Anti-Obesity Effects of Chitosan and Psyllium Husk with L-Ascorbic acid in Guinea Pigs

Abstract

The aim of this study was to investigate whether L-Ascorbic acid would facilitate the anti-obesity effects of chitosan and psyllium husk in vivo. The study was carried out with male Hartley guinea pigs for 5 weeks. The results show that chitosan itself did not influence body weight gain and food efficiency ratio (FER). However, the addition of L-Ascorbic acid to chitosan decreased these parameters; the body weight gain and FER in the chitosan-2 group (high-fat diet group with 5 % chitosan containing 0.5 % L-Ascorbic acid) was significantly (p < 0.05) lower than that in F-controls (high-fat diet group), and was similar to that in controls (normal diet group). L-Ascorbic acid enhanced significantly (p < 0.05) the increases of total fecal weight and fecal fat excretion by chitosan. The addition of L-Ascorbic acid to psyllium husk did not differ from psyllium husk alone in terms of changes in weight gain, plasma lipid levels, and fat pad weight. We found that the addition of L-Ascorbic acid to chitosan influenced the reduction in body weight gain and FER, and the increase in total fecal weight and fecal fat excretion in guinea pigs fed a high-fat diet.

Graded effects of dry-feed added sodium benzoate/ascorbic acid combination on neurobehaviour, brain markers of oxidative stress, and markers of inflammation in mice

“…Therefore, it su ces to say that combining NAB with AA reverses the body weight changes that had been reported to occur with NAB alone [7,13]. Widely reported is the weight reduction ability of AA [41][42][43], with studies in humans [43]\ and guinea pigs [42] reporting the weight reduction effects of an AA-chitosan diet, supporting our observations in this study.…”

Systematic review of the mechanisms and evidence behind the hypocholesterolaemic effects of HPMC, pectin and chitosan in animal trials

“…Next, chitosan acts as a cationic polysaccharide in an acidic environment, e.g. the stomach (Tang et al, 2005;Ylitalo et al, 2002), so the positive amino groups of the fibre bind to negatively charged molecules, such as bile acids and fatty acids (Anandan et al, 2013;Anraku et al, 2010;Ausar et al, 2003;Baker et al, 2009;Choi et al, 2012;Jaffer & Sampalis, 2007;Jun et al, 2012;Kim et al, 2001;Tai, Sheu, Lee, Yao, & Chiang, 2000). This leads to higher activity of the LDL-receptor and thus lowers LDL-C plasma levels (Santas et al, 2012) (sixth mechanism).…”

“…After precipitation, the bound fattyand bile acids are inaccessible to enzymes (Hossain et al, 2007;Tai et al, 2000) and are excreted with the stool (Anandan et al, 2013;Anraku et al, 2010;Ausar et al, 2003;Baker et al, 2009;Choi et al, 2012;Sumiyoshi & Kimura, 2006). The lack of cholesterol impairs emulsifications and decreases triglyceride uptake (Jun et al, 2012;Ylitalo et al, 2002). In vitro, chitosan can bind approximately four times its own weight in lipids (Guha et al, 2005).…”

Characterization and Optimization of Chitosan Production by Aspergillus terreus

“…Its role as a soluble dietary fiber has been investigated [12] and as a nano-carrier it has been found to increase the intestinal transport [13]. Chitosan has been reported to have anti-obesity properties [14]; therefore, it has been used as a dietary supplement for weight reduction in obese individuals. This feature is back to the positively charged amino groups in chitosan that binds to the negatively charged lipids reducing their gastrointestinal uptake and lowering serum cholesterol [14].…”

“…Chitosan has been reported to have anti-obesity properties [14]; therefore, it has been used as a dietary supplement for weight reduction in obese individuals. This feature is back to the positively charged amino groups in chitosan that binds to the negatively charged lipids reducing their gastrointestinal uptake and lowering serum cholesterol [14]. Subsequently, chitosan has the potential of atherosclerotic risk reduction.…”