Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin

Nishino, Hoyoku; Tsushima, Miyuki; Matsuno, Takao; Tanaka, Yukië; Okuzumi, Junichi; Murakoshi, Masanori; Satomi, Yoshiko; Takayasu, Junko; Tokuda, Hidemitsu; Nishino, Azusa

doi:10.1097/00001813-199210000-00008

Cited by 33 publications

(17 citation statements)

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“…For example, the sea squirt Halocynthia roretzi contains a number of carotenoids including halocynthiaxanthin, alloxanthin, diatoxanthin, mytiloxanthin and fucoxanthinol with allenic, acetylenic and epoxicide structures in the molecule 1,2) . Previous studies have shown that holocynthiaxanthin exhibits an antiproliferative effect on various tumor cells 3) , inhibition of reverse transcriptases of immunodeficiency viruses 4) , and suppression of both superoxide and nitric oxide generation 5) . We and others have also reported that halocynthiaxanthin and fucoxanthinol induce apoptosis in human leukemia, colon and breast cancer cells 6,7) .…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

et al. 2008

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To investigate anti-inflammatory effects of carotenoids from Halocynthia roretzi, gene expression levels were measured for pro-inflammatory cytokines and enzymes in the murine macrophage-like cell line, RAW264.7, stimulated with lipopolysaccharide (LPS). All-trans alloxanthin, all-trans diatoxanthin, and their 9-cis isomers isolated from H. roretzi significantly suppressed expression of IL-1b and IL-6 mRNA in cells induced by LPS without cytotoxicity. The expression level of IL-1b mRNA in cells treated with 25 mM all-trans alloxanthin for 24 h, followed by stimulation with 0.1 mg/mL LPS for 24 h in the presence of carotenoid decreased to 33.7±3.0% from that of control cells stimulated with LPS alone. All-trans diatoxanthin, 9-cis alloxanthin and 9-cis diatoxanthin also decreased expression of IL-1b mRNA to 25.1±2.1, 28.2±0.9 and 32.9±3.3%, respectively, from that of control cells stimulated with LPS. IL-1b production in culture medium was also suppressed by all-trans alloxanthin and all-trans diatoxanthin. Furthermore, all-trans alloxanthin, all-trans diatoxanthin and their 9-cis isomers suppressed the overexpression of cyclooxygenase-2 and nitric oxide synthase mRNA in RAW264.7 cells induced by LPS. The suppressive effects of these carotenoids were remarkable compared to those of b-carotene and zeaxanthin.

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Section: Introductionmentioning

confidence: 99%

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

et al. 2008

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“…Structure and biological activity of fucoxanthin and carotenoids in cancer cells [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Biological functions of carotenoids in cell membranes [19][20][21][22] Interaction of carotenoids with lipid rafts [23] Cell model to study the integration of xenobiotics into lipid rafts [24] Antioxidant and pro-oxidant activity of fucoxanthin in animal cells and tissues [25][26][27] Structure and function of lipid rafts in cell membranes [28,29] Targeting lipid rafts in cancer cells [30][31][32][33][34][35][36] Ion channels, lipid rafts and cancer cells [37,38] Lipid rafts, cytoskeleton, cancer cells invasivity and tumor angiogenesis [30,40] …”

Section: Reference Numbersmentioning

confidence: 99%

“…Particularly, fucoxanthin ( Figure 1), a marine carotenoid purified from brown micro-and macroalgae, attracts extensive interest owing to its antiproliferative, pro-apoptotic and pro-autophagic activities, demonstrated in a large panel of cancer cells [3][4][5][6][7][8][9][10][11][12][13][14]. Its antitumoral activity was validated in animal models, in which it limits tumor growth, angiogenesis and invasivity, suggesting a possible use for clinical oncology [1,15].…”

Section: Introductionmentioning

confidence: 99%

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

RG¹,

Thiery²,

Sergent³

et al. 2017

J Oceanogr Mar Res

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Fucoxanthin is a carotenoid present in brown micro-and macro algae, that induces apoptosis or autophagy in cancer cells grown in vitro. In vivo studies confirmed its interest as a natural anticancer compound, as it exerts antitumoral, antimetastatic and antiangiogenic activities in animal models. Studies focused on the pharmacology of fucoxanthin in cancer cells and tumors have revealed that it affects a wide panel of cellular, molecular and tissular processes, suggesting that its biological activity may be related in part to a nonspecific integration in cell membranes, and possible interaction with lipid rafts. Thus, preliminary data confirming this interaction of fucoxanthin with lipid rafts were obtained in mast cells and hepatoma WIF-B9 cells. We here discuss this hypothesis, in view of the critical function of lipid rafts in cancer cell survival, invasivity and communication with the tumoral microenvironment.

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“…Results from epidemiological and animal studies have indicated that a variety of carotenoids have anti-carcinogenic effects. Halocynthiaxanthin is a carotenoid contained in sea squirts and oysters that causes apoptosis [43], inhibits tumor promotion by Epstein-Barr virus (EBV) [44], and suppresses free radical generation [45]. Peridinin is also a carotenoid extracted from corbicula clams.…”

Section: Combination Of Food Components and Trailmentioning

confidence: 99%

“Combination-oriented molecular-targeting prevention” of cancer: a model involving the combination of TRAIL and a DR5 inducer

Yoshida

Horinaka

Sakai

2010

Environ Health Prev Med

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Malignant tumors carry a high risk of death, and the prevention of malignant tumors is a crucial issue in preventive medicine. To this end, many chemopreventive agents have been tested, but the effects of single agents have been found to be insufficient to justify clinical trials. We have therefore hypothesized that combinations of different chemopreventive agents may synergistically enhance the preventive effect of chemopreventive agents used singly. To provide the treating physician with some guideline by which to choose the most effective agents to be combined, we propose a strategy which we have termed the ''combination-oriented molecular-targeting prevention'' of cancer. As the molecular target of our model, we focused on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), which specifically causes apoptosis in malignant tumor cells. Many of these agents were found to up-regulate the expression of death receptor 5, a TRAIL receptor. They were also found to synergistically induce apoptosis in malignant tumor cells when combined with TRAIL. Here, we strongly advocate that the strategy of ''combination-oriented molecular-targeting prevention'' of cancer will be a practical approach for chemoprevention against human malignant tumors.

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Anti-neoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin

Cited by 33 publications

References 0 publications

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

Suppressive Effects of Alloxanthin and Diatoxanthin from Halocynthia roretzi on LPS-induced Expression of Pro-inflammatory Genes in RAW264.7 Cells

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

“Combination-oriented molecular-targeting prevention” of cancer: a model involving the combination of TRAIL and a DR5 inducer

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