Anti‐obesity activities of fermented soygerm isoflavones by Bif idobacterium breve

Abstract

Soygerm isoflavones were subjected to fermentation by Bifidobacterium breve. Most of isoflavone glycosides (daidzin, glycitin and genistin) in soygerms were deglycosylated to their corresponding isoflavone aglycones (daidzein, glycitein and genistein) within 24 h fermentation. Fermented isoflavones significantly inhibited pancreatic lipase activity in fermentation-time and dosage dependant manner. When fermented isoflavones were orally administered with olive oil to SD rats, the triglyceride (TG) level in plasma after 2 h of ingestion was significantly lower than the control of only olive oil administered group whereas no such significant decrease in plasma TG was observed in unfermented isoflavone administered group. This result indicates that oral administration of fermented isoflavones effectively suppressed absorption of excessive lipid into a body. Addition of either unfermented or fermented soygerm isoflavones effectively inhibited adipocyte differentiation from 3T3-L1 in a dose dependent manner. In conclusion, B. breve successfully converted soygerm isoflavones into their aglycones, and these aglycones were more effective in suppressing lipid absorption as well as adipocytes differentiation than their glycosides.

Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism

“…Recent data showed that the fermented soygerm isoflavones (daidzein, genistein and glycitein) significantly inhibited pancreatic lipase activity in dose-dependent manner, thereby suppressing absorption of excessive lipid into a body. 60 These finding were in consistent with our data that is, increase in fecal TG excretion by daidzein supplementation, even if we did not measure the pancreas lipase activity. The inhibition of pancreas lipase activity can reduce the conversion of TG to monoglyceride or FFA, a final lipid form for absorption, which subsequently can inhibit the lipid absorption.…”

Anti-Diabetic Effects of a Kaempferol Glycoside-Rich Fraction from Unripe Soybean (Edamame,Glycine maxL. Merrill. ‘Jindai’) Leaves on KK-AyMice

“…The chemical shifts of compound a in the 13 C-NMR spectrum (Table 5) agree well with the values recorded in the previous study. 17) Taken together, compound a was identified as kaempferol 3…”

“…An effective treatment for type 2 diabetes and the metabolic syndrome as a cause of diabetes would clearly be of great benefit to the individual and society. 3) Flavonoids are polyphenolic compounds widely distributed throughout the plant kingdom. 4) They are important to protect plant leaves from UV rays during their growth.…”

Anti-obesity Effect of Steamed Soybean and Fermented Steamed Soybean in High-fat Diet-induced Obese ICR Mice

“…47 Isoflavone aglycones not only are absorbed faster and greater amounts in human body, but it also suppressed absorption of lipid into a body effectively than their glycoside form. [48][49] Secondly, Kim et al 23 demonstrated that L. plantarum P1201 produced higher CLA contents after fermentation of Daewon steamed soybean. Supplementation of CLA has been reported to decrease in body fat via reduction of energy intake, which may reduce body weight gain and prevent obesity.…”