Anti-neutral glycolipid antibodies in encephalomyeloradiculoneuropathy

Shima, Sayuri; Kawamura, Naoki; Ishikawa, Tomomasa; Masuda, Hiromi; Iwahara, Chihiro; Niimi, Yoshiki; Ueda, Akihiro; Iwabuchi, Kazuhiza; Mutoh, Tatsuro

doi:10.1212/wnl.0000000000000015

Cited by 26 publications

(34 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…GSLs may play important roles in tuning the cross talk of signaling pathways in immune systems, by regulating their expression and release. Immune reactions to GSL antigens may be involved in the pathogenesis of autoimmune diseases, such as encephalomyeloradiculoneuropathy (EMRN), as autoantibodies against LacCer are present in patients with EMRN . The binding sites of anti‐LacCer antibody clones differ, even in LacCer‐enriched rafts , suggesting that the antigenic specificity of GSLs is complicated on plasma membranes.…”

Section: Gsl‐enriched Lipid Raft‐mediated Apoptosis and Autophagy In mentioning

confidence: 99%

The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems

et al. 2018

View full text Add to dashboard Cite

Lipid rafts formed by glycosphingolipids (GSLs) on cellular membranes play important roles in innate and adaptive immunity. Lactosylceramide (LacCer) forms lipid rafts on plasma and granular membranes of human neutrophils. These LacCer‐enriched lipid rafts bind directly to pathogenic components, such as pathogenic fungi‐derived β‐glucan and Mycobacteria‐derived lipoarabinomannan via carbohydrate‐carbohydrate interactions, and mediate innate immune responses to these pathogens. In contrast, a‐series and o‐series gangliosides form distinct rafts on CD4+ and CD8+ T cell subsets, respectively, contributing to the respective functions of these cells and stimulating adaptive immune responses through T cell receptors. These findings suggest that gangliosides play indispensable roles in T cell selection and activation. This Review introduces the involvement of GSL‐enriched lipid rafts in innate and adaptive immunity.

show abstract

Section: Gsl‐enriched Lipid Raft‐mediated Apoptosis and Autophagy In mentioning

confidence: 99%

The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The unresponsiveness or even disease exacerbation after IFN‐β might support an autoantibody‐mediated mechanism, because type I IFN potently stimulate the production of all subclasses of IgG antibodies. NF155 and neutral glycolipids have been reported as potential antigenic targets of CCPD, a reasonable suggestion given they are present in both CNS and PNS tissue. Because CCPD appears etiologically heterogeneous, more antigens common between CNS and PNS tissues might be discovered in the future.…”

mentioning

confidence: 80%

Nationwide Japanese survey shows the characteristic features of combined central and peripheral demyelination

Ogata

Yamasaki

Kira

2015

Clinical & Exp Neuroim

View full text Add to dashboard Cite

“…IgG antibodies to neutral glycolipids, such as lacytosylceramide and galactosylceramide, were found in acute‐phase sera from four patients with encephalomyeloradiculoneuropathy, which is a rare disease of unknown etiology . These antineutral glycolipid antibodies disappeared after immunomodulatory treatment, such as steroid pulse or a high dose of intravenous immunoglobulin therapy.…”

Section: Other Autoimmune Neuropathiesmentioning

confidence: 97%

“…IgG antibodies to neutral glycolipids, such as lacytosylceramide and galactosylceramide, were found in acute-phase sera from four patients with encephalomyeloradiculoneuropathy, which is a rare disease of unknown etiology. 45 These antineutral glycolipid antibodies disappeared after immunomodulatory treatment, such as steroid pulse or a high dose of intravenous immunoglobulin therapy. A total of 47 patients with other neurological disorders (eight with multisystem atrophy, four with neuromyelitis optica, 20 with CIDP and 15 with multiple sclerosis) and 28 healthy volunteers did not have reactivity against neutral glycolipids.…”

Section: Other Autoimmune Neuropathiesmentioning

confidence: 99%

Antibodies to glycoconjugates in autoimmune neuropathies

Kaida

2015

Clinical & Exp Neuroim

View full text Add to dashboard Cite

In glycoconjugates, the most likely targets for autoantibodies in such autoimmune neuropathies are glycolipids, especially N-acetylneuraminic acid-bearing glycosphingolipids termed gangliosides. Antiganglioside antibodies are often associated with clinical phenotypes. This association depends on the diverse distribution of gangliosides in the peripheral nervous system. Complement activation is the main mechanism of antiganglioside antibody-mediated nerve injury in Guillain-Barr e syndrome. Complement-independent mechanism, including dysfunction of ion channels, alteration of the integrity of lipid rafts and activating Fc gamma receptor-mediated inflammation, is likely to play a role in the development of antiganglioside antibody-mediated neuropathy. The pathogenic actions of antiganglioside antibodies are governed by their avidity, which are influenced by binding specificity of antibodies, specific localization of gangliosides in the peripheral nervous system, glycolipid environment and internalization of antibodies on nerve membranes. The discovery of antibodies to ganglioside complexes improves the detection rate of antibodies in Guillain-Barr e syndrome, as well as providing a new concept in antibodyantigen interactions through clustered carbohydrate epitopes. Antibodies to glycoconjugates are infrequent in chronic inflammatory demyelinating patients, and their pathogenic roles are unclear. In multifocal motor neuropathy, Immunoglobulin M antibodies to GM1 or GM1/galactocerebroside complex are useful diagnostic markers, and are likely to induce nerve damage through complement activation. Antibodies to neutral glycolipids, such as lacytosylceramide and galactosylceramide, might play a role in the development of encephalomyeloradiculoneuropathy, a disorder involving central and peripheral nerve tissues.

show abstract

Anti-neutral glycolipid antibodies in encephalomyeloradiculoneuropathy

Abstract: The resolution of radiologic and neurologic abnormalities and altered autoantibody titers against neutral glycolipids after immunotherapy suggest that EMRN is caused by an immune-mediated mechanism. These autoantibodies may be useful biomarkers for EMRN.

Cited by 26 publications

References 9 publications

The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems

The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems

Nationwide Japanese survey shows the characteristic features of combined central and peripheral demyelination

Antibodies to glycoconjugates in autoimmune neuropathies

Contact Info

Product

Resources

About