Anti-nociceptive and anti-inflammatory effects of Ferulago angulata

Abstract

Introduction: Ferulago angulata from the Apiaceae family, has high flavonoid content and is detected to have anti-nociceptive and anti-inflammatory effects. Objectives: In this study, we sought to determine the components of essential oil and to estimate total phenol and flavonoid contents of its various extracts. We also aimed to find out the anti-nociceptive and anti-inflammatory effects of essential oil, hydro-alcoholic and phenolic extracts of F. angulata aerial parts. Materials and Methods: The plant’s essential oil and extracts were prepared according to standard methods. Acetic acid, hot plate and formalin tests were used to investigate anti-nociceptive effects. Additionally, carrageenan and croton oil tests were used to evaluate anti-inflammatory effects. Results: Ferulago angulata aerial parts yielded 0.2% (v/w) yellowish essential oil. The gas chromatography/ mass spectrometry (GC-MS) of essential oil identified 82 compounds, which represented 98.9% of the essential oil. Thymol (7.9%), spathulenol (6.5%), trans-anethol (6.4%), myristicin (5.1%) and alpha-pinene (4.5%) were the main components. In acetic acid and formalin tests, the essential oil, hydro-alcoholic and phenolic extracts showed significant anti-nociceptive effects (P<0.001). In hot plate test, morphine which was used as standard drug, revealed significant anti-nociceptive effect while the plant extracts and essential oil were ineffective. High dose of the extracts and essential oil in croton oil test (P<0.001) and high dose of hydro-alcoholic and phenolic extracts in carrageenan test (P<0.05) reduced the inflammation. Conclusion: Ferulago angulata extracts and essential oil have anti-nociceptive and anti-inflammatory effects. However, further studies are needed to clarify their mechanism of actions.

Involvement of the NO/cGMP/KATP pathway in the antinociceptive effect of rosemary (Rosmarinus officinalis) essential oil in mice

“…Due to the side effects of chemical drugs, several herbal medicines have been studied for their possible antinociceptive and anti-inflammatory effects. Antinociceptive effect has been reported for various plant essential oils including Satureja hortensis, Dracocephalum kotschyi, Bunium, persicum, Ferulago angulate, zingiber officinalis (Hajhashemi et al, 2002;Golshani et al, 2004;Hajhashemi et al, 2011;Munda et al, 2018;Hajhashemi et al, 2020).…”

Radioprotective effect of a novel and green bio‐nanohybrid, chitosan/silver/cobalt complex, based on Ferulago angulate plant

“…Hence, screening of plants and natural products is a useful paradigm for radioprotection. [13][14][15] Ferulago angulate is a member of the Apiaceae family, which is used to reduce pain and inflammation traditionally. 16 There are many phenolic, flavonoid compounds and certain monoterpenes such as αand β-pinene, cis-ocimene, and borneol acetate in the leaves and stems of F. angulate.…”

“…The plant and natural products have all these qualities. Hence, screening of plants and natural products is a useful paradigm for radioprotection 13–15 . Ferulago angulate is a member of the Apiaceae family, which is used to reduce pain and inflammation traditionally 16 .…”