Anti‐oncogenic Potential and Inflammation Modulatory Response of Green Synthesized Biocompatible Silver Nanoparticles

Abstract

This study presents a novel approach to synthesizing silver nanoparticles (Ag NPs) using a solution combustion synthesis (SCS) method with Catharanthus roseus (C. roseus) leaf extract. The NPs were thoroughly characterized through X‐ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive X‐ray (EDX), Transmission electron microscopy (TEM), and Selected area electron diffraction (SAED), elucidating their crystal structure. Notably, the synthesized Ag NPs exhibited a significant dose‐dependent decline in viability of the MDA‐MB 231 breast cancer cell line, with an IC50 value of 13.3 µg/mL, underscoring their potential as potent anticancer agent. Beyond cytotoxicity, the study pioneers an investigation into the biocompatibility of Ag NPs by blood hemolsysis, providing critical insights into their safety and biomedical applicability. Furthermore, this research uncovers a distinctive facet of Ag NPs, revealing their inhibitory effects on the inflammatory enzyme secretory phospholipase A2 (sPLA2), a recognized biomarker for breast cancer. The demonstrated in vitro and in vivo inhibition of sPLA2 highlights the multifaceted potential of Ag NPs in not only targeting cancer cells but also modulating inflammatory responses associated with breast cancer, positioning the study at the forefront of advancements in nanomedicine and cancer therapeutics.

Potential Anti-Tumorigenic Properties of Diverse Medicinal Plants against the Majority of Common Types of Cancer

“…In the final phase, the product was gradually cooled to room temperature after 40 min of calcination at 500 ± 10 • C. Interestingly, the MDA-MB 231 breast cancer cell line's viability significantly decreased in a dose-dependent manner when exposed to the synthesized Ag NPs. Moreover, this study reveals a unique aspect of Ag NPs: they inhibit the inflammatory enzyme secretory phospholipase A2 (sPLA2), which is known to be a breast cancer biomarker [94]. Other recent research showed that using the MTT assay, the proliferative activity of hepatocellular carcinoma (HepG2) and normal human liver (THLE3) cells treated with C. roseus AgNPs was quantified.…”