Anti-nociceptive effect of thalidomide on zymosan-induced experimental articular incapacitation

Vale, Mariana Lima; Cunha, Fernando; Brito, Gerly Anne Castro; Benevides, Verônica M.; Ferreira, Sérgio Henrique; Poole, Stephen; Ribeiro, Ronaldo A.

doi:10.1016/j.ejphar.2006.02.051

Cited by 22 publications

(22 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In fact, the cytokines TNF-α, IL-1β or IL-8 at doses which induced hypernociception and neutrophil migration did not induce oedema formation. Moreover, thalidomide and pentoxifylline, drugs that inhibit cytokine production, at doses that reduce neutrophil migration and hypernociception do not affect the oedema formation [58,67,68].…”

Section: Discussionmentioning

confidence: 98%

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Napimoga

Cavada

Alencar

et al. 2007

International Immunopharmacology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Napimoga

Cavada

Alencar

et al. 2007

International Immunopharmacology

Self Cite

View full text Add to dashboard Cite

“…Because the systemic metabolism of rats is more intense than that of humans, a 10× correction factor, commonly used in pharmacological studies, was used. Also, similar doses of thalidomide were successfully used by others in studies with experimental animals [34,42,45].…”

Section: Discussionmentioning

confidence: 99%

Thalidomide affects the skeletal system of ovariectomized rats

Kaczmarczyk-Sedlak

Folwarczna

Trzeciak

2009

Pharmacological Reports

View full text Add to dashboard Cite

Abstract:Apart from having written an inglorious chapter in the history of medicine, thalidomide is currently being intensely studied because of its multidimensional activity. The aim of this study was to examine the effects of thalidomide on the skeletal system in ovariectomized and non-ovariectomized rats. The experiments were carried out with female Wistar rats, divided into eight groups: sham-operated control rats; sham-operated rats receiving thalidomide at doses of 15, 30 or 60 mg/kg, po; ovariectomized control rats; ovariectomized rats receiving thalidomide at doses of 15, 30 or 60 mg/kg, po. The drug was administered for 4 weeks. Body mass gain and the mass of the uterus, liver, spleen and thymus were studied. Macrometric parameters and content of mineral substances, calcium and phosphorus in the femur, tibia and L-4 vertebra and histomorphometric parameters of the femur and tibia were examined. In the femur, the mechanical properties of the whole bone and of the femoral neck were examined. Thalidomide did not affect the skeletal system of the non-ovariectomized rats. Bilateral ovariectomy induced osteoporotic skeletal changes in mature female rats. The effects of thalidomide on the skeletal system of ovariectomized rats depended on the dose used. With a dose of 15 mg/kg, po, thalidomide counteracted some osteoporotic changes induced by estrogen deficiency. With a dose of 60 mg/kg, po, thalidomide intensified the destructive effects of estrogen deficiency on the rat skeletal system.

show abstract

“…In this test, a computerassisted device measures the length of time that a specific hind paw fails to touch the surface of a rotating cylinder in a 1-min period (paw elevation time). Normally, animal paw elevation time is ϳ10 -15 s. In previous experiments, incapacitation was studied in animals injected with zymosan (1 mg/animal) (47,58) into the knee joints, and in the present study, we have modified this dose to 4 mg/cavity. The period for which the hind paw failed to touch the rotating cylinder was interpreted as being proportional to the pain felt by the animal.…”

Section: Methodsmentioning

confidence: 99%

Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats

Kanashiro¹,

Pessini²,

Machado³

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Kanashiro A, Pessini AC, Machado RR, Malvar DC, Aguiar FA, Soares DM, Vale ML, Souza GEP. Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats. Am J Physiol Regul Integr Comp Physiol 296: R1631-R1640, 2009. First published February 25, 2009 doi:10.1152/ajpregu.90527.2008.-The present study investigated the febrile response in zymosan-induced arthritis, as well as the increase in PGE2 concentration in the cerebrospinal fluid (CSF), along with the effects of antipyretic drugs on these responses in rats. Zymosan intra-articularly injected at the dose of 0.5 mg did not affect the body core temperature (Tc) compared with saline (control), whereas at doses of 1 and 2 mg, zymosan promoted a flattened increase in Tc and declined thereafter. The dose of 4 mg of zymosan was selected for further experiments because it elicited a marked and long-lasting Tc elevation starting at 3 1/2 h, peaking at 5 1/2 h, and remaining until 10 h. This temperature increase was preceded by a decrease in the tail skin temperature, as well as hyperalgesia and edema in the knee joint. No febrile response was observed in the following days. In addition, zymosan-induced fever was not modified by the sciatic nerve excision. Zymosan increased PGE 2 concentration in the CSF but not in the plasma. Oral pretreatment with ibuprofen (5-20 mg/kg), celecoxib (1-10 mg/kg), dipyrone (60 -240 mg/kg), and paracetamol (100 -200 mg/kg) or subcutaneous injection of dexamethasone (0.25-1.0 mg/kg) dose-dependently reduced or prevented the fever during the zymosan-induced arthritis. Celecoxib (5 mg/kg), paracetamol (150 mg/kg), and dipyrone (120 mg/kg) decreased CSF PGE 2 concentration and fever during zymosan-induced arthritis, suggesting the involvement of PGE2 in this response.

show abstract

Anti-nociceptive effect of thalidomide on zymosan-induced experimental articular incapacitation

Cited by 22 publications

References 63 publications

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production

Thalidomide affects the skeletal system of ovariectomized rats

Characterization and pharmacological evaluation of febrile response on zymosan-induced arthritis in rats

Contact Info

Product

Resources

About