Anti oxidant potential of Metformin and Pioglitazone in Type 2 Diabetes Mellitus: Beyond their anti glycemic effect

Singh, Royana; Gupta, B. B. P.; Tripathi, Kamlakar; Singh, Shivendra Kumar

doi:10.1016/j.dsx.2015.08.016

Cited by 19 publications

(21 citation statements)

References 13 publications

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“…After the treatment with HEPa/EtOAc, the Cu/Zn-SOD expression levels in liver and adipose tissue are increased in comparison with untreated obese mice, and also being then similar to that seen in the group treated with pioglitazone. In the same direction, other tools used in the prevention and combating of IR, such as exercise and metformin, also show the increase in SOD expression as one of the mechanisms of action [37][38][39]. Therefore, it was confirmed that HEPa/EtOAc treatment presents in the same line of action of the most important therapeutic tools in the fight against IR.…”

Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 50%

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

et al. 2016

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Parkinsonia aculeata L. (Caesalpiniaceae) is a traditional ethnomedicine and has been used for the empiric treatment of hyperglycemia, without scientific background. Mechanistic analyses at molecular level from the antioxidant mechanism observed by P. aculeata are required. Herein the effects of the treatment by hydroethanolic extract partitioned with ethyl acetate of P. aculeata aerial parts (HEPa/EtOAc) in mice fed a high-fat diet that share many obesity phenotypes with humans were evaluated. The animals were treated orally with HEPa/EtOAc (125 and 250 mg/kg/day) and pioglitazone (5 mg/kg/day), for 16 days. After the treatment, HEPa/EtOAc reduced fasting serum glucose and insulin levels, as well as homeostasis model assessment for insulin resistance. In addition, an improvement in glucose intolerance was also observed. Indeed, a reduction in the circulating levels of TNF-α and IL-6 was also observed. Furthermore, at molecular level, it was demonstrated that the HEPa/EtOAc treatment was able to improve these physiological parameters, through the activation of peroxisome proliferator-activated receptor γ (PPARγ) per si, as well as the enhancement of antioxidant mechanism by an increase in PPARγ/Cu(2+), Zn(2+)-superoxide dismutase (CuZn-SOD) axis expression in liver and adipose tissue. In sum, P. aculeata is effective to improve insulin resistance in a mouse model of obesity and this effect seems to involve the antioxidant and anti-inflammatory mechanisms through the increase in PPARγ/CuZn-SOD axis expression.

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Section: Data Presented By the World Health Organization (Who)mentioning

confidence: 50%

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

et al. 2016

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“…2) (Singh et al 2015). Pioglitazone was recently shown to reduce ER stress in Wfs1-deficient mice (Yamada et al 2006), a genetic model for ER stress-mediated β-cell loss and diabetes, thus almost preventing the onset of diabetes in those mice (Akiyama et al 2009).…”

Section: Existing Treatments Of T2d That Reduce Er Stressmentioning

confidence: 99%

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

Meyerovich

Ortis

Allagnat

et al. 2016

Journal of Molecular Endocrinology

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Insulin-secreting pancreatic β-cells are extremely dependent on their endoplasmic reticulum (ER) to cope with the oscillatory requirement of secreted insulin to maintain normoglycemia. Insulin translation and folding rely greatly on the unfolded protein response (UPR), an array of three main signaling pathways designed to maintain ER homeostasis and limit ER stress. However, prolonged or excessive UPR activation triggers alternative molecular pathways that can lead to β-cell dysfunction and apoptosis. An increasing number of studies suggest a role of these pro-apoptotic UPR pathways in the downfall of β-cells observed in diabetic patients. Particularly, the past few years highlighted a cross talk between the UPR and inflammation in the context of both type 1 (T1D) and type 2 diabetes (T2D). In this article, we describe the recent advances in research regarding the interplay between ER stress, the UPR, and inflammation in the context of β-cell apoptosis leading to diabetes.

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“…This is the first time a comparative assessment on TBARS concentration in different organs of experimental animal model is been carried out. Decrease in TBARS concentrations after pioglitazone treatment has been reported in humans 28,29 . Pioglitazone-treated non-alcoholic steatohepatitis (NASH) rats has been reported to show significant reduction in malondialdehyde levels when compared with that of NASH induced control group 30 .…”

Section: Discussionmentioning

confidence: 85%

Evaluation of Biochemical Toxicity and Antioxidant Properties of Pioglitazone on Albino Wistar Rats

Ogunlana¹,

Ogunlana²,

Ugochukwu³

et al. 2016

J. of Medical Sciences

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Pioglitazone is one of the thiazolidinedione anti-diabetic drugs which have been used for the treatment of non-insulin dependent diabetes mellitus. This study aims at investigating the biochemical effects and safety of pioglitazone (PIO) at various concentrations in female Wistar rats. A total of 28 rats were randomly divided into four groups of seven animals each. Groups 1-4 were given 0.5 mL kgG 1 b.wt., dayG 1 of distilled water as normal control; 15, 30 and 45 mg kgG 1 b.wt., dayG 1 of PIO, respectively as treatment groups 2, 3 and 4, respectively for 28 days. Using standard biochemical kits and reported chemical procedures, plasma biochemical parameter and organ lipid peroxidation effects were determined in all the groups. There was significant increase (p<0.05) in plasma total protein concentration of group 3 and 4 in comparison with control. There was also significant (p<0.05) reduction in total and LDL cholesterols in PIO-treated groups and concentration of TBARS was reduced in the liver and heart of PIO-treated groups in comparison with normal control. There was no significant alteration in the concentrations and activities of liver and kidney function markers of PIO treated groups in comparison with normal control groups. Pioglitazone at highest concentration of 45 mg kgG 1 b.wt., for the duration of 28 days did not elicit any measurable biochemical toxicity on non-diabetic rat model.

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Anti oxidant potential of Metformin and Pioglitazone in Type 2 Diabetes Mellitus: Beyond their anti glycemic effect

Cited by 19 publications

References 13 publications

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

Treatment with Parkinsonia aculeata combats insulin resistance-induced oxidative stress through the increase in PPARγ/CuZn-SOD axis expression in diet-induced obesity mice

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

Evaluation of Biochemical Toxicity and Antioxidant Properties of Pioglitazone on Albino Wistar Rats

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