Anti-Obesity Effects on Unripe Rubus coreanus Miquel Extract in High Fat Diet-Induced Obese Mice

Jung, Myung; Cho, Sook-Hyun; Lee, Sun; Kim, Ji; Kim, Young-Suk; Oh, Kangho; Yoo, GooSang; Lee, Dong‐Wook; Kim, Sunoh

doi:10.9734/ijbcrr/2015/12680

Cited by 14 publications

(28 citation statements)

References 16 publications

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“…We previously reported on the antiobesity effects of the 5% ethanol extract of uRC in 3T3-L1 adipocytes and on the body weight, epididymal fat and perirenal fat weights, and lipid profiles in obese mice fed a HFD [ 19 ]. Therefore, we screened for the optimal inhibition of lipid accumulation in the organic solvent fractions of the uRC extract during adipocyte differentiation.…”

Section: Resultsmentioning

confidence: 99%

“…We previously reported that ripe R. coreanus alleviated fatigue by elevating the antioxidative potential [ 18 ]. Recently, we reported that the efficacy of the antiobesity effects of unripe R. coreanus (uRC) extract was higher than that of the ripe one in high fat diet- (HFD-) induced obese mice [ 19 ]. These results might be relevant in determining if the chemical composition changes that occur during ripening are associated with the antiobesity effects of the unripe and ripe fruits.…”

Section: Introductionmentioning

confidence: 99%

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Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism

Kim

Choi

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Background. The objective of the present study was to perform a bioguided fractionation of unripe Rubus coreanus Miquel (uRC) and evaluate the lipid accumulation system involvement in its antiobesity activity as well as study the uRC mechanism of action. Results. After the fractionation, the BuOH fraction of uRC (uRCB) was the most active fraction, suppressing the differentiation of 3T3-L1 adipocytes in a dose-dependent manner. Moreover, after an oral administration for 8 weeks in HFD-induced obese mice, uRCB (10 and 50 mg/kg/day) produced a significant decrease in body weight, food efficiency ratio, adipose tissue weight and LDL-cholesterol, serum glucose, TC, and TG levels. Similarly, uRCB significantly suppressed the elevated mRNA levels of PPARγ in the adipose tissue in vivo. Next, we investigated the antiobesity effects of ellagic acid, erycibelline, 5-hydroxy-2-pyridinemethanol, m-hydroxyphenylglycine, and 4-hydroxycoumarin isolated from uRCB. Without affecting cell viability, five bioactive compounds decreased the lipid accumulation in the 3T3-L1 cells and the mRNA expression levels of key adipogenic genes such as PPARγ, C/EBPα, SREBP-1c, ACC, and FAS. Conclusion. These results suggest that uRC and its five bioactive compounds may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism

Kim

Choi

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…The unripe R. coreanus fruits (specimen voucher number: BT-URCK001) used in this study were collected (May 2017) in Gochang County (Jeollabuk-do, Republic of Korea) and authenticated by Dr. Kim at B&Tech, Gwangju, South Korea. Extracts of the unripe R. coreanus were made using 20 volumes of 5% ethanol at 100°C for 4 h as described in our previous study [3][4][5][6]. The dried leaves of D. morbiferus (specimen voucher number: BT-DP001) used in this study were collected (December 2017) in Gangjin County (Jeollanam-do, Republic of Korea) and authenticated by Dr. Kim at B&Tech.…”

Section: Preparation Of Extractsmentioning

confidence: 99%

“…Unripe R. coreanus is a functional food or nutraceutical supplement that is useful for the prevention of noncommunicable diseases, especially cardiovascular diseases (CVDs). We previously reported the effects of a 5% ethanol extract of unripe R. coreanus (5-uRCK) on CVD-related diseases such as hyperlipidemia and obesity [3][4][5][6]. The effects of this extract may reduce the risk for CVDs, including hypertension, atherosclerosis, stroke and myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Endothelium-dependent and endothelium-independent vasorelaxant effects of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. extracts on rat aortic rings

Park

Lee

Kang

et al. 2020

BMC Complement Med Ther

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Background: Many clinical trials on antihypertensive drugs have confirmed the usefulness of these drugs in regulating blood pressure effectively. However, all the drugs usually require long-term use; thus, economic burdens as well as some adverse effects, including headache, diarrhea, skin rash, edema, fever, and liver and kidney dysfunction, accompany their use. Therefore, we attempted to identify natural medications for treating hypertension. We investigated the antihypertensive effects of Dendropanax morbiferus H. Lév. extract (DP), enzymatically hydrolyzed DP extract (Hy-DP) and 5% unripe Rubus coreanus Miq. ethanol extract (5-uRCK). Methods: Extracts of the unripe R. coreanus were made using 20 volumes of 5% ethanol at 100°C for 4 h. The dried leaves of D. morbiferus were subjected to enzymatic hydrolysis by protease, trypsin, bromelain and papain to increase Larginine and GABA levels. Vasorelaxant effects of these extracts were evaluated on rat aorta precontracted with phenylephrine. In addition, hippocampal neurons, RAW 264.7 macrophages and human umbilical vein endothelial cells (HUVECs) were used to exam nitric oxide (NO) production and NO synthase (NOS) gene expression. Results: DP, Hy-DP and 5-uRCK dose-dependently relaxed isolated rat aortic rings contracted with phenylephrine; however, Hy-DP was more effective than DP. L-NAME and ODQ differentially inhibited Hy-DP-and 5-uRCK-induced relaxation; both L-NAME and ODQ completely blocked 5-uRCK-mediated relaxation. Endothelium-denuded aortic ring relaxation was induced much less by 5-uRCK than by Hy-DP. Therefore, 5-uRCK and Hy-DP induced vascular relaxation by endothelium-dependent and partially endothelium-dependent mechanisms, respectively. Hy-DP and 5-uRCK induced eNOS gene expression and NO production in endothelial cells but did not change iNOS/nNOS expression or NO production in macrophages or neuronal cells. Both Hy-DP and 5-uRCK effectively induced vascular relaxation via similar but slightly different mechanisms. The best effective combination was investigated after mixing Hy-DP and 5-uRCK at different ratios. The 2:1 Hy-DP:5-uRCK mixture inhibited ACE, cGMP-and cAMP-dependent phosphodiesterase activity and vascular relaxation better than the other mixtures.

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“…In addition, immature black raspberry contains large amounts of ellagic acid, which can regulate the protein levels of Nrf2, NF-κB and CPT1 in an HFD-induced rat model of metabolic syndrome [26], and has anti-obesity effects [27]. Therefore, it is speculated that the anti-obesity effect in the HFD-FMIX group might be correlated with the presence of various biologically active saponins in the red ginseng extract and phenolic compounds in the black raspberry extract.…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of a Mixture of Skim Milk, Red Ginseng Extract, and Black Raspberry Extract Fermented with Lactobacillus acidophilus on High-Fat Diet-Fed Obese Mice

Yum¹,

Lee²,

Oh³

et al. 2016

J Food Chem Nanotechnol

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Anti-Obesity Effects on Unripe Rubus coreanus Miquel Extract in High Fat Diet-Induced Obese Mice

Cited by 14 publications

References 16 publications

Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism

Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism

Endothelium-dependent and endothelium-independent vasorelaxant effects of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. extracts on rat aortic rings

Anti-Obesity Effect of a Mixture of Skim Milk, Red Ginseng Extract, and Black Raspberry Extract Fermented with Lactobacillus acidophilus on High-Fat Diet-Fed Obese Mice

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