Anti-nociceptive and Anti-inflammatory Activities of Crotalaria pallida Aiton (Fam: Fabaceae) Leaves

Abstract

The present study was designed to evaluate the anti-nociceptive and anti-inflammatory properties of the ethanolic extract of Crotalaria pallida Aiton (Family: Fabaceae) leaves based on its traditional uses in the treatment of urinary disorders, external application as a poultice to treat painful swelling of joints and to reduce fever. The anti-nociceptive effect was assessed in mice using acetic acidinduced writhing, formalin-induced paw licking and tail immersion assays. Anti-inflammatory activity was evaluated by carrageenan induced paw oedema in rats. In acetic acid-induced writhing test, the extract at different doses (50 mg/kg and 100 mg/kg bw) significantly (p<0.001) and dose-dependently reduced pain by 37.50% and 47.70%, respectively. The extract also significantly inhibited formalininduced paw licking in mice at both the early and late phases. In the tail immersion test, the extract caused a significant inhibition of pain (64.91% inhibition after 4 hrs) at a dose of 100 mg/kg. C. pallida exhibited a considerable inhibition of paw oedema development in the carrageenan-induced oedema test. The findings of the study suggested that C. pallida leaves have significant anti-nociceptive and antiinflammatory effects, confirming the traditional uses of this plant in the treatment of various diseases associated with pain and inflammation.

Pharmacological Studies of Different Fractions of Litsea monopetala Roxb.

“…As part of our continuing investigation on medicinal plants of Bangladesh (Bulbul et al, 2017;Kupchan and Tosu, 1973) hypoglycemic and CNS depressant activities and we here in report the results of one findings.…”

Hypoglycemic and Hypolipidemic Activities of Psychotria sylhetensis Hook in Alloxan-induced Type 2 Diabetic Rats

“…Since many species from Psychotria genus contains compounds having antidiabetic activity, it is possible to have antidiabetic activity of P. silhetensis. As part of our continuing investigation on medicinal plants of Bangladesh (Bulbul et al, 2016 andBulbul et al, 2017) the crude methanol extract of P. sylhetensis leaves was studied for hypoglycemic and hypolipidemic activities for the first time.…”

Pharmacological investigations of Litsea lancifolia (Roxb.) Hook. F.

“…As part of on going investigation on medicinal plants of Bangladesh (Bulbul et al 2016(Bulbul et al , 2017, the crude methanol extract of leaves and its petroleum ether, chloroform and ethyl acetate soluble fractions of L. lancifolia were studied for the antioxidant potential in terms of total phenolic content and free radical scavenging, antimicrobial, analgesic, hypoglycemic and CNS depressant activities for the first time and the results of the preliminary investigations are reported.…”