Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Zang, Yanqing; Igarashi, Kiharu; Yu, Chaoqin

doi:10.1080/09168451.2014.955453

Cited by 41 publications

(26 citation statements)

References 43 publications

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“…Therefore, the actual bioactive compounds after DZ oral administration may likely be its metabolites other than DZ itself which will require further investigation. A recent study by Zang et al [15] demonstrated the positive role of the mixture of DZ and glycitin in decreasing blood glucose and serum HbA1c, which partly supported our findings.…”

Section: Discussionsupporting

confidence: 92%

“…However, Meezan et al [14] reported that intraperitoneal injection of DZ impaired glucose tolerance in ob/ob diabetic mice. Recently, Zang et al [15] demonstrated that the mixture of DZ and glycitin can efficiently decrease blood glucose and serum HbA1c in hyperglycemic mice. Although the mixture of DZ and glycitin were effective in the treatment of DM, the exact role of DZ was not distinguished in their report.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

Tian¹,

Liu²,

Liu³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

Tian¹,

Liu²,

Liu³

et al. 2016

Trop. J. Pharm Res

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“…Another study with high fat diet fed C57BL/6J mice reported the synergistic effect of daidzein and glycitin (0.06% mixture in diet, in the ratio of 3:1) in controlling diabetes and obesity‐related complications. Results showed a significant reduction in body weight gain, fat content in adipose tissue, and the levels of fasting glucose, HbA1c, insulin, and total cholesterol . In a study of C57BL/6j lean mice using radio labeled (C 14 ) glucose, Meezan et al .…”

Section: Effect Of Daidzein On T2d Pathophysiologymentioning

confidence: 99%

Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes

et al. 2018

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Over the last decades, the incidence of type 2 diabetes (T2D) is increasing substantially. Emerging evidences from epidemiological studies have shown the association between higher intake of soy isoflavones and reduced risk of T2D and its associated health risks. Daidzein, a soy isoflavone, has been found to have a promising therapeutic potential in managing T2D pathophysiology. Fermented soybean is the major source of daidzein; however, it can also be formed via the consumption of its glycosylated moiety, daidzin with subsequent hydrolysis by intestinal bacterial enzyme. Many studies reported the prophylactic effect of daidzein on the improvement of hyperglycemia, insulin resistance, dislipidemia, obesity, inflammation, and other complications associated with T2D. The molecular mechanisms underlying the action of daidzein include diverged pathways where daidzein has been shown to interact with several signaling molecules and receptors to achieve desirable effect. Although the specific molecular mechanism is still elusive, further studies are thus needed to understand it in detail. In this review, we discuss the antidiabetic potential of daidzein with respect to the evidences from various clinical, preclinical, and cell culture studies and the underlying molecular mechanism in a precise way to have a comprehensive account on this isoflavone with promising therapeutic potential. © 2018 BioFactors, 44(5):407-417, 2018.

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“…which had many potential bioactive effects (Xu et al, 2002). It has been reported that it could induce anti-obesity and anti-diabetes effects on highfat diet mice (Zang et al, 2014). In our previous study, glycitin was shown to have a protective effect on UV-induced skin photoageing in human dermal fibroblasts (Seo et al, 2014).…”

Section: Introductionmentioning

confidence: 95%

The mixture of glycitin and TDB (3-(2,4,6-trimethoxyphenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one) could ameliorate skin ageing by anti-wrinkle and anti-melanogenesis effects in dermal fibroblasts and melanocytes

Koh

Cho

2014

J Korean Soc Appl Biol Chem

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Ultraviolet (UV) radiation in sunlight can induce skin ageing and photo-carcinogenesis. UV may also induce melanin production and wrinkle formation. Recently, natural secondary compounds have been reported to have protective effects against UV light. In this study, the effects of two different compounds, glycitin and 3-(2,4,6-trimethoxyphenyl)-2,3-dihydro-1H-benzo[f] chromen-1-one (TDB), on human dermal fibroblasts and melanocytes were investigated. At first, only TDB was used on melanocyte cells to test whether it inhibited the proliferation of these cells. Then, a mixture of glycitin and TDB was tested on human dermal fibroblasts for 48 h in order to investigate its effect on proliferation, collagen production, and metalloproteinase family expression. The TDB treatment alone not only inhibited the proliferation of melanocytes but also increased extra cellular matrix production in dermal fibroblasts and cell viability. The mixture of glycitin and TDB markedly increased fibroblast proliferation and helped to maintain fibroblast viability in the face of UV-induced and H 2 O 2 -induced damages. This co-treatment also significantly promoted collagen IV expression and accelerated total collagen secretion. In addition, the metalloproteinase (MMPs) family such as MMP1, MMP2, and MMP7 were down-regulated at the transcriptional level. In conclusion, the mixture of glycitin and TDB induced fibroblast proliferation even when these fibroblasts were damaged by UV exposure and H 2 O 2 , whereas augmented collagen production and the inhibition of MMPs reduced wrinkle formation and decreased melanocyte proliferation, suggesting a potential use in UV-protective therapy.

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Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet

Abstract: To cite this article: Yanqing Zang, Kiharu Igarashi & Changqing Yu (2015) Anti-obese and antidiabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet,

Cited by 41 publications

References 43 publications

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice

Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes

The mixture of glycitin and TDB (3-(2,4,6-trimethoxyphenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one) could ameliorate skin ageing by anti-wrinkle and anti-melanogenesis effects in dermal fibroblasts and melanocytes

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