Anti‐oxidant Properties of C<sub>60</sub>Fullerenes<i>in vitro</i>

Prylutska, Svitlana; Grynyuk, І. І.; Matyshevska, Olga; Prylutskyy, Yu. І.; Ritter, Uwe; Scharff, P.

doi:10.1080/15363830802317148

Cited by 70 publications

(31 citation statements)

References 11 publications

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“…In this context, bioactive soluble carbon nanostructures, such as the pristine C 60 fullerenes, may be considered potential antioxidants [13]. C 60 fullerene easily bonds with up to six electrons, can serve as a powerful scavenger of ROS [13–15], and is superior to the majority of natural antioxidants, including vitamins C and E and carotenoids, in regard to its antioxidant capacity. As a result, it prevents oxidative stress dissemination in thymocytes [16] and shows a protective effect following the ischemia–reperfusion injury of skeletal muscle [17].…”

Section: Introductionmentioning

confidence: 99%

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

et al. 2017

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BackgroundBioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely used to decrease the muscle fatigue effects. The aim of the study is to define action of the pristine C60 fullerene aqueous colloid solution (C60FAS), on the post-fatigue recovering of m. triceps surae in anaesthetized rats.ResultsDuring fatigue development, we observed decrease in the muscle effort level before C60FAS administration. After the application of C60FAS, a slower effort decrease, followed by the prolonged retention of a certain level, was recorded. An analysis of the metabolic process changes accompanying muscle fatigue showed an increase in the oxidative stress markers H 2 O 2 (hydrogen peroxide) and TBARS (thiobarbituric acid reactive substances) in relation to the intact muscles. After C60FAS administration, the TBARS content and H 2 O 2 level were decreased. The endogenous antioxidant system demonstrated a similar effect because the GSH (reduced glutathione) in the muscles and the CAT (catalase) enzyme activity were increased during fatigue.ConclusionsC60FAS leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that C60FAS affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance.

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Section: Introductionmentioning

confidence: 99%

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

et al. 2017

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“…It has been shown previously that C6fl fullerene is able to penetrate through the cell membrane (Foley et al 2002;Prylutska et al 2012;Qiao et al 2007) and exhib its antioxidant properties (Prylutska et al 2008). Being non-toxic, at least at low concentrations (Andrievsky et al 2005;Aschberger et al 2010;Kolosnjaj et al 2007;Prylut ska et al 2007a), pristine C6fl fullerenes are able to suppress the growth of malignant tumors (Prylutska et al 2011a, b).…”

Section: Introductionmentioning

confidence: 99%

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

et al. 2014

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C60 fullerenes are spherical molecules com posed purely of carbon atoms. They inspire a particularly strong scientific interest because of their specific physico chemical properties and potential medical and nanotech nological applications. In this work we are focusing on studying the influence of the pristine C60 fullerene on bio logical activity of some aromatic drug molecules in human buccal epithelial cells. Assessment of the heterochromatin structure in the cell nucleus as well as the barrier function of the cell membrane was performed. The methods of cell microelectrophoresis and atomic force microscopy were also applied. A concentration-dependent restoration of the functional activity of the cellular nucleus after exposure to DNA-binding drugs (doxorubicin, proflavine and ethidium bromide) has been observed in human buccal epithelial cells upon addition of C60 fullerene at a concentration of -1СГ5 M. The results were shown to follow the framework of interceptor/protector action theory, assuming that noncovalent complexation between C60 fullerene and the drugs (i.e., hetero-association) is the major process responsible for the observed biological effects. An independent con firmation of this hypothesis was obtained via investigation of the cellular response of buccal epithelium to the coad ministration of the aromatic drugs and caffeine, and it is based on the well-established role of hetero-association in drug-caffeine systems. The results indicate that C60 fuller ene may reverse the effects caused by the aromatic drugs, thereby pointing out the potential possibility of the use of aromatic drugs in combination with C60 fullerene for regu lation of their medico-biological action.

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“…D ue to its nanom eter size, the pristine C60 fullerenes are able to interact w ith biom ole cules (3,4) an d penetrate th ro u g h the cell m em brane (5,6). They exhibit antioxidant properties (7) and, being non-toxic (at low concentration at least) (8)(9)(10)(11)(12)(13), exert specific health effects (e.g., suppress the grow th o f m alignant tum ors (14,15)). A lthough these molecules have extrem ely low w ater solubility (16), they form stable colloid solutions containing individual C60 fullerenes as well as C60 fullerene aggregates (clusters) in w ater (17,18), w hen subjected to extended m ix ing, sonication, or solvent exchange (19,20).…”

Section: Introductionmentioning

confidence: 99%

Structural Features of Highly Stable Reproducible C₆₀Fullerene Aqueous Colloid Solution Probed by Various Techniques

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Prylutskyy

Evstigneev

et al. 2014

Fullerenes, Nanotubes and Carbon Nanostructures

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Anti‐oxidant Properties of C₆₀Fullerenesin vitro

Cited by 70 publications

References 11 publications

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Structural Features of Highly Stable Reproducible C₆₀Fullerene Aqueous Colloid Solution Probed by Various Techniques

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Anti‐oxidant Properties of C60Fullerenesin vitro

Cited by 70 publications

References 11 publications

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Structural Features of Highly Stable Reproducible C60Fullerene Aqueous Colloid Solution Probed by Various Techniques

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Product

Resources

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Anti‐oxidant Properties of C₆₀Fullerenesin vitro

Structural Features of Highly Stable Reproducible C₆₀Fullerene Aqueous Colloid Solution Probed by Various Techniques