Anti-obesity potential of rare sugar<scp>d</scp>-psicose by regulating lipid metabolism in rats

Chen, Jingjing; Huang, Weilai; Zhang, Tao; Lü, Mei; Jiang, Bo

doi:10.1039/c8fo01089g

Cited by 34 publications

(31 citation statements)

References 42 publications

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“…The LDL receptor is regulated through sterol regulatory elementbinding protein 2 (SREBP-2), which has an important role in hepatic cholesterol homeostasis (Hua et al, 1993). SREBP-2 is down-regulated by AMP-activated protein kinase α (AMPKα) (Wang et al, 2018), and a recent study found enhancement of AMPKα expression in D-allulosefed rats (Chen et al, 2019). These findings suggest the possibility that D-allulose might down-regulate the LDL receptor by suppression of SREBP-2 through enhancement of AMPKα expression.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels

Tanaka

Kanasaki

Hayashi

et al. 2020

Fundam. Toxicol. Sci.

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-D-allulose is one of the rare sugars with almost zero calories and several health benefits. Previous studies have reported the safety of D-allulose in normal, overweight/obese, and diabetic humans. However, one study reported significant increases in T-Cho and LDL-C after 12 weeks of D-allulose intake; this report was not a randomized controlled trial and these changes were considered to be due to seasonal variations. We, therefore, conducted a randomized, double-blind, placebo-controlled trial in 90 subjects with high LDL-C levels for 48 weeks to clarify the influence of long-term D-allulose consumption on cholesterol metabolism and efficacy. Subjects were randomly divided into 3 groups: highdose D-allulose (15 g D-allulose/day), low-dose D-allulose (5 g D-allulose/day), and placebo group (0 g D-allulose/day); each subject consumed a daily test beverage for 48 weeks. Clinical examinations were performed every eight weeks, beginning from initial consumption until week 52. No significant increases in T-Cho and LDL-C between test groups were observed, and 48 weeks of D-allulose consumption did not change risk factors for atherosclerotic cardiovascular disease. Furthermore, no clinical problems were recognized for other parameters. Additionally, significant improvements in hepatic enzyme activities, fatty liver score, and glucose metabolism after long-term D-allulose consumption were observed. The results from our study revealed that 1) D-allulose consumption is considered safe for long-term intake up to a year, and 2) D-allulose may be effective for improving hepatic functions and glucose metabolism.

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Section: Discussionmentioning

confidence: 99%

Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels

Tanaka

Kanasaki

Hayashi

et al. 2020

Fundam. Toxicol. Sci.

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“…Recently, in an attempt to produce functional foods aimed at low calorie and less sugar intake for T2D, D-psicose, a rare monosaccharide also known as D-allulose, is considered as a substitute for sugar with proven antihyperglycemic, antihyperlipidemic, and anti-inflammatory effects [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effect of functional food ingredients on gut microbiota in a rodent diabetes model

et al. 2020

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Background The gut microbiota has been shown to be involved in the development and severity of type 2 diabetes. The aim of the present study was to test the effect of 4-week functional food ingredient feeding, alone or in combination, on the gut microbiota composition in diabetic rats. Methods Streptozotocin (STZ)-induced diabetic rats were treated for 4 weeks with (1) native taro starch, (2) modified taro-starch, (3) beet juice, (4) psicose, (5) the probiotic L. plantarum IS-10506, (6) native starch combined with beet juice, (7) native starch to which beet juice was adsorbed, (8) modified starch combined with beet juice or (9) modified starch to which beet juice was adsorbed, to modulate the composition of the gut microbiota. This composition was evaluated by sequencing the PCR amplified V3–V4 region of the 16S rRNA gene. Results The next-generation sequencing showed beneficial effects particularly of taro-starch feeding. Operational taxonomic units (OTUs) related to health (e.g. correlating with low BMI, OTUs producing butyrate) were increased in relative abundance, while OTUs generally correlated with disease (e.g. Proteobacteria) were decreased by feeding taro-starch. Conclusion The results of study show that a 4-week intervention with functional food ingredients, particularly taro-derived starch, leads to a more healthy gut microbiota in rats that were induced to be diabetic by induction with STZ.

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“…Obesity is a genetic and health problem, as well as a social problem that seriously threatens human health. According to data from the World Health Organization (WHO) in 2016, 25% of adults worldwide were overweight [1,2]. Overweight and obesity can cause complications such as type 2 diabetes, high blood pressure, cancer, and non-alcoholic fatty liver disease (NAFLD) [3,4].…”

Section: Introductionmentioning

confidence: 99%

Efficiently Anti-Obesity Effects of Unsaturated Alginate Oligosaccharides (UAOS) in High-Fat Diet (HFD)-Fed Mice

Wang

2019

Marine Drugs

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Obesity and its related complications have become one of the leading problems affecting human health. However, current anti-obesity treatments are limited by high cost and numerous adverse effects. In this study, we investigated the use of a non-toxic green food additive, known as unsaturated alginate oligosaccharides (UAOS) from the enzymatic degradation of Laminaria japonicais, which showed effective anti-obesity effects in a high-fat diet (HFD) mouse model. Compared with acid hydrolyzed saturated alginate oligosaccharides (SAOS), UAOS significantly reduced body weight, serum lipid, including triacylglycerol (TG), total cholesterol (TC) and free fatty acids (FFA), liver weight, liver TG and TC, serum alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels, adipose mass, reactive oxygen species (ROS) formation, and accumulation induced in HFD mice. Moreover, the structural differences in β-d-mannuronate (M) and its C5 epimer α-l-guluronate (G) did not cause significant functional differences. Meanwhile, UAOS significantly increased both AMP-activated protein kinase α (AMPKα) and acetyl-CoA carboxylase (ACC) phosphorylation in adipocytes, which indicated that UAOS had an anti-obesity effect mainly through AMPK signaling. Our results indicate that UAOS has the potential for further development as an adjuvant treatment for many metabolic diseases such as fatty liver, hypertriglyceridemia, and possibly diabetes.

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Anti-obesity potential of rare sugard-psicose by regulating lipid metabolism in rats

Abstract: Dietary supplementation of d-psicose could slow down fat accumulation in rats by regulating lipid metabolism related genes.

Cited by 34 publications

References 42 publications

Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels

Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels

Effect of functional food ingredients on gut microbiota in a rodent diabetes model

Efficiently Anti-Obesity Effects of Unsaturated Alginate Oligosaccharides (UAOS) in High-Fat Diet (HFD)-Fed Mice

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