Anti-obesity Effect of Phosphatidylinositol on Diet-Induced Obesity in Mice

Abstract

The aim of this study is to investigate the biodistribution of phosphatidylinositol (PI) after oral administration and its anti-obesity effect. When a suspension of radiolabeled PI was orally administered to mice and the biodistribution was examined, PI radioactivity accumulated in the liver compared to myo-inositol radioactivity at 48 h or later after administration. Then, a PI suspension was orally administered to diet-induced obesity (DIO) mice every 4 days, and the anti-obesity effect of PI was examined. As a result, PI suppressed the body weight increase of DIO mice and significantly reduced the plasma levels of aspartate aminotransferase (AST) and cholesterol. Furthermore, PI regulated the expression of some genes in the liver involved in lipid synthesis and metabolism. The present study demonstrated that PI accumulated in the liver after oral administration and exerted its anti-obesity effect on DIO by regulating the expression of certain genes involved in lipid metabolism in the liver.

Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study

“…Animals fed high-fat diets supplemented with sphingolipids or a mixture of milk phospholipids show reduced intestinal cholesterol absorption, increased fecal lipid and cholesterol outputs, and reduced liver triglycerides, serum lipids, and blood glucose, all of which are associated with altered hepatic expression of genes in cholesterol metabolism and fatty acid synthesis (18)(19)(20)(21)(22)33). Some of these effects have also been associated with hepatic accumulation of phospholipids (33). Besides the effects on hepatic gene expression, milk phospholipids also seem to effect the partitioning of lipids in classes both within and between organs (17).…”

High fat diet induced obesity is mitigated in Cyp3a-null female mice

“…An increase in long-chain fatty acids is consistent with increased storage and increased metabolism [79], perturbations in the transport of long-chain fatty acids is associated with liver disease [80], and increased SM is associated with obesity [81, 82]. However, while SM is associated with obesity, PI is associated with anti-obesity effects by regulating hepatic lipid metabolism genes [83]. Therefore, most but not all lipid markers are consistent with fatty liver disease and obesity.…”

Effects of Pregnane Glycosides on Food Intake Depend on Stimulation of the Melanocortin Pathway and BDNF in an Animal Model

“…5 Therefore, direct or indirect targeting of the central signaling network underlying hunger, satiety, and metabolic status with novel pharmacological interventions appears to be an attractive strategy in the treatment or prevention of metabolic disorders. 6,7 …”