Anti-neuroinflammatory Effects of Active Compound SPA1413 <i>via</i> Suppression of the MAPK and JAK/STAT Signaling Pathways
Da Hye Yoon,
Seong-Min Hong,
Eun Ji Ko
et al.
Abstract:Isoflavones and their derivatives possess neuroprotective activities against neurological disorders. Recently, the active compound SPA1413 (dehydroequol) derived from S-equol, an isoflavone-derived metabolite produced by human intestinal bacteria, was identified as a potent anti-amyloidogenic and neuroinflammatory candidate against Alzheimer's disease. However, its detailed modes of action, associated signaling pathways, and comparison with potential isoflavone derivatives have not yet been studied. Hence, the… Show more
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