Anti‐oxidant enzymes and related elements in term and preterm newborns

Nassi, Niccolò; Ponziani, Vanessa; Becatti, Matteo; Galvan, P; Donzelli, Gianpaolo

doi:10.1111/j.1442-200x.2008.02662.x

Cited by 72 publications

(63 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of this study indicate markedly lower antioxidant status of preterm newborns at birth, compared with fullterms, resulting in decreased SOD and GPX activities. This finding is in perfect accordance with the previous data published by other investigators (23)(24)(25)(26)(27), and could be explained by the inadequate supply of specific cofactors, essential for the proper functioning of these enzymes: copper, zinc and selenium, respectively; since placental maternal-to-fetal passage is very limited before (the latter part of) the third trimester (28). Production and activity of antioxidant enzymes increase markedly in the final days before birth, and even more so after birth (29).…”

Section: Discussionsupporting

confidence: 94%

Cord Blood Superoxide Dismutase and Glutathione Peroxidase Activity in Premature Infants / Aktivnost Superoksid-Dismutaze I Glutation-Peroksidaze Kod Prevremeno Rodene Dece

Guržanova-Durnev¹,

Zisovska²,

Dosić-Markovska³

2013

Journal of Medical Biochemistry

View full text Add to dashboard Cite

SummaryBackground: Birth involves strong oxidative stress for the infant, implying an increased production of free radicals. The aims of this study were to assess the antioxidant response to oxidative insult at birth, by estimating the superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity in umbilical cord blood, and to evaluate their dependency on the degree of maturation of the newborns. Methods: In the present study, 60 preterm infants (study group) as well as a full-term healthy reference group (A=53) were included. Additionally, the preterms were divided in 3 groups according to their condition at the end of the 1st week of life: preterm control (B=25), on oxygen support (C=18), and ventilated group (D=17). Results: The obtained results indicate markedly lower antioxidant capacity of the preterm infants: they had significantly lower SOD and GPX activity than the full-term infants (p<0.001, for both). Investigated antioxidants also showed significant differences between the groups of preterms. SOD activity was higher in preterms with postnatal respiratory failure compared to preterm control (p<0.001). On the contrary, GPX activity was decreased in the oxygen supported group (10%) and even more in the ventilated group (28.5%) (p<0.001, for both). The newborns enzyme activities were also profoundly modulated by the gestational age and birth weight, specifically the GPX.

show abstract

Section: Discussionsupporting

confidence: 94%

Cord Blood Superoxide Dismutase and Glutathione Peroxidase Activity in Premature Infants / Aktivnost Superoksid-Dismutaze I Glutation-Peroksidaze Kod Prevremeno Rodene Dece

Guržanova-Durnev¹,

Zisovska²,

Dosić-Markovska³

2013

Journal of Medical Biochemistry

View full text Add to dashboard Cite

show abstract

“…Although this correlation is weak, we studied only children under 7 years of age; thus, the strength of the correlation could be higher if this tendency is maintained during the rest of the pediatric age range. Previously, only a lower erythrocyte SOD activity has been reported in preterm newborns [10], which could be related to the presence of oxidative stress-related diseases in these patients, such as bronchopulmonary dysplasia. The clinical implications of these findings are yet to be established.…”

Section: Discussionmentioning

confidence: 86%

Oxidative stress biomarkers in pediatric sepsis: a prospective observational pilot study

