Anti-Oxidation and Anti-Inflammatory Potency Evaluation of Ferulic Acid Derivatives Obtained through Virtual Screening

Shi, Yong; Chen, Xuelian; Qiang, Shaojia; Su, Jie; Li, Jiazhong

doi:10.3390/ijms222111305

Cited by 21 publications

(10 citation statements)

References 31 publications

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“…This finding could be attributed to the high abundance and diversity of phenolic compounds in the BP fraction ( Table 3 ). Ferulic acid and its derivatives, a major phenolic compound in BP extracts of WB, prevented inflammation and oxidative stress in LPS-stimulated RAW264.7 cells by suppression of intracellular ROS and inflammatory mediators, including iNOS, COX-2, TNF-alpha and IL-6 [ 78 ]. Besides, in a recent in vivo study of El-gogary et al [ 79 ], the administration of FA in lipid nanocapsules reduced significantly the TNF-α and NF-kB levels in colorectal cancer-induced rats.…”

Section: Resultsmentioning

confidence: 99%

Impact of Protein Content on the Antioxidants, Anti-Inflammatory Properties and Glycemic Index of Wheat and Wheat Bran

Jiménez-Pulido

Rico

Pérez‐Jiménez

et al. 2022

Foods

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Conventional wheat milling generates important volumes of wheat bran (WB), which is a concentrated source of polyphenols and insoluble fiber. In terms of health benefits and based on epidemiological and experimental evidence, these compounds contribute to reducing the risk of certain chronic pathologies. Protein concentration is the main quality factor conditioning wheat use in the agroindustry. When turning waste into feasible resources, it is essential to evaluate the variability of the raw material. The aim of this study was the evaluation of the impact of protein content in the valorization of WB based on its antioxidants, anti-inflammatory properties and glycemic index (GI). A significantly (p ≤ 0.05) lower content of phenolic compounds was found in the whole grain (WG) fractions, both free (FP) and bound (BP), as compared to the WB phenolic fractions, differences that ranged from 4- to 6-fold (538 to 561 mg GAE 100 g−1 in WG vs. 1027 to 1236 in WB mg GAE 100 g−1 in FP and 2245 to 2378 vs. 6344 to 7232 mg GAE 100 g−1 in BP). A significant (p ≤ 0.05) effect of the protein content on the resulting phenolic content and antioxidant capacity was observed, especially in WG, but also in WB, although in the latter a significant (p ≤ 0.05) negative correlation was observed, and increasing the protein content resulted in decreasing total phenolic content, antioxidants, and ferric-reducing capacities, probably due to their different types of proteins. The highest protein content in WB produced a significant (p ≤ 0.05) reduction in GI value, probably due to the role of protein structure in protecting starch from gelatinization, along with phytic acid, which may bind to proteins closely associated to starch and chelate calcium ions, required for α-amylase activity. A significant (p ≤ 0.05) effect of the protein content on the GI was also found, which may be explained by the structural effect of the proteins associated with starch, reducing the GI (21.64). The results obtained show the importance of segregation of WB in valorization strategies in order to increase the efficiency of the processes.

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Section: Resultsmentioning

confidence: 99%

Impact of Protein Content on the Antioxidants, Anti-Inflammatory Properties and Glycemic Index of Wheat and Wheat Bran

Jiménez-Pulido

Rico

Pérez‐Jiménez

et al. 2022

Foods

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“…Neuroinflammation is a driver for traumatic exacerbation via cascade inflammatory infiltration and cellular lesion (Delage et al, 2021 ). Increasing reports have proven that the antioxidation and antiinflammatory properties of ferulic acid is well recognized in preclinical studies (Shi et al, 2021 ). Current findings demonstrated that an antineuroinflammation action may be one of the pharmacological mechanisms of ferulic acid in treating TBI.…”

Section: Discussionmentioning

confidence: 99%

Preclinical findings reveal the pharmacological targets of ferulic acid in the treatment of traumatic brain injury

Dong¹,

Yang²,

Liao³

et al. 2022

Food Science & Nutrition

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Traumatic brain injury (TBI) is characterized by cellular damage and inflammation in lesioned brain tissue. Ferulic acid has been shown to have a melioration effect on neurological functions. However, the active pharmacological effects and the underlying mechanisms of ferulic acid against TBI remain unclear. On the basis of network pharmacology and molecular docking methodology, this study aimed to investigate the beneficial effects of ferulic acid in treating TBI, and characterized the detailed biotargets and mechanisms of these actions. The identified core targets were validated via in silico simulation. We identified 91 overlapping targets associated with ferulic acid and TBI. In‐silico simulation analysis validated the putative core targets of tumor protein p53, mitogen‐activated protein kinase (MAPK) 1, and estrogen receptor 1. The Gene Ontology‐enriched annotations and findings were largely associated with cell proliferation, apoptosis, and inflammation in nerve cells. Additional Kyoto Encyclopedia of Genes and Genomes enrichment analysis unmasked the pharmacological pathways of ferulic acid in treating TBI, including the MAPK signaling pathway and hypoxia‐inducible factor‐1 signaling pathway. Bioinformatic analyses and findings provide a new preclinical strategy for revealing the core targets and network pathways of ferulic acid in treating TBI. Moreover, some bioinformatic findings were computationally validated in silico for exhibiting the neuroprotective action of ferulic acid against TBI.

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“…Phenolic acids have many health benefits. These include anti-inflammatory and antioxidative actions ( 81 , 82 ), antidiabetic ( 83 ), and hepatoprotective ( 84 ), and antineoplastic ( 85 , 86 ). Caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) is reported cytotoxic and anti-proliferative actions on RPMI 8226, H929, U266 and ARH77 cell lines, and also synergises with bortezomib in growth inhibition and reduction of NF-kB binding activity and IL6 levels ( 87 ).…”

Section: Flavonoidsmentioning

confidence: 99%

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

Izuegbuna

2022

Front. Nutr.

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Polyphenols are one of the largest plant-derived natural product and they play an important role in plants’ defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to possess antineoplastic properties which include cell cycle arrest, and apoptosis via multiple mechanisms. They also have immunomodulatory activities where they enhance T cell activation and suppress regulatory T cells. They carry out these actions through such pathways as PI3K/Akt/mTOR and the kynurenine. They can also reverse cancer resistance to chemotherapy agents. In this review, i look at some of the molecular mechanism of action of polyphenols and their potential roles as therapeutic agents in hematological malignancies. Here i discuss their anti-proliferative and anti-neoplastic activities especially their abilities modulate signaling pathways as well as immune response in hematological malignancies. I also looked at clinical studies done mainly in the last 10–15 years on various polyphenol combination and how they enhance synergism. I recommend that further preclinical and clinical studies be carried out to ensure safety and efficacy before polyphenol therapies be officially moved to the clinics.

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Anti-Oxidation and Anti-Inflammatory Potency Evaluation of Ferulic Acid Derivatives Obtained through Virtual Screening

Cited by 21 publications

References 31 publications

Impact of Protein Content on the Antioxidants, Anti-Inflammatory Properties and Glycemic Index of Wheat and Wheat Bran

Impact of Protein Content on the Antioxidants, Anti-Inflammatory Properties and Glycemic Index of Wheat and Wheat Bran

Preclinical findings reveal the pharmacological targets of ferulic acid in the treatment of traumatic brain injury

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

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