Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role.

Cambridge, G; Rampton, D S; Stevens, Tim; McCarthy, D. A.; Kamm, MA; Leaker, Brian

doi:10.1136/gut.33.5.668

Cited by 156 publications

(80 citation statements)

References 23 publications

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“…These results are consistent with those in previous reports [2,3,[6][7][8][9], whereas Hibi and colleagues [17] reported that the frequency of ANCA by fixed-neutrophil ELISA was only 35% in Japanese patients with UC. This discrepancy seemed to be ascribed to the difference in neutrophil fixation, i.e.…”

Section: Discussionsupporting

confidence: 93%

Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type

Sobajima

Ozaki

Okazaki

et al. 1996

Clinical and Experimental Immunology

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SUMMARYWe analysed the clinical significance of ANCA in patients with ulcerative colitis. On either an indirect immunofluorescence assay or an ELISA with fixed neutrophils, 71% (25/35) of the patients were positive for ANCA. However, only half of them reacted with either cathepsin G or lactoferrin. Western blot assays revealed positive bands in 40% (10/25) of the antibody-positive patients. The sizes of the bands detected were 58, 47, 44, 40, and 28 kD. No significant correlation was found between the ANCA positivity and various variables, i.e. disease activity, extent of lesion, or treatment of the disease. The anti-cathepsin G and 28-kD positivity, however, significantly correlated with a refractory type of ulcerative colitis.

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Section: Discussionsupporting

confidence: 93%

Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type

Sobajima

Ozaki

Okazaki

et al. 1996

Clinical and Experimental Immunology

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“…10,11 TM has been identified as a putative auto-antigen of UC. Das et al 10 detected antibody reacting against porcine TM in UC sera.…”

Section: Discussionmentioning

confidence: 99%

Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

Koike

Kohda

Kuga

et al. 2001

Bone Marrow Transplant

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Summary:A 54-year-old woman with peripheral T cell lymphoma in second complete remission (CR) received an autologous peripheral blood stem cell transplant (PBSCT). Antibiotic-resistant bloody diarrhea, and fever developed 110 days after transplant. Blood and stool cultures were negative. Skin rash was not observed. Barium enema and colonoscopy showed typical features of pancolonic-type ulcerative colitis (UC). Endoscopic biopsies confirmed the diagnosis of UC. Mesalazine and immunosuppressive therapy improved symptoms dramatically. We detected serum antibodies against synthetic tropomyosin (TM) peptide when UC was diagnosed. We postulate that autoimmunity including autoreactive anti-TM antibodies may be involved in the pathogenesis of UC after autologous PBSCT in this patient. Bone Marrow Transplantation (2001) 28, 619-621.

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“…ANCA can be detected in sera from patients with a wide variety of inflammatory diseases including UC. In one study of 50 patients with UC, 54% were shown to be either p-ANCA or c-ANCA positive but none of these antibodies reacted with PR3 or MPO [18]. In another study, ANCA-positive patients with UC were followed for a year during which no evidence of glomerulonephritis was found [19].…”

Section: Case Reports Of Uc Related Nephritismentioning

confidence: 99%

Nephritis Associated with Ulcerative Colitis

Tokuyama¹,

Wakino²,

Hayashi³

et al. 2011

Ulcerative Colitis - Epidemiology, Pathogenesis and Complications

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Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role.

Abstract: Anti-neutrophil antibodies have been shown in sera from patients with a variety of inflammatory diseases. Those reacting with compo-

Cited by 156 publications

References 23 publications

Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type

Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type

Ulcerative colitis after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma

Nephritis Associated with Ulcerative Colitis

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