Anti-oxidant and Anti-inflammatory Activity of Cassia auriculata (Flowers)

Muruganantham, N.; Solomon, Shawn; Senthamilselvi, M. M.

doi:10.9734/bjpr/2015/18059

Cited by 7 publications

(9 citation statements)

References 14 publications

(18 reference statements)

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“…Since ancient times, different parts of the cucumber plant have been employed in Ayurvedic medicine, among these, fruits are traditionally used to alleviate skin problem such as sunburn’s irritation and inflammation [ 20 , 21 ]. Recently in vitro evidences [ 22 ] suggested that a Cucumis sativus extract show strong anti-oxidant capacity and ability to stability the membrane of human red blood. Moreover, Patil [ 23 ] demonstrated that aqueous extracts of Cucumis sativus is efficacious on inflammatory model of ulcerative colitis in in vivo model of Wister rats.…”

Section: Introductionmentioning

confidence: 99%

Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells

Bernardini

Zannoni

Bertocchi

et al. 2018

BMC Complement Altern Med

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BackgroundIt is widely accepted the key role of endothelium in the onset of many chronic and acute vascular and cardiovascular diseases.In the last decade, traditional compounds utilized in “folk medicine” were considered with increasing interest to discover new bioactive molecules potentially effective in a wide range of diseases including cardiovascular ones. Since ancient times different parts of the Cucumis sativus L. plant were utilized in Ayurvedic medicine, among these, fruits were traditionally used to alleviate skin problem such as sunburn irritation and inflammation. The main purpose of the present research was, in a well-defined in vitro model of endothelial cells, to investigate whether a water/ethanol extract of Cucumis sativus L. (CSE) fruit can attenuate the damaging effect of pro-inflammatory lipopolysaccharide (LPS).MethodsCell viability, gene expression of endothelial cell markers, cytokines secretion and in vitro angiogenesis assay were performed on porcine Aortic Endothelial Cells exposed to increasing doses (0.02; 02; 2 mg/ml) of CSE in the presence of pro-inflammatory lipopolysaccharide (LPS 10 μg/ml).ResultsCSE reduced LPS-induced cytotoxicity and decreased the cellular detachment, restoring the expression of tight junction ZO-1. The increase of TLR4 expression induced by LPS was counterbalanced by the presence of CSE, while the protective gene Hemeoxygenase (HO)-1 was increased. Cucumis sativus L. inhibited the early robust secretion of inflammatory IL-8 and GM-CSFs, furthermore inhibition of inflammatory IL-6 and IL-1α occurred late at 7 and 24 h respectively. On the contrary, the secretion of anti-inflammatory IL-10, together with IL-18 and IFN-γ was increased. Moreover, the in vitro angiogenesis induced by inflammatory LPS was prevented by the presence of Cucunis sativus L. extract, at any doses tested.ConclusionsOur results have clearly demonstrated that Cucumis sativus L. extract has attenuated lipopolysaccharide-induced inflammatory response in endothelial cells.

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Section: Introductionmentioning

confidence: 99%

Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells

Bernardini

Zannoni

Bertocchi

et al. 2018

BMC Complement Altern Med

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“…At the top of the phytonutrient list for cucumbers are its cucurbitaceous, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammatory, and anti-cancer benefits (Muruganantham et al, 2016). Organic manure play direct role in plant growths as source of all necessary macro and micro nutrients in available forms during mineralization and improving physical and chemical properties of soils (Chaterjee et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of NPK fertilizer and cocoa pod-based manures on soil chemical properties, growth and cucumber yield in Guinea Savannah

Dunsin¹,

Aboyeji²,

Adekiya³

et al. 2018

Agro-Sci.

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A field experiment was conducted at the Teaching and Research Farms of Landmark University Omu-Aran, Kwara State of Nigeria, for comparative evaluation of inorganic fertilizer with sole and integrated forms of cocoa pod ash (CPA) and cocoa pod husk powder (CPHP) on soil chemical properties, growth and yield of cucumber in Southern Guinea Savannah Zone of Nigeria. The treatments used for the experiment were control, NPK 20:10:10 (200 kg/ha), 100 % CPA (10 t/ha), 100 % CPHP (10 t/ha), 100 % CPA (10 t/ha) + 100 % CPHP (10 t/ha), 100 % CPA (10 t/ha) + 50 % CPHP (5 t/ha), 50 % CPA + 100% CPHP, and 50 % CPA + 50 % CPHP. At two weeks after planting NPK 20:10:10 was applied to the assigned plots at the rate of 200 kg/ha. Treatments were arranged in Randomised Complete Block Design (RCBD), replicated three times. Data collected were subjected to analysis of variance using SPSS procedure while DMRT at 5% level of probability was used to separate the means. Results showed that treatment with 10 t/ha CPA + 10 t/ha CPHP increased soil chemical properties compared to control. Treatments with 100% CPA + 100% CPHP and 100% CPA + 50% CPHP gave significantly higher and similar values of plant height, number of leaves, number of lateral branches and other yield parameters (fruit number, fruit length, fruit girth, fruit weight and total yield) of cucumber compared to the control. Therefore, the application of 10 t/ha CPA + 5 t/ha CPHP was considered best for growing cucumber in the study area. These cocoa wastes are readily available and eco-friendly compared to NPK that is costly and which may have adverse effect on the environment.

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“…The maximum inhibition zone of 14mm was exhibited at the concentration of 900µg/ml against the Staphylococcus aureus. These results were backboned by Muruganantham et al (2015) stating that a great anti-microbial activity against bacteria and fungi was shown by the compounds isolated from the ethyl acetate fractions of the Cucumis sativus lowers. Abiodun and Adeleke (2010) reported that the excellent source of protein, fat, minerals and calcium were present at the seeds of the plant.…”

Section: Discussionmentioning

confidence: 89%

Anti-microbial activity of seed extract of Cucumis sativus L., Carica papaya L. and Annona squamosa L.

Abirami

Samrot

et al. 2020

ijrps

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In recent days, threat related to infectious and antibiotic-resistant pathogens are increasing widely, and this created an urge to search for an alternative way of producing drugs. The sources selected for the production of drugs must have some attributes like readily available, available in bulk quantities, easy processing and containing less or negligible toxic effects. Herbal medications and drugs derived from medicinal plants may serve as a smart and an alternate way. In this study, ethanolic seed extracts have been used from three readily available plants like Cucumis sativus L., Carica papaya L., Annona squamosa L. The antibacterial activity of ethanolic seed extracts was performed against the pathogens present in the pus sample using agar disc diffusion method. It was found that the ethanolic seed extracts of Cucumis sativus L. were found to have a maximum zone of inhibition of 14 mm at conc., of 900 µg against S. aureus, Carica papaya L. was found to have maximum inhibition of 13mm at conc., of 900µg against S. aureus and Annona squamosa showed negligible resistance to all pus pathogens. From the various bioactive compounds present in the plants, an efficient drug can be manufactured, and it may find a great place in the pharmaceutical industry.

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Anti-oxidant and Anti-inflammatory Activity of Cassia auriculata (Flowers)

Cited by 7 publications

References 14 publications

Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells

Water/ethanol extract of Cucumis sativus L. fruit attenuates lipopolysaccharide-induced inflammatory response in endothelial cells

Short-term effects of NPK fertilizer and cocoa pod-based manures on soil chemical properties, growth and cucumber yield in Guinea Savannah

Anti-microbial activity of seed extract of Cucumis sativus L., Carica papaya L. and Annona squamosa L.

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