Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats

Ono, Yuka; Hattori, Eri; Fukaya, Yukitaka; Imai, Shoji; Ohizumi, Yasushi

doi:10.1016/j.jep.2005.12.036

Cited by 298 publications

(201 citation statements)

References 30 publications

(26 reference statements)

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“…Therefore, these results suggest that an integrative method through target profile prediction and clustering analysis can be used in several ways, such as in the identification of potential active compounds in herbal compound databases and in screening for new potential uses of known herbal medicine bioactive compounds. Nelumbo nucifera leaf extract has been demonstrated to possess anti-obesity and antioxidant properties [35,36] and is commonly used for clearing heat, alleviating heatstroke and cooling and stanching blood. Nuciferine is one of the main active components of lotus leaves.…”

Section: Discussionmentioning

confidence: 99%

Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach

et al. 2016

Acta Pharmacol Sin

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Aim: Nuciferine is an aporphine alkaloid extracted from lotus leaves, which is a raw material in Chinese medicinal herb for weight loss. In this study we used a network pharmacology approach to identify the anti-tumor activity of nuciferine and the underlying mechanisms. Methods: The pharmacological activities and mechanisms of nuciferine were identified through target profile prediction, clustering analysis and functional enrichment analysis using our traditional Chinese medicine (TCM) network pharmacology platform. The antitumor activity of nuciferine was validated by in vitro and in vivo experiments. The anti-tumor mechanisms of nuciferine were predicted through network target analysis and verified by in vitro experiments. Results: The nuciferine target profile was enriched with signaling pathways and biological functions, including "regulation of lipase activity", "response to nicotine" and "regulation of cell proliferation". Target profile clustering results suggested that nuciferine to exert anti-tumor effect. In experimental validation, nuciferine (0.8 mg/mL) markedly inhibited the viability of human neuroblastoma SY5Y cells and mouse colorectal cancer CT26 cells in vitro, and nuciferine (0.05 mg/mL) significantly suppressed the invasion of 6 cancer cell lines in vitro. Intraperitoneal injection of nuciferine (9.5 mg/mL, ip, 3 times a week for 3 weeks) significantly decreased the weight of SY5Y and CT26 tumor xenografts in nude mice. Network target analysis and experimental validation in SY5Y and CT26 cells showed that the anti-tumor effect of nuciferine was mediated through inhibiting the PI3K-AKT signaling pathway and IL-1 levels in SY5Y and CT26 cells. Conclusion: By using a TCM network pharmacology method, nuciferine is identified as an anti-tumor agent against human neuroblastoma and mouse colorectal cancer in vitro and in vivo, through inhibiting the PI3K-AKT signaling pathways and IL-1 levels.

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Section: Discussionmentioning

confidence: 99%

Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach

et al. 2016

Acta Pharmacol Sin

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“…Misket üzümü ve yer fıstığında bulunan resveratrol kozmetik bileşeni olarak antioksidan ve cilt koruyucu olarak belirtilmekte 44 , diğer antioksidanlarla karşılaştırıldığı bir çalışmada UV ile artan fotoyaşlanmada matriks metalloproteinazı önemli ölçüde inhibe ederek yaşlanma karşıtı etki gösterdiği ve UVB ışınlarına diğerlerinden daha koruyucu olduğu görülmüştür 53,66,67 .Nelumbo nucifera, serbest radikallere karşı antioksidan etkisinden dolayı anti-aging krem terkibinde bulunan ve mavi lotus olarak bilinen bir bitkidir. Ayrıca in vivo çalışmalar ile obezitiye karşı da etkin olduğu gösterilmiştir 68,69,70 . Üzüm çekirdeğinde (Vitis vinifera-Vitaceae) yüksek oranda (+)-kateşinin bulunmaktadır ve bu yüzden anti-aging kozmetik formülasyonlarda kullanılmaktadır.…”

Section: Bitki Ekstreleri Ve Bileşenleriunclassified

Anti-Aging Cosmetics Approaches and Components in Products

Yapar¹,

Tanrıverdi²

2016

BSBD

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Cilt yaşlanması; iç veya dış faktörlerin veya bunların birlikteliğinin neden olduğu karmaşık biyolojik bir süreçtir. Gelişen üretim teknolojileri, farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ve yenilikçi bileşenlere dayalı yeni nesil kozmetik ürünler, temel kozmetik bakımdan ileri alternatifler sunmaktadır. İleri teknoloji kullanılarak üretilen kozmetik aktif bileşenleri, doğal kaynaklı hammaddelerin kozmetik bileşenleri olarak kullanımının artması ve farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ile geliştirilen kozmetik ürünler toplumların artan kozmetik beklentilerini karşılamayı hedeflemektedir. Bu derlemede, günümüzde bireylerin dış ve iç faktörler ile artan cilt yaşlanmasının, kozmetik ürün odaklı çözümleri özellikle bileşenler açısından irdelenmiş, yaşlanma karşıtı farklı yaklaşımlar özetlenmiş ve kullanılan taşıyıcı sistemler belirtilmiştir.

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“…Up to now, many extracts and pure compounds have been identified and reported to exhibit considerable in vitro inhibitory activity against pancreatic lipase. Lipase inhibitors have been detected in different plant species, including Ligustrum purpurascens [1]; Eisenia bicyclis [2]; Nageia wallichiana [3]; Panax japonicus [4]; Salacia reticulata [5]; Acanthopanax senticosus [6] & Nelumbo nucifera [7]. Sharma et al [8] reported that 75 medicinal plants belong to different families in Korea were screened for their anti-lipase activity, using a radioactive method.…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity Potential of Selected Tropical Plants via Pancreatic Lipase Inhibition

Alias¹,

Leow²,

Ali³

et al. 2017

AOWMC

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Natural products are a vast source of potential compounds that can be developed as anti-obesity agent. One of the mechanisms of anti-obesity agents is inhibition of pancreatic lipase. Assay of 24 crude extracts for their in vitro activity against porcine pancreatic lipase (PPL) detected four extracts demonstrating high (>70%) inhibition, seven extracts had medium (30-70%) inhibition and the remaining 13 extracts exhibited low (<30%) inhibition when incubated with PPL at a concentration of 500 µg/ml for 10 min at 37°C. Phyllanthus niruri extract displayed the most potent PPL inhibitor, followed by Orthosiphon stamineus, Murraya paniculata and Averrhoa bilimbi with the IC50 value of 27.7<34.7< 41.5<55.2 µg/ml, respectively. P. niruri & O. stamineus (the best two extracts) showed noncompetitive and uncompetitive inhibition, respectively. P. niruri & O. stamineus displayed total phenolic content of 431.0 ± 0.01 and 103.0 ± 0.01 mg GAE/g dry extract, while total flavonoid content of 14.8 ± 0.07 and 21.6 ± 0.03 mg QE/g dry extract, respectively. Both P. niruri & O. stamineus extracts showed high antioxidant activity, with EC50 values of 8.4 and 26.3 µg/ml, respectively. The results suggest that P. niruri & O. stamineus may be beneficial for obesity treatment via pancreatic lipase inhibition action.

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Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats

Cited by 298 publications

References 30 publications

Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach

Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach

Anti-Aging Cosmetics Approaches and Components in Products

Anti-obesity Potential of Selected Tropical Plants via Pancreatic Lipase Inhibition

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