Anti-obesity effect of extract from fermented<i>Curcuma longa</i>L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

Kim, Ji Hye; Kim, Ok‐Kyung; Yoon, Ho‐Geun; Park, Jeongjin; You, Yanghee; Kim, Kyungmi; Lee, Yoo‐Hyun; Choi, Kyung‐Chul; Lee, Jeongmin; Jun, Woojin

doi:10.3402/fnr.v60.30428

Cited by 71 publications

(47 citation statements)

References 34 publications

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“…Previous studies have reported that HFD-induced obese animals are pathologically similar to obese humans and, thus, are suitable models for anti-obesity studies [23,24]. Similarly to the finding by Williams et al [23], C57Bl/6 mice fed with an HFD were observed to have a drastic increase in body weight until week 20, reaching an average body weight of 50 g per mouse.…”

Section: Discussionmentioning

confidence: 52%

Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Mohamad

Yeap

Kỳ

et al. 2017

Food & Nutrition Research

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Obesity has become a serious health problem worldwide. Various types of healthy food, including vinegar, have been proposed to manage obesity. However, different types of vinegar may have different bioactivities. This study was performed to evaluate the anti-obesity and anti-inflammatory effects of coconut water vinegar on high-fat-diet (HFD)-induced obese mice. Changes in the gut microbiota of the mice were also evaluated. To induce obesity, C57/BL mice were continuously fed an HFD for 33 weeks. Coconut water vinegar (0.08 and 2 ml/kg body weight) was fed to the obese mice from early in week 24 to the end of week 33. Changes in the body weight, fat-pad weight, serum lipid profile, expression of adipogenesis-related genes and adipokines in the fat pad, expression of inflammatory-related genes, and nitric oxide levels in the livers of the untreated and coconut water vinegar-treated mice were evaluated. Faecal samples from the untreated and coconut water vinegar-treated mice (2 ml/kg body weight) were subjected to 16S metagenomic analysis to compare their gut microbiota. The oral intake of coconut water vinegar significantly (p < 0.05) reduced the body weight, fat-pad weight, and serum lipid profile of the HFD-induced obese mice in a dose-dependent manner. We also observed up-regulation of adiponectin and down-regulation of sterol regulatory element-binding protein-1, retinol-binding protein-4, and resistin expression. The coconut water vinegar also reduced HFD-induced inflammation by down-regulating nuclear factor-κB and inducible nitric oxide synthase expression, which consequently reduced the nitric oxide level in the liver. Alterations in the gut microbiota due to an increase in the populations of the Bacteroides and Akkermansia genera by the coconut water vinegar may have helped to overcome the obesity and inflammation caused by the HFD. These results provide valuable insights into coconut water vinegar as a potential food ingredient with anti-obesity and anti-inflammatory effects.

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Section: Discussionmentioning

confidence: 52%

Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Mohamad

Yeap

Kỳ

et al. 2017

Food & Nutrition Research

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“…However, in our study the mRNA expression of PPARγ was reduced while the expression of lipolytic enzymes were upregulated by PE. Besides PPARγ, AMPK is also known to regulate lipolytic enzymes in adipose tissue (Kim et al., ). Even though the effect of PE on AMPK was not evaluated in our study, previous reports have suggested that rosmarinic acid activates AMPK pathway in different tissues to exert it beneficial effects (Abe, Saito, & Nogata, ; Han, Kee, & Hong, ; Jayanthy, Roshana Devi, Ilango, & Subramanian, ; Vlavcheski, Naimi, Murphy, Hudlicky, & Tsiani, ).…”

Section: Resultsmentioning

confidence: 99%

“…Adipose tissue, primarily composed of adipocytes, is the major fat‐storing tissue in the body, which expands in obesity (J. H. Kim et al., ). Hypertrophy and hyperplasia lead to adipose tissue expansion, and hypertrophy occurs before hyperplasia in the progression of obesity (de Ferranti & Mozaffarian, ; Jo et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…Lipogenesis is the process of triglyceride (TG) synthesis, which requires enzymes including acetyl CoA carboxylase (ACC) and fatty acid synthase (FAS) (Sung et al., ). Conversely, in the process of breaking down fat, known as lipolysis, adipose triglyceride lipase (ATGL) and hormone‐sensitive lipase (HSL) are required (J. H. Kim et al., ). TG is broken down into fatty acids, which then can undergo β‐oxidation, mainly in the liver.…”

Section: Introductionmentioning

confidence: 99%

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Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

