Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol

Ho, Su-Chen; Chang, Ku-Shang; Lin, Chih‐Cheng

doi:10.1016/j.foodchem.2013.06.010

Cited by 112 publications

(76 citation statements)

References 30 publications

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“…This upregulation was attenuated by gingerols, except for that of IL-1␤ and IL-2, for which there was no statistical significance. It has been demonstrated that gingerols can inhibit TNF-␣ expression in the liver, nervous system, and other tissues (16,53). Also, it is known that gingerols reduce the expression of IL-2 and IFN-␥ by T cells (54,55).…”

Section: Figmentioning

confidence: 99%

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Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

Rodrigues

Prata

Oliveira

et al. 2014

Antimicrob Agents Chemother

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. Histopathological findings of tubular degeneration and inflammatory cell infiltration reinforced GM-induced nephrotoxicity. All these alterations were attenuated by previous oral treatment with GF. Animals from the GM؉GF groups showed amelioration in renal function parameters and reduced lipid peroxidation and nitrosative stress, in addition to an increment in the levels of glutathione (GSH) and superoxide dismutase (SOD) activity. Gingerols also promoted significant reductions in mRNA transcription for TNF-␣, IL-2, and IFN-␥. These effects were dose dependent. These results demonstrate that GF promotes a nephroprotective effect on GM-mediated nephropathy by oxidative stress, inflammatory processes, and renal dysfunction.

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Section: Figmentioning

confidence: 99%

“…Although it comprises more than 85% of all gingerols administered, we cannot attribute all beneficial effects to [6]-gingerol. Recently, it was demonstrated that the less abundant compound [10]-gingerol, not [6]-gingerol, was responsible for the anti-inflammatory effects on neuronal cells (53).…”

Section: Figmentioning

confidence: 99%

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

Rodrigues

Prata

Oliveira

et al. 2014

Antimicrob Agents Chemother

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“…It improves memory by inhibiting the activity of glial cells in animal models of dementia and also by reducing memory corruption. 15 Besides, Ginger decreases activity of NF-κB, 16,17 iNOS, and Cyclooxygenase2 (COX-2).…”

Section: Ginger and Improvement Of The Neurological Degenerative Disementioning

confidence: 99%

Ginger and its Effects on Inflammatory Diseases

Aryaeian¹,

Tavakkoli²

2015

Adv Food Technol Nutr Sci Open J

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Today, Ginger is used as a spice all around the world. In the past, Ginger was consumed for the treatment of various diseases, including osteo-arthritis, neurological diseases, vomiting, asthma, and so on. It seems that Ginger can reduce inflammation in those diseases. We searched the following keywords in PubMed, Google scholar, and Scopus database until 2015: inflammation and Ginger, Ginger and diseases. Clinical trials, animal studies, and human studies were included in the results of this search. Ginger extract with the antioxidant and anti-inflammatory ingredients such as 6 Gingerols, 6-Shogoals, Zhingerol, etc can reduce inflammatory mediators such as inflammatory cytokines and chemokines due to their effects on NF-κB activation, cyclooxygenase 2 reduction and serotonin receptors inhibition. It increases reducing antioxidant enzymes so it can be useful in inflammatory diseases improvement and their complications prevention. In conclusion, Ginger can help in the treatment of inflammatory chronic diseases such as Fatty Liver, Asthma, Cancer and Arthritis through anti-inflammatory, immunoregulatory and antioxidative mechanisms.

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“…The plant is reported for antimicrobial activity, anticancer activity, antioxidant activity, antidiabetic activity, nephroprotective activity, hepatoprotective activity, larvicidal activity, analgesic activity, anti-inflammatory activity and immunomodulatory activities. 1,8,9,12,13 More than seventy pharmacology studies of Z. officinale rhizomes have been reported. Most of the secondary metabolites of herbs are commercially important and find use in a number of pharmaceutical compounds.…”

Section: Introductionmentioning

confidence: 99%

A Review: Is Ginger (Zingiber officinale var. Roscoe) Potential for Future Phytomedicine?

Syafitri¹,

Levita

Mutakin

et al. 2018

IJAS

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Zingiber officinale Roscoe (red:ginger), one of the most widely consumed herbs in Asia, has been empirically used to treat various disorders in Indonesia. There are three known types of ginger: giant ginger or white ginger (Zingiber officinale var. Roscoe), small white ginger or ginger emprit (Zingiber officinale var. Amarum), and red ginger (Zingiber officinale var. Rubrum). The main components of ginger rhizome are carbohydrates, lipids, essential oils, terpenes, and phenol compounds such as gingerol (23-25%) and shogaol (18-25%). Many studies had confirmed beneficial effects of ginger against inflammation, free radicals, diabetes mellitus, bacterial infection, cancer, nausea, etc. Z. officinale var. Roscoe is considered a safe herbal with not significant adverse effects. This plant is potential to be developed for future phytomedicine, however further explorations on its clinical studies in humans is expected, especially the efficacy and safety of the risk of side effects.

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Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol

Cited by 112 publications

References 30 publications

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

Gingerol Fraction from Zingiber officinale Protects against Gentamicin-Induced Nephrotoxicity

Ginger and its Effects on Inflammatory Diseases

A Review: Is Ginger (Zingiber officinale var. Roscoe) Potential for Future Phytomedicine?

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