Anti-obesity Effect of the Flavonoid Rich Fraction from Mulberry Leaf Extract

Go, Eun Ji; Ryu, Byung Ryeol; Yang, Su Jin; Baek, Jong-Suep; Ryu, Su Ji; Kim, Hyun Bok; Lim, Jung Dae

doi:10.7783/kjmcs.2020.28.6.395

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…13 Rutin or quercetin-3-rutinoside is a flavonoid glycoside obtained from the leaves of Morus alba , and its antiobesity effect has been verified by studying the lipid accumulation mechanism in 3T3-L1 adipocyte and C57BL mouse models. 23 Both compounds, rutin, and quercetin-3-O-β-D-glucoside (Q3G), have been shown to enhance glucose uptake through the AKT-mediated insulin signaling pathway or AMP-activated protein kinase activation (AMPK) in 3T3L1 adipocytes and could potentially be used in therapy for T2DM management. 11 In addition to rutin, the leaves of Morus alba contain apigenin, quercetin-3-triglyceride, lupeol, β-sitosterol, moracetin, isoquercitrin, coumarin, volatile oil, alkaloids, amino acids, and organic acids, proving the hypoglycemic properties and their effect enhancer on diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review

et al. 2021

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Background: The objective of this review was to evaluate the medicinal potential of Morus alba leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of Morus alba leaves for the control of DM2? Methods: This systematic review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The included studies were extracted from Scopus, Pubmed, ScienceDirect, Scielo, and Google Scholar; January 2015 to July 2021. Key search terms were MeSH and DeCS: Morus alba, mulberry, hypoglycemic agent. The inclusion criteria were: studies in rats administered Morus alba leaf extracts; studies that included the dimensions of lipidemia and glycemia; studies that included indicators such as fasting glucose, postprandial glucose, glycosylated hemoglobin, triglycerides, low-density lipoproteins, total cholesterol, and insulin resistance. Exclusion criteria: studies in which Morus alba leaves were administered with other plants; studies with other parts of the Morus alba plant; proteomic studies, cancer, duplicate studies, in vitro studies, and evaluation of included studies. All included investigations were evaluated for biases. Results: Of 253 studies found, 29 were included. The extracts of Morus alba leaves at the phytochemical level improve glucose uptake. Chlorogenic acid, isoquercitrin, and quercitrin, present in the leaves of Morus alba, have hypoglycemic properties and an ameliorating effect on diabetic nephropathy. This leaf has pharmacological effects such as glucose absorption, insulin secretion production, antioxidant and anti-inflammatory agent, antihyperglycemic and antihyperlipidemic activities, and obesity management. Conclusions: Morus alba leaves have pharmacological effects on DM2 that include glucose absorption, production of insulin secretion, antioxidant agent, antihyperglycemic and antihyperlipidemic activities, and obesity control. Beyond these results, there is a lack of studies on the potential and synergistic effects of Morus alba leaves' components, limiting the possibility of a more effective therapy using the plant's leaves.

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Section: Discussionmentioning

confidence: 99%

Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review

et al. 2021

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“…The enhanced expression of brown mark genes and beige specific genes (uncoupling protein‐1, peroxisome proliferator‐activated receptor‐gamma coactivator 1 α, cell death‐inducing DFFA like effector A, PPAR‐α, PRD1‐BF‐1‐RIZ1 homologous domain‐containing protein 16, and CD137) as well as transmembrane protein 26, nuclear respiratory factor‐1, mitochondrial transcription factor A genes for mitochondrial biogenesis and carnitine palmitoyltransferase 1 and uncoupling protein‐1 through AMP‐activated protein kinase and PGC‐1α pathway in inguinal white adipose and brown adipose tissues (Cheng et al, 2021). Flavonoid‐rich fraction and rutin (1000 μg/ml) from M. alba leaves cause a marked decrease in PPAR‐ɣ, FAS, IL‐6, and TNF‐α while increasing the expression of carnitine palmitoyltransferase 1 in the treatment group (Go et al, 2020). The white mulberry leaves contain 19 known compounds, four flavonoids, four benzofuran derivatives, two lignans, two coumarins, two megastigmane glucosides, three phenolic derivatives, and two alkaloids showed in vitro anti‐adipogenic activity of mulberry compounds on 3T3‐L1 adipocytes via inhibiting the lipid accumulation (Li, Jo, et al, 2018).…”

Section: Therapeutic Effectsmentioning

confidence: 99%

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Maqsood

Saeed

Sahar

et al. 2022

Journal of Food Biochemistry

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Medicinal plants from the family Moraceae have diverse applications in agriculture, cosmetics, food, and the pharmaceutical industry. Their extensive spectrum of pharmacological activity for treating numerous inflammatory illnesses, cancer, cardiovascular diseases, and gastrointestinal problems reflects their biological and therapeutic value. This article summarizes the molecular mechanisms related to the biological implications of mulberry extracts, fractions, and isolated bioactive compounds from different parts in various health‐related ailments. Additionally, the food industry and animal nutrition applications are summarized. Phytochemicals such as steroids, saponins, alkaloids, glycosides, polysaccharides, and phenolic compounds including terpenoids, flavonoids, anthocyanins, and tannins are found in this medicinal plant. The aqueous, ethanolic, and methanolic extracts, as well as bioactive compounds, have anti‐oxidative, hypoglycemic, nephroprotective, antimicrobial, neuroprotective, anti‐mutagenic, hepatoprotective, anthelmintic, immune‐modulatory, cardioprotective, and skin protecting activities. Mulberry supplementation in food products improves the stability of phenolics, sensory properties, antioxidant activity, and antimicrobial properties. Mulberry leaves in animal feed increase the nutrient digestibility, growth parameters, antimicrobial, and antioxidant properties. Practical applications This review summarized the in vivo and in vitro biological activities of the mulberry and isolated constituents in various health conditions. In addition, the food uses such as antioxidant potential, antimicrobial, and physicochemical properties were discussed. Furthermore, in vivo studies revealed mulberry as a significant protein source and its flavonoids as potential animal foliage.

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Mulberry leaf and its effects against obesity: A systematic review of phytochemistry, molecular mechanisms and applications

Li,

Wang,

Liu

et al. 2024

Phytomedicine

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Anti-obesity Effect of the Flavonoid Rich Fraction from Mulberry Leaf Extract

Cited by 5 publications

References 42 publications

Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review

Medicinal properties of Morus alba for the control of type 2 diabetes mellitus: a systematic review

Mulberry plant as a source of functional food with therapeutic and nutritional applications: A review

Mulberry leaf and its effects against obesity: A systematic review of phytochemistry, molecular mechanisms and applications

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