Anti-obesity effects of <i>Laminaria japonica</i> fucoidan in high-fat diet-fed mice vary with the gut microbiota structure

Zhang, Xueqian; You, Ying; Wang, LiLong; Ai, Chunqing; Huang, Linjuan; Wang, Songtao; Wang, Zhongfu; Song, Shuang; Zhu, Beiwei

doi:10.1039/d2fo00480a

Cited by 13 publications

(8 citation statements)

References 54 publications

(74 reference statements)

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“…Furthermore, it has been reported that various polysaccharides can be fermented by specific intestinal bacteria or enhance the SCFAs-producing bacteria to promote the production of SCFAs, which contributed to its anti-obesity effect. 20 However, Zhang et al 21 reported that fucoidan obtained from L. japonica can relieve mice obesity via modulating gut microbiota structure, but this anti-obesity effect is not dependent on producing SCFAs by gut microbiota. In the present study, CLP administration also had no effect on SCFAs production, suggesting the anti-obesity effect of CLP was uncorrelated with the production of SCFAs, and the results were in line with the gut microbiota analyses for which the supplement of CLP had no effect on enriching SCFAs-producing bacteria (Figs 4 and 5).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it has been reported that various polysaccharides can be fermented by specific intestinal bacteria or enhance the SCFAs‐producing bacteria to promote the production of SCFAs, which contributed to its anti‐obesity effect 20 . However, Zhang et al 21 . reported that fucoidan obtained from L. japonica can relieve mice obesity via modulating gut microbiota structure, but this anti‐obesity effect is not dependent on producing SCFAs by gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

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Supplement of Caulerpa lentillifera polysaccharide by pre‐prandial gavage and free feeding demonstrates differences to prevent obesity and gut microbiota disturbance in mice

et al. 2022

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BACKGROUND Caulerpa lentillifera has received extensive attention regarding expansion of its farming and increasing consumption. In our previous study, the structure of C. lentillifera polysaccharide (CLP) was elucidated. However, little information is available about its health effects. In this study, the anti‐obesity effect of CLP was investigated by using a high‐fat diet‐induced obese mice model with two different supplementation methods. RESULTS In vitro simulated digestion results showed that CLP significantly decreased the lipid digestibility and induced the lipid droplets aggregation in the intestinal stage to inhibit the absorption of lipids. As revealed by 16S ribosomal RNA sequencing and non‐targeted metabolomics, supplement of CLP by both pre‐prandial gavage and free feeding patterns effectively prevented mice obesity via ameliorating intestinal flora disturbance and regulating bile acids circulation metabolism. Of note was that CLP administration had no effect on short‐chain fatty acids production, suggesting the anti‐obesity effect was uncorrelated with their production. Moreover, pre‐prandial administration of CLP had a better anti‐obesity effect in lowering body weight and serum lipid levels, but the free feeding resulted in a higher α‐diversity of gut microbiota. CONCLUSION The findings of this study indicate that CLP could be a potential anti‐obesity nutraceutical and that pre‐prandial supplement of CLP may be a better intake method to exhibit its hypolipidemic effect. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Supplement of Caulerpa lentillifera polysaccharide by pre‐prandial gavage and free feeding demonstrates differences to prevent obesity and gut microbiota disturbance in mice

et al. 2022

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“…The decrease in weight was mainly attributed to reduced visceral fat mass by approximately 18%. Previously, several studies have reported that fucoidan treatment successfully reduced the chance of obesity in rats (Wang et al, 2021;Zuo et al, 2022;Zhang et al, 2022b). According to Kim et al (2014b), the animal that was given an HFD and fucoidan showed less body weight increase, a lower food-efficiency ratio and less relative liver and epididymal fat content than an HFD alone.…”

Section: Physical Changes and Anti-obesity Parametersmentioning

confidence: 99%

Potential anti‐obesity effects of fucoidan from Malaysian brown seaweed (Sargassum binderi) by in vivo study

Din,

Ishak,

Maarof

et al. 2024

Int J of Food Sci Tech

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SummaryBrown seaweed is a natural source of fucoidan, a polysaccharide known for its remarkable bioactivities. This study investigated the anti‐obesity effects of fucoidan (Fsar) from Malaysian brown seaweed (Sargassum binderi) using Sprague Dawley rats. The rats were divided into four dietary groups, including normal diet (ND), high‐fat diet (HFD), HFD with orlistat (HFD‐O) and HFD with Fsar (HFD‐F) for 28 days. Results showed a significant (P < 0.05) 36% reduction in body weight gain and an 18% decrease in visceral fat mass in the HFD‐F group compared to the HFD group. Additionally, Fsar treatment also significantly (P < 0.05) reduced insulin (threefold) and leptin (1.3‐fold) levels in blood serum. Improvements in obesity‐related biomarkers by Fsar were observed with a 1.1–1.4‐fold decrease in serum lipid profiles of total cholesterol, triglycerides and low‐density lipoprotein (LDL), without causing kidney or liver toxicity. These findings highlight fucoidan's potential as an anti‐obesity, especially in the food and pharmaceutical industries.

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“…5,8 Fucoidan, a kind of sulfated polysaccharide, is mainly distributed in brown algae cell walls and has significant physiological effects such as anti-inflammation, anti-obesity, and immune regulation. 5,10,11 However, the underlying metabolic mechanism of its effects in vitro and in vivo is still unclear. It has been proved that fucoidan cannot be digested by gastrointestinal enzymes or acid liquids.…”

Section: Introductionmentioning

confidence: 99%

Ascophyllum nodosum polysaccharide regulates gut microbiota metabolites to protect against colonic inflammation in mice

et al. 2023

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Anti-obesity effects of Laminaria japonica fucoidan in high-fat diet-fed mice vary with the gut microbiota structure

Abstract: The present study amied to investigate the possible discrepancy of anti-obesity effects of fucoidan supplementation in high-fat diet-fed mice models with different gut microbiota communities.

Cited by 13 publications

References 54 publications

Supplement of Caulerpa lentillifera polysaccharide by pre‐prandial gavage and free feeding demonstrates differences to prevent obesity and gut microbiota disturbance in mice

Supplement of Caulerpa lentillifera polysaccharide by pre‐prandial gavage and free feeding demonstrates differences to prevent obesity and gut microbiota disturbance in mice

Potential anti‐obesity effects of fucoidan from Malaysian brown seaweed (Sargassum binderi) by in vivo study

Ascophyllum nodosum polysaccharide regulates gut microbiota metabolites to protect against colonic inflammation in mice

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