Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.)

Zitterl-Eglseer, Karin; Sosa, Silvio; Jurenitsch, J.; Schubert‐Zsilavecz, Manfred; Loggia, R. Della; Tubaro, Aurelia; Bertoldi, Michele Corrêa; Franz, Chlodwig

doi:10.1016/s0378-8741(97)00061-5

Cited by 150 publications

(113 citation statements)

References 10 publications

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“…Primary care physicians should be aware that at least 10% of their patients may have tried 1 or more forms of alternative/complementary medicine before presenting for consultation. 13,22 These herbal extracts have the potential to meet all of the requirements of appropriate medication that could be routinely used in the pediatric patient, 7,23,24 namely in vitro bacteriostatic and bacteriocidal activity against common pathogens, 25 immunostimulation ability, 26 antioxidant activity, 27 and anti-inflammatory effects. 28 They are also well-absorbed with good penetration into the tissue surrounding the tympanic membrane.…”

Section: Discussionmentioning

confidence: 99%

Naturopathic Treatment for Ear Pain in Children

2003

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ABSTRACT.Objective. Otitis media is 1 of the most frequent diseases of early infancy and childhood and 1 of the most common reasons for children to visit a physician. In the past 2 decades, there has been a substantial increase in the diagnosis of otitis media worldwide. In the United States, 93% of all children have had at least 1 episode of acute otitis media (AOM) by 7 years of age. Otalgia is the hallmark of AOM. Most affected children either complain of earache or manifest behavior that the parents interpret as indicating ear pain. Treatment of the ear pain early in the course of AOM decreases both parental anxiety and the child's discomfort and accelerates the healing process. The objective of this study was to determine the efficacy and tolerability of naturopathic versus traditional treatment for the management of otalgia commonly associated with AOM in children.Methods. The study was designed as a double-blind trial in an outpatient community clinic. A total of 171 children who were aged 5 to 18 years and had otalgia and clinical findings associated with middle-ear infection were studied. The children were randomly assigned to receive treatment with Naturopathic Herbal Extract Ear Drops (NHED) or anesthetic ear drops, with or without amoxicillin. On enrollment, the children were assigned by computer-numbered randomization to receive NHED (contents: allium sativum, verbascum thapsus, calendula flores, hypericum perfoliatum, lavender, and vitamin E in olive oil) 5 drops 3 times daily, alone (group A) or together with a topical anesthetic (amethocaine and phenazone in glycerin) 5 drops 3 times daily (group B), or oral amoxicillin 80 mg/kg/d (maximum 500 mg/dose) divided into 3 doses with either NHED 5 drops 3 times daily (group C) or topical anesthetic 5 drops 3 times daily (group D). A double-blind design was used, and all ear drops were placed in identical bottles. Treatment was initiated by the nurse in all cases. A single physician (M.S.) evaluated and treated all of the patients included in the study and recorded all of the data. The presence or absence of ear pain was assessed over 3 days with a visual analog scale. Ear pain was assessed by a specially devised observational instrument based on previous reports. One side of the instrument consisted of a linear numbered scale, from 1 (no pain) to 10 (worst possible pain), and a corresponding color scale, ranging from blue to dark red. The reverse side contained a scale of 5 facial expressions, ranging from broad smile (no pain) to a sad and crying face (worst possible pain), and a corresponding color scale, ranging from blue to dark red.Results. There were no significant between-group differences in patient age or gender, degree of fever, main symptoms, associated symptoms, and severity or laterality of acute otitis media. Each group had a statistically significant improvement in ear pain over the course of the 3 days. Patients who were given ear drops alone had a better response than patients who were given ear drops together with amoxicillin. Results...

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Section: Discussionmentioning

confidence: 99%

Naturopathic Treatment for Ear Pain in Children

2003

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“…16) Each mouse received 15 ml of an acetone solution of croton oil on the inner surface of the right ear (75 mg croton oil/ear). After 6 h, the animals were sacrificed by cervical dislocation, and thickness of the ears was measured by a dial thickness gauge.…”

mentioning

confidence: 99%

Antiallergic and Anti-inflammatory Properties of the Ethanolic Extract from Gleditsia sinensis.

