenolic content and total procyanidins compared with the fresh leaves. The results showed that the young leaves exposed to drying processes had the highest total phenolic content, total procyanidins, and DPPH radical scavenging activity. Therefore, the effect of different drying temperatures (30, 40, and 50 °C) in the young leaves were further analyzed. The results indicated that DPPH radical scavenging activity, total phenolic content, and total procyanidins were increasingly generated when exposed to an increase in drying temperatures, whereby the highest bioactivity was evident at 50 °C. The DPPH radical scavenging activity of the coffee leaf teas was significantly correlated with total phenolic content and total procyanidins. Identification of Coffea arabica L. bioactive compounds by LC-MS showed the presence of catechin or epicatechin, mangiferin or isomangiferin, procyanidin B, caffeoylquinic acids (CQA), caffeine, quercetin-3-O-glucoside, procyanidin C, rutin, and 3,4-diCQA. Coffea arabica L. leaf tea was confirmed to be a potential functional food rich in phenolic compounds with strong antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Determination of Phenolic Compounds, Procyanidins, and Antioxidant Activity in Processed Coffea arabica L. Leaves

Ngamsuk

Huang

Hsu

2019

Foods

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“…Of all the papaya fractions, ethanolic extracts of papaya have greater anti-oxidation activity compared to aqueous extracts. This is attributed to the solubility of polyphenol's chemical structure (Hadadi et al, 2018). Similarly, leaf juice extracts have demonstrated stronger cytotoxic effect than brewed decoction as the bioactive compounds in papaya being temperature sensitive and can be heat-inactivated.…”

Section: Resultsmentioning

confidence: 99%

Carica Papaya Leaf Extracts: A Novel Herbal Drug in Cancer Treatment

Rajashri

Neralla

George

et al. 2020

ijrps

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With the continued increase in Cancer incidence and deaths, traditional clinical therapies like surgery, radiation, chemotherapy, immunosuppression alone are not enough to counteract cancer due to their cost and its associated side effects, thus emphasizing the need for a novel intervention plan. Hippocrates's (5 th century BCE) quote "Let food be thy medicine, and let thy medicine be thy food" is well popular all over the world and thus food was chosen to enhance health and emotional wellbeing that caused the change in trend in the market for natural products that help in combating cancer. Cancer statistics showed that the consumption of diets rich in fresh fruits and vegetables is inversely associated with cancer incidence, which leads to study plant-based dietary antioxidants and its therapeutic role in cancer, which was underestimated in the past. This review is about the potential bene its of leaf extracts of Carica papaya in treating various cancers of the body; and its implication in the management of oral cancers.

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Therapeutic application of Carica papaya leaf extract in the management of human diseases

et al. 2020

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Anti-oxidation properties of leaves, skin, pulp, and seeds extracts from green papaya and their anti-cancer activities in breast cancer cells

Cited by 7 publications

References 0 publications

Determination of Phenolic Compounds, Procyanidins, and Antioxidant Activity in Processed Coffea arabica L. Leaves

Determination of Phenolic Compounds, Procyanidins, and Antioxidant Activity in Processed Coffea arabica L. Leaves

Carica Papaya Leaf Extracts: A Novel Herbal Drug in Cancer Treatment

Therapeutic application of Carica papaya leaf extract in the management of human diseases

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