Anti-oxidant effects of the extracts from the leaves of Chromolaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine–xanthine oxidase induced damage

Thang, Phan Toan; See, Patrick; Teik, Lee Seng; Chan, Sui Yung

doi:10.1016/s0305-4179(00)00137-6

Cited by 101 publications

(57 citation statements)

References 23 publications

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“…[21] It was revealed that the extracts played an important role in a biological free-radical-scavenging system and made a positive contribution to promote wound-healing. Extracts from the leaves of C. odorata displayed enhanced proliferation of Combretaceae [24] fibroblasts, endothelial cells and keratinocytes, stimulation of keratinocyte migration in an in vitro wound assay, upregulation of production by keratinocytes of extracellular matrix proteins and basement membrane components, and inhibition of collagen lattice contraction by fibroblasts.…”

Section: Plants Possessing Both Wound-healing and Antioxidant Propertiesmentioning

confidence: 99%

“…Extracts from the leaves of C. odorata displayed enhanced proliferation of Combretaceae [24] fibroblasts, endothelial cells and keratinocytes, stimulation of keratinocyte migration in an in vitro wound assay, upregulation of production by keratinocytes of extracellular matrix proteins and basement membrane components, and inhibition of collagen lattice contraction by fibroblasts. [21] This plant is also rich in antioxidant flavonoids.…”

Section: Plants Possessing Both Wound-healing and Antioxidant Propertiesmentioning

confidence: 99%

“…[12] Research into the role of antioxidants from plants in wound-healing has been widely published. [10,13,14] This review aims to appraise published literature and evaluate whether wound-healing and antioxidant properties coexist in plants.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Wound healing and antioxidant properties: do they coexist in plants?

Süntar

Akkol

Nahar

et al. 2012

Free Radicals and Antioxidants

149

109

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Section: Plants Possessing Both Wound-healing and Antioxidant Propertiesmentioning

confidence: 99%

Section: Plants Possessing Both Wound-healing and Antioxidant Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Wound healing and antioxidant properties: do they coexist in plants?

Süntar

Akkol

Nahar

et al. 2012

Free Radicals and Antioxidants

149

109

View full text Add to dashboard Cite

“…Research on topical administration of natural ingredients that have antioxidant activity proved to improve the process of wound healing and prevent tissue damage due to oxidative stress [17,18].…”

Section: Discussionmentioning

confidence: 99%

Ellagic Acid Activity in Healing Process of Incision Wound on Male Albino Rats (Rattus norvegicus)

Primarizky

Yuniarti

Lukiswanto

2017

KLS

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This study was conducted to prove whether ellagic acid can be used as a regulator of incision wound healing process in male albino rats as experimental animals. A total of 24 male healthy rats based on physical examination, aged at 3 months old and weight at 150-180 grams used in this study. Rats were divided into three groups and each group has 8 replications, group of control (P0) has no incision wound and no medication, treatment group (P1) has incision wound and treated with Betadine® and (P2) has incision wound and treated with 2,5 % ellagic acid. The variable that observed are histopathology changes (collagen, PMN, angiogenesis and fibrosis) from the male albino rats. The samples collection was taken at day 15 and data were collected and analyzed by Analysis of Variance (ANOVA) test. The result of collagen and PMN cells score in the control group (P0) were 1.80 ± 0.16 and 1.6 ± 0.08 with mild angiogenesis and no fibrosis. The results in the treatment (P2) group, where the collagen and PMN scores were 1.60 ± 0.08 and 1.5 ± 0.8, accompanied by mild angiogenesis and fibrosis. Meanwhile, in the treatment (P1) group, the results of scoring of collagen and PMN were lower than the other groups, 0, 80 ± 0.08 and 0.6 ± 0.16 accompanied by moderate angiogenesis and fibrosis. There was a significant difference of collagen scoring, PMN cells number, fibrosis and angiogenesis among the treatment groups (p<0.05). P1 treatment group has significant different with treatment groups P0 and P2 (p<0.05), but there is no significant difference between treatment groups P0 and P2 (p>0.05). From the results, it can be concluded that the topical application of ellagic acid ointment was proved to provide healing process on incision wound. Topical administration of ellagic acid ointment for 14 days was able to improve the skin condition and promoted the wound healing.

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“…Traditionally, fresh leaves or a decoction of C. odorata have been used throughout Vietnam for many years as well as in other tropical countries for the treatment of inflammation, leech bite, soft tissue wounds, burn wounds, skin infection and dento-alveolitis. 1) A number of studies demonstrated that the extract of the leaves of C. odorata inhibited the growth of bacteria, [2][3][4][5] enhanced hemostasis and blood coagulation, 2,6) inhibited the contraction of collagen, 7) enhanced fibroblasts and endothelial cell proliferation. 8) The antifungal, 9) and antiinflammation 10) of the plant extract were also investigated.…”

mentioning

confidence: 99%