Dai

Chan

Chu

et al. 2002

Biological & Pharmaceutical Bulletin

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In traditional Chinese medicine, various parts of Gleditsia sinensis LAM. (Leguminosae) are used for different remedies and express specific therapeutic values. The thorns of G. sinensis are used for the treatment of carbuncle, scabies and suppurative skin diseases, while the mature pods and anomalous fruits (fruits without seeds) are mainly used for treating apoplexy, headache, productive cough, asthma and scabies.1)The thorns of G. sinensis have been reported to show inhibitory effects on mast cell-dependent anaphylaxis and on the growth of nasopharyngeal carcinoma cells.2,3) However, little research has been done to identify the pharmacological properties of the pods and the anomalous fruits of G. sinensis.Phytochemical investigations have shown that the anomalous fruits of G. sinensis contain over ten kinds of oleananetype triterpenoidal saponins. [4][5][6] Research has demonstrated that oleanolic acid, oleanane-type triterpenoidal saponins and herb medicines rich in this kind of saponin possess antiallergic and anti-inflammatory activities. [7][8][9][10][11][12] Thus, the present study was undertaken to evaluate the effects of the 70% ethanolic extract from the anomalous fruits of G. sinensis on immediate allergic reactions and acute inflammation. MATERIALS AND METHODS Preparation of ExtractThe anomalous fruits of Gleditsia sinensis were purchased from an herbal market in Nanjing, China in October 2001. A voucher specimen (Dai 0103) is deposited in the Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University. Two hundreds grams of Gleditsia sinensis fruits were ground and refluxed with 70% ethanol (1.5 l) three times for 1 h. After filtration through filter paper, the clear supernatant was concentrated under reduced pressure at 45°C with a vacuum rotary evaporator, and lyophilized to give a dry extract (74.1 g). The extract (AFGS) was freshly prepared in distilled water or physiological buffer saline (PBS) just before use. Chemicals and ReagentsCompound 48/80, ovalbumin (chicken egg, Grade V), croton oil, carrageenin, 5-hydroxytryptamine hydrochloride (serotonin) and indomethacin were purchased from Sigma (St. Louis, MO, U.S.A.). Inactive bacterial suspension of Bordetella pertussis, o-phthalaldehyde (OPT), prednisolone and histamine dihydrochloride were from Wako (Osaka, Japan), and disodium cromoglycate (DSCG) was from Biomol (PA, U.S.A.). Other reagents used were of analytical grade. All reagents were dissolved in distilled water for oral administration or in physiological saline for subcutaneous and intraperitoneal administration.Animals Male SD rats (weighing 180-220 g) and male ICR mice (weighing 18-20 g, 24-26 g) from the animal center of The Chinese University of Hong Kong were used. They were maintained on a standard pellet diet with free access to water, and housed in an air-contained room at 24Ϯ 2°C with lighting from 8:00 to 20:00.Systemic Anaphylactic Shock Induced by Compound 48/80 in Mice The experiment was carried out according to the method of Shin et al. 13) Mi...

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“…The fatty acids present in the C. officinalis flowers Zittwel-Eglseer et al, 1997;Wilkomirski, 1985) Erythrodiol (Wojciechowski et al, 1972) Calenduloside (Vecherko et al, 1975) (Vlchenko, 1998;Wilkomirski and Kasprzyk, 1979). The seed oil contains D-(+)-9-hydroxy-10, 12-octadecadienoic acid (oxygenated fatty acid) (Badami and Morris, 1965).…”

Section: Lipids and Fatty Acidsmentioning

confidence: 99%

“…Calendula contains various terpenoids including stigmasterols, sitosterols (Alder and Kasprzyk, 1975), lupeol, Ø-taraxasterol, 3-monoesters of taraxasterol (Wilkomirski, 1985;Zittwel-Eglseer et al, 1997), ursadiol (Sliwowski et al, 1973), diesters of diols (Wilkomirski and Kasprzyk, 1979), brein, erythrodiol (Wojciechowski et al, 1972;Kasprzyk and Wilkomirski, 1973), calenduladiol-3-O-myristate, aranidiol-3-O-myristate, calenduladiol-3-O-palmitate, aranidiol-3-O-laurate, aranidiol-3-O-palmitate (Neukiron et al, 2004;Ukiya et al, 2006), calenduloside AH (Vecherko et al, 1969(Vecherko et al, , 1971(Vecherko et al, , 1974(Vecherko et al, , 1975, calendulaglycoside A, calendulaglycoside B, calendulaglycoside C, calendulaglycoside A 6'-O-nbutyl ester, calendulaglycoside A 6'-O-n-methyl ester, et al, 2001), glucuronides (mainly present in green parts and flowers) and glucosides of oleanolic acid (mainly present in growing and senescing plants) (Ruszkowski et al, 2003;Wojciechowski et al, 1971).…”

Section: Terpenoidsmentioning

confidence: 99%

Calendula Officinalis-An Important Medicinal Plant with Potential Biological Properties

Jan¹,

John²

2017

Proceedings of the Indian National Science Academy

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Calendula officinalis L. (Marigold) is globally known for its medicinal importance containing various phyto-chemicals including carbohydrates, amino acids, lipids, fatty acids, carotenoids, terpenoids, flavonoids, quinones, coumarins and other constituents, showing some important biological activities like wound healing, immuno-stimulant, spasmogenic and spasmolytic, hepatoprotective, genotoxic and antigenotoxic, anti-amylase, anti-inflammatory, anti-oedematous, anti-bacterial and anti-fungal, antioxidant, antidiabetic, anti-HIV and anti-cancerous, nephron-protective, prevention of oropharyngeal mucositis, hypoglycemic and gastroprotective activities with no toxic effect .In this review, a detailed account of different phytochemicals and their medicinal properties of C. officinalis have been addressed.

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Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.)

Cited by 150 publications

References 10 publications

Naturopathic Treatment for Ear Pain in Children

Naturopathic Treatment for Ear Pain in Children

Antiallergic and Anti-inflammatory Properties of the Ethanolic Extract from Gleditsia sinensis.

Calendula Officinalis-An Important Medicinal Plant with Potential Biological Properties

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