Thomas

Kim

Lee

et al. 2018

Journal of Food Science

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“…Számos biológiailag aktív komponense ismert: kurkumin, demetoxikurkumin és biszdemetoxikurkumin. A Curcuma longa L. alkoholos kivonata a zsírsavszintetáz, acetil-CoA-karboxiláz, lipoproteinlipáz expressziójának csökkentésével gátolja a lipogenezist, serkenti a lipolízist és a béta-oxidációt töb-bek között a hormonszenzitív lipáz expressziójának növelésével és AMP-aktivált proteinkináz foszforilációjá-val [17].…”

Section: Az Elhízás Kezelése Az áJurvédábanunclassified

Ájurvéda az elhízás kezelésében

Korossy

Blázovics

2016

Orvosi Hetilap

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Az életmód változásával és a gyorséttermi láncok elterjedésével egyre nagyobb problémát jelent az elhízás az egész világon. Indiában a férfiak 31%-a, a nők 29%-a túlsúlyos, és az elhízás az utóbbi 11 évben növekvő tendenciát mutat. Az elhízás növeli számos betegség kialakulásának esélyét, mint például a szív-és érrendszeri betegségek, refluxbetegség, gastrointestinalis tumorok és alvási apnoe. Műtétek során a szövődményekkel még nem járó elhízás is súlyos komplikációkat okozhat. Az Ájurvédában a betegségek kialakulásáért a 3 dosha -vata, pitta, kapha -egyensúlyának felborulása a felelős. A 3 dosha aránya egyénenként változik, és meghatározza az egyéni testalkatot. Egy indiai kutatócsoport kimutatta, hogy az ájurvédikus testtípus-besorolás kapcsolatba hozható a gyulladásos és oxidatívstressz-faktorok génjeivel, a DNS-metilációval és a cardiovascularis betegségek kialakulásának esélyeivel. Orv. Hetil., 2016, 157(34), 1349-1352. Kulcsszavak: Ájurvéda, elhízás, dyslipidaemia, testtípus, DNS-metiláció Ayurveda for the treatment of obesityObesity is an increasing problem all over the world as the lifestyle changes and fast food chains gain popularity. In India, 31% of men and 29% of women are overweight, which is a growing trend over the last 11 years. Obesity increases the risk of many diseases such as cardiovascular diseases, reflux disease, gastrointestinal tumors, and sleep apnea. Obesity without complications can also cause serious complications during surgery. In Ayurveda the formation of diseases depends on the balance of the three doshas -vata, pitta, kapha. The rate of three doshas varies depending on the body constitution of the indvidual. Studies of an Indian research group have shown that Ayurvedic body type classification may be associated with genes of inflammation and oxidative stress factors, the rate of DNA methylation and development of cardiovascular diseases. Rövidítések AMP = adenozin-monofoszfát; AP-1 = activator protein-1; BMI = (body mass index) testtömegindex; CoA = koenzim-A; COX-2 = ciklooxigenáz-2; DNS = dezoxiribonukleinsav; FPG = (fasting plasma glucose concentration) éhomi plazmaglükóz-koncentráció; HDL = (high density lipoprotein) magas sűrűségű lipoprotein; HLA = humán leukocyta-antigén; HOMA-IR = homeostatic model assessment of insulin resistance; hs-CRP = (high sensitive C-reactive protein) magas ér-zékenységű C-reaktív protein; IL-1β = interleukin-1-β; IL-6 = interleukin-6; iNOS = indukálható nitrogén-monoxid-szintáz; LDL = (low density lipoprotein) alacsony sűrűségű lipoprotein; LPS = lipopoliszacharid; mRNS = messenger ribonukleinsav; NO = nitrogén-monoxid; PGE 2 = prosztaglandin E 2 ; SNP = single nucleotide polymorphism; TG = triglicerid; TNF-α = tumornekrózis-faktor-α; WHO = World Health Organization Keywords India és az elhízásAz életmód változásával és a különböző gyorséttermi láncok térhódításának köszönhetően az egész világon egyre nagyobb jelentőséggel bír az obesitas leküzdése. A WHO 2015-ös statisztikája szerint Indiában a férfiak 31%-a, a nők 29%-a túlsúlyos, s ez növe...

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Anti-obesity effect of extract from fermentedCurcuma longaL. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

Cited by 71 publications

References 34 publications

Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Dietary coconut water vinegar for improvement of obesity-associated inflammation in high-fat-diet-treated mice

Antiobesity Effects of Purple Perilla (Perilla frutescens var. acuta) on Adipocyte Differentiation and Mice Fed a High‐fat Diet

Ájurvéda az elhízás kezelésében

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