Anti-oxidant modulation in response to gamma radiation induced oxidative stress in developing seedlings of Psoralea corylifolia L.

Jan, Sumira; Parween, Talat; Siddiqi, Tariq Omar; Mahmooduzzafar,

doi:10.1016/j.jenvrad.2012.05.019

Cited by 56 publications

(19 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These seeds have been widely studied for their antitumor, antioxidant, antimicrobial, and anti-inflammatory effects [12, 15, 19, 23]. In our previous study, PCS extract also showed antisenescence effects in human dermal fibroblasts [24].…”

Section: Discussionmentioning

confidence: 99%

Psoralea corylifoliaL. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

Seo

Lee

Lee³

et al. 2014

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus. Oxidative stress is one of the major causes of beta-cell death. In this study, we investigated the effects of Psoralea corylifolia L. seed (PCS) extract on beta-cell death. Oral administration of PCS extract resulted in a significant improvement of hyperglycemia in streptozotocin-induced diabetic mice. PCS extract treatment improved glucose tolerance and increased serum insulin levels. To study the mechanisms involved, we investigated the effects of PCS extract on H2O2-induced apoptosis in INS-1 cells. Treatment with PCS extract inhibited cell death. PCS extract treatment decreased reactive oxygen species level and activated antioxidative enzymes. Among the major components of PCS extract, psoralen and isopsoralen (coumarins), but not bakuchiol, showed preventive effects against H2O2-induced beta-cell death. These findings indicate that PCS extract may be a potential pharmacological agent to protect against pancreatic beta-cell damage caused by oxidative stress associated with diabetes.

show abstract

Section: Discussionmentioning

confidence: 99%

Psoralea corylifoliaL. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

Seo

Lee

Lee³

et al. 2014

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Therefore, modulation of these age-associated mitochondrial changes may slow the aging process and prevent or delay age-related diseases. PCS has been used traditionally as a medicine in Asia and are known to have antioxidant activity [21–23]. In particular, a component of PCS has liver detoxifying and hepatoprotective effects [16, 17, 24].…”

Section: Discussionmentioning

confidence: 99%

Protective Role ofPsoralea corylifoliaL. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging

Seo

Kim

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The accumulation of oxidative damage and mitochondrial dysfunction is an important factor that contributes to aging. The Psoralea corylifolia seeds (PCS), commonly known as “Boh-Gol-Zhee” in Korea, have been used traditionally as a medicinal remedy. We investigated whether an extract of PCS has protective effects on oxidative stress and mitochondrial function in hepatocytes. The PCS extract showed an antisenescence effect on human diploid fibroblasts as evidenced by a decreased expression of p16INK4a mRNA and senescence-associated β-galactosidase staining. PCS extract treatment reduced H2O2-induced reactive oxygen species (ROS) production in HepG2 cells, inhibited ROS production in hepatocytes of aged mice, and increased superoxide dismutase activity. In H2O2-treated HepG2 cells, PCS extract treatment recovered ATP production. PCS extract treatment recovered the oxygen consumption rate and inhibited reduction of mitochondrial membrane potential induced by oxidative stress, suggesting improvement of mitochondrial function. In addition, PCS extract treatment recovered peroxisome proliferator-activated receptor γ coactivator 1α and carnitine palmitoyltransferase 1 mRNA and protein expression, and inhibited mitochondrial genome damage. Treatment with the major component of PCS extract, bakuchiol, also recovered mitochondrial dysfunction. On the basis of these results, we conclude that PCS extract inhibits ROS production and mitochondrial dysfunction induced by oxidative stress in hepatocytes.

show abstract

“…In most cases, toxic organic compounds can give rise to the increased activities of antioxidant enzymes such as SOD, POD or ascorbate peroxidase (APX), which reflect not only the degree of toxicity but the ability to tolerate the stress as well (Wu and Von Tiedemann 2002;Peixoto et al 2006;Song et al 2007). Additionally, nonenzymatic (e.g., glutathione, tocopherols, ascorbate, and carotenoids) defense systems protect cells from injury also, by scavenging ROS (Pinto et al 2003;Jan et al 2012a).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative stress in Vigna radiata L. in response to chlorpyrifos

Parween

Jan

Mahmooduzzafar

et al. 2012

Int. J. Environ. Sci. Technol.

View full text Add to dashboard Cite

Anti-oxidant modulation in response to gamma radiation induced oxidative stress in developing seedlings of Psoralea corylifolia L.

Cited by 56 publications

References 63 publications

Psoralea corylifoliaL. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

Psoralea corylifoliaL. Seed Extract Ameliorates Streptozotocin-Induced Diabetes in Mice by Inhibition of Oxidative Stress

Protective Role ofPsoralea corylifoliaL. Seed Extract against Hepatic Mitochondrial Dysfunction Induced by Oxidative Stress or Aging

Evaluation of oxidative stress in Vigna radiata L. in response to chlorpyrifos

Contact Info

Product

Resources

About