Anti-Neuroinflammatory Effects of a Semi-Synthetic Isoorientin-Based Glycogen Synthase Kinase-3β Inhibitor in Lipopolysaccharide-Activated Microglial Cells
Abstract:Neuroinflammation
contributes to the pathogenesis of several neurodegenerative
disorders. Glycogen synthase kinase-3β (GSK-3β) regulates
the release of proinflammatory cytokines and promotes inflammatory
responses in immune cells. Microglia are the resident mononuclear
immune cells of the central nervous system. Here, we investigated
the anti-neuroinflammatory effects of (2S,3S,4R,5R,6S)-6-(2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4-oxo-4H-chromen-6-yl)-3,4,5-trihydroxy-N-((S)-1,1,1-trifluoropropan-2-yl)tetrahyd… Show more
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