Anti-obesity Effects of SCOBY Jackfruit Beverages and Their Influence on Gut Microbiota

Koh, Soo Peng; Sew, Yun Shin; Sabidi, Sarah; Maarof, Syahida; Sharifudin, Shaiful Adzni; Abdullah, R.

doi:10.14218/erhm.2021.00072

Cited by 2 publications

(3 citation statements)

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“…Additionally, acetate and propionate have been shown to modulate hepatic lipid metabolism and improve insulin sensitivity, further underscoring the importance of SCFAs in MASLD management [50,51]. Intriguingly, previous studies have shown that jackfruit supplementation elevates the levels of SCFAs, in particular propionate, as demonstrated by the caecal GC/MS analysis [34,35]. While the current study did not directly measure the levels of these short-chain fatty acids (SCFAs) in the mice cecum or serum, our future directions aim to expand upon these findings.…”

Section: Discussionmentioning

confidence: 99%

“…Studies by Koh et al revealed that fermented jackfruit supplementation in high-fat-fed mice showed an anti-obesity effect through significant improvement in the production of SCFAs, particularly acetic acid and propionic acid [34]. Another study by Zhu et al showed that the polysaccharide from the jackfruit pulp improved the gut microbiome and significantly increased SCFA production [35]. However, SCFA production specifically attributed to green jackfruit flour remains unexplored.…”

Section: Therapeutic Effects Of Green Jackfruit Flour Are Mediated Vi...mentioning

confidence: 99%

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Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways

Suresh,

Gunaseelan,

Srinivas

et al. 2024

Preprint

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Metabolic dysfunction-associated steatotic liver disease (MASLD), encompassing metabolic-dysfunction associated steatotic liver (MAFL) and steatohepatitis (MASH), which further progresses to hepatocellular carcinoma (HCC), is a serious public health concern. Given the paucity of approved therapeutic strategies for this lifestyle disorder, dietary interventions may prove effective. We evaluated how green jackfruit flour (JF) prevents MASH and progression to HCC and its underlying mechanisms. The study utilized two murine models that mimicked human MASLD disease: (i) a diet-induced MASH model; (ii) a MASH-HCC model induced by diet and a very low dose of CCl4. C57Bl/6 mice were fed with chow (CD) or western diet (WD) with normal (NW) or sugar water (SW) for 12 weeks, then randomized to receive either 5 kcal% green jackfruit flour (JF) or an equal volume of placebo flour (PB). The biochemical, histological, and molecular analyses were assessed. JF significantly reduced body weight, liver injury, insulin resistance, and alleviated obesity, steatosis, inflammation, fibrosis, and tumor development in WDSW or WDSW/CCl4 mice compared to placebo groups. Furthermore, JF activated AMPK (AMP-activated protein kinase) and inhibited MAPK (mitogen-activated protein kinase) signaling pathways in MASH and MASH-HCC experimental models, respectively. This was supported by sodium propionate treatment, the primary short-chain fatty acid entering the liver from JFs soluble fiber microbial fermentation, which also regulated AMPK and MAPK signaling in cellular models of MASH and HCC, respectively. Hence, our findings present strong evidence of JFs therapeutic potential in the prevention of MASH and MASH-HCC, warranting further investigation of JFs efficacy as a dietary intervention in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Therapeutic Effects Of Green Jackfruit Flour Are Mediated Vi...mentioning

confidence: 99%

Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways

Suresh,

Gunaseelan,

Srinivas

et al. 2024

Preprint

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“…As a result, green tea's anti-obesity effects in HFD-induced obesity include overexpression of glucose transporter-4, reduction in absorption, and inhibition of digestive enzymes. In another report, a comparison of commercial anti-obesity medicine, orlistat (11.3%), was performed with SCOBY jackfruit drinks and suggested that jackfruit drinks significantly improved weight management control in HFD-fed obese mice and caused considerable body weight reduction (18.5-20.2%) [227]. Blood composition and signs of inflammation in medicated obese mice showed no negative consequences.…”

Section: Application Of Phytonutrient-based Anti-obesity Food Supplem...mentioning

confidence: 99%

A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity

Siddiqui,

Azmy Harahap,

Suthar

et al. 2023

Foods

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Obesity is a complex medical condition mainly caused by eating habits, genetics, lifestyle, and medicine. The present study deals with traditional diets like the Mediterranean diet, Nordic diet, African Heritage diet, Asian diet, and DASH, as these are considered to be sustainable diets for curing obesity. However, the bioavailability of phytonutrients consumed in the diet may vary, depending on several factors such as digestion and absorption of phytonutrients, interaction with other substances, cooking processes, and individual differences. Hence, several phytochemicals, like polyphenols, alkaloids, saponins, terpenoids, etc., have been investigated to assess their efficiencies and safety in the prevention and treatment of obesity. These phytochemicals have anti-obesity effects, mediated via modulation of many pathways, such as decreased lipogenesis, lipid absorption, accelerated lipolysis, energy intake, expenditure, and preadipocyte differentiation and proliferation. Owing to these anti-obesity effects, new food formulations incorporating these phytonutrients were introduced that can be beneficial in reducing the prevalence of obesity and promoting public health.

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Anti-obesity Effects of SCOBY Jackfruit Beverages and Their Influence on Gut Microbiota

Cited by 2 publications

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Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways

Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways

A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity

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