et al. 2016

View full text Add to dashboard Cite

Objectives: Oxidative stress is known to participate in the progression of sepsis. Definite data regarding the behavior of oxidative stress biomarkers in pediatric sepsis is still lacking. This study hypothesized that oxidative stress occurs in pediatric sepsis and that the magnitude of the redox derangement is associated with worse clinical progression. Methods: Forty-two previously healthy pediatric patients with sepsis and a group of control subjects were included. Oxidative stress and inflammatory activity biomarkers were determined in blood samples. Patients were prospectively followed until their discharge or death. Results: Patients with non-severe and severe sepsis showed higher levels of plasmatic antioxidant capacity, lower erythrocyte thiol index, lower superoxide dismutase and catalase activities, higher glutathione peroxidase activity, and higher plasmatic F 2 -isoprostanes concentration than controls. Patients with severe sepsis had higher NF-kappaB activation than those with non-severe sepsis. Although we observed changes in some biomarkers in patients with worse clinical evolution, the explored biomarkers did not correlate with clinical estimators of outcome. Discussion: Oxidative stress occurs in pediatric sepsis, resulting in oxidative damage. The explored biomarkers are not useful as outcome predictors in the studied population. The behavior of these biomarkers still needs to be addressed in broader groups of pediatric patients with sepsis.

show abstract

“…In Aycicek's study, only full term infants were enrolled in the study, but we evaluated both full and late preterm infants (>35 gestational weeks) in our study. In the literature there are a number of studies that show that oxidant stress is higher in preterms than term infants 19,20 but there are no studies involving late preterms. The second cause might be the difference in placement of the phototherapy lamps: we put the phototherapy devices 30 cm above the infants, whereas Aycicek's group put them 40 cm above the infants.…”

Section: Discussionmentioning

confidence: 99%

Comparison of total oxidant/antioxidant status in unconjugated hyperbilirubinemia of newborn before and after conventional and LED phototherapy: A prospective randomized controlled trial

Demırel

Uraş²,

Çelik³

et al. 2010

CIM

View full text Add to dashboard Cite

Clin Invest Med 2010; 33 (5): E335-E341. AbstractPurpose: We evaluated and compared the oxidant and antioxidant status of hyperbilirubinemic infants before and after the two forms of phototherapy: conventional and LED phototherapy, in order to identify the optimal treatment method. Method: Thirty newborns exposed to conventional (Group I) phototherapy and 30 infants exposed to LED phototherapy (Group II) were studied. The serum total antioxidant capacity (TAC) and the total oxidant status (TOS) were assessed by EREL's method. Results: There were no statistically significant differences in TAC or TOS levels between Group I and Group II prior to phototherapy, and no statistically significant difference in TAC levels between the two groups after phototherapy; however, TOS levels were significantly lower in Group II compared to Group I after phototherapy. Oxidative stress index (OSI) increased after conventional phototherapy (p<0.05) Conclusion: The increase in TOS following conventional phototherapy was not not observed following LED phototherapy. This difference should be considered when using phototherapy.Most newborns become clinically jaundiced during the first week of life. Bilirubin is normally cleared from the body by hepatic conjugation with glucuronic acid and eliminated in bile in the form of bilirubin glucuronides, but since the neonatal liver can not adequately clear bilirubin, bilirubin accumulation is observed. High levels of bilirubin are toxic to the central nervous system, so rapid intervention is necessary.

show abstract

Anti‐oxidant enzymes and related elements in term and preterm newborns

Abstract: The nutritional status of the elements related to the anti-oxidant enzymes, especially zinc and copper, should be carefully assessed in preterm infants, even if their birthweight is not extremely low.

Cited by 72 publications

References 29 publications

Cord Blood Superoxide Dismutase and Glutathione Peroxidase Activity in Premature Infants / Aktivnost Superoksid-Dismutaze I Glutation-Peroksidaze Kod Prevremeno Rodene Dece

Cord Blood Superoxide Dismutase and Glutathione Peroxidase Activity in Premature Infants / Aktivnost Superoksid-Dismutaze I Glutation-Peroksidaze Kod Prevremeno Rodene Dece

Oxidative stress biomarkers in pediatric sepsis: a prospective observational pilot study

Comparison of total oxidant/antioxidant status in unconjugated hyperbilirubinemia of newborn before and after conventional and LED phototherapy: A prospective randomized controlled trial

Contact Info

Product

Resources

About