Anti-Neoplastic Cytotoxicity of SN-38-Loaded PCL/Gelatin Electrospun Composite Nanofiber Scaffolds against Human Glioblastoma Cells In Vitro

Zhu, Xiaodong; Ni, Shilei; Xia, Tongliang; Yao, Qingyu; Li, Haoyuan; Wang, Benlin; Wang, Jiangang; Li, Xingang; Su, Wandong

doi:10.1002/jps.24684

Cited by 37 publications

(18 citation statements)

References 26 publications

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“…1). In detail, the articles excluded according to type classification as given by PubMed are as follows: reviews ( 358 [6,13,19,25,32,57,69] were added after reviewing the bibliographies of the included papers. A categorization of the studies according to nanofield and neurosurgical field is reported in Figs.…”

Section: Resultsmentioning

confidence: 99%

“…A nanotechnological advance, the hand-held Raman scanner, could accurately detect goldsilica surface-enhanced Raman scattering nanoparticles that are embedded in glioblastoma and thus guide a complete resection [48]. Other nanotechnological advances include nanoscaffolds and magnetic carriers, such as magnetic liposomes, that can demonstrate high specificity and efficacy in tumor growth [67,69]. Transferrin-modified nanoscaled graphene oxide doxorubicin exhibited a significantly improved effect on tumor growth [37], as well did a thermosensitive liposome which demonstrated even better results than the conventional liposomes [31].…”

Section: Cns Tumorsmentioning

confidence: 99%

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Nanotechnology in neurosurgery: a systematic review

Giakoumettis

Sgouros

2021

Childs Nerv Syst

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Background The application of nanotechnology in medicine encompasses an interdisciplinary field of sciences for the diagnosis, treatment, and monitoring of medical conditions. This study aims to systematically review and summarize the advances of nanotechnology applicable to neurosurgery. Methods We performed a PubMed advanced search of reports exploring the advances of nanotechnology and nanomedicine relating to diagnosis, treatment, or both, in neurosurgery, for the last decade. The search was performed according to PRISMA guidelines, and the following data were extracted from each paper: title; authors; article type; PMID; DOI; year of publication; in vitro, in vivo model; nanomedical, nanotechnological material; nanofield; neurosurgical field; the application of the system; and main conclusions of the study. Results A total of 78 original studies were included in this review. The results were organized into the following categories: functional neurosurgery, head trauma, neurodegenerative diseases, neuro-oncology, spinal surgery and peripheral nerves, vascular neurosurgery, and studies that apply to more than one field. A further categorization applied in terms of nanomedical field such as neuroimaging, neuro-nanotechnology, neuroregeneration, theranostics, and neuro-nanotherapy. Conclusion In reviewing the literature, significant advances in imaging and treatment of central nervous system diseases are underway and are expected to reach clinical practice in the next decade by the application of the rapidly evolving nanotechnology techniques.

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Section: Resultsmentioning

confidence: 99%

Section: Cns Tumorsmentioning

confidence: 99%

Nanotechnology in neurosurgery: a systematic review

Giakoumettis

Sgouros

2021

Childs Nerv Syst

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“… 33 , 67 However, inherently poor aqueous solubility and inherent instability at pH > 6 hamper the direct utility of SN-38; consequently, several pro-drug, polymer-conjugated micelles, fibers, particles, and implants were investigated to improve SN-38’s biopharmaceutic properties. 67 SN-38 has been loaded into various polymers, including PLGA, 33 NK-012, 68 PLEC, 69 and PCL/GT, 70 for local delivery. These drug-loaded polymers exhibited superior antitumor properties in vitro 70 and in an orthotopic animal model.…”

Section: Polymeric Vehicles For Local Drug Deliveriesmentioning

confidence: 99%

Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review

Tseng

Chen²,

Liu³

2021

IJN

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Malignant gliomas (MGs) are the most common and devastating primary brain tumor. At present, surgical interventions, radiotherapy, and chemotherapy are only marginally effective in prolonging the life expectancy of patients with MGs. Inherent heterogeneity, aggressive invasion and infiltration, intact physical barriers, and the numerous mechanisms underlying chemotherapy and radiotherapy resistance contribute to the poor prognosis for patients with MGs. Various studies have investigated methods to overcome these obstacles in MG treatment. In this review, we address difficulties in MG treatment and focus on promising polymeric local drug delivery systems. In contrast to most local delivery systems, which are directly implanted into the residual cavity after intratumoral injection or the surgical removal of a tumor, some rapidly developing and promising nanotechnological methodsincluding surface-decorated nanoparticles, magnetic nanoparticles, and focused ultrasound assist transport-are administered through (systemic) intravascular injection. We also discuss further synergistic and multimodal strategies for heightening therapeutic efficacy. Finally, we outline the challenges and therapeutic potential of these polymeric drug delivery systems.

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“…Hence, it dissolves in solvents like chloroform, acetone, acetic acid, dichloromethane, toluene, methanol, benzene and tetrachloride [10]. The properties of PCL, including biodegradability, cytotoxicity and degradation rate, have been studied elaborately with respect to short- and long-duration implants [60,61]. Degradation of PCL is non-enzymatic, and occurs by means of hydrolysis.…”

Section: Biomedical Applications Of Polymer-based Electrospun Nanomentioning

confidence: 99%

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

2019

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Electrospinning has gained wide attention recently in biomedical applications. Electrospun biocompatible scaffolds are well-known for biomedical applications such as drug delivery, wound dressing, and tissue engineering applications. In this review, the synthesis of polymer-based fiber composites using an electrospinning technique is discussed. Formerly, metal particles were then deposited on the surface of electrospun fibers using sputtering technology. Key nanometals for biomedical applications including silver and copper nanoparticles are discussed throughout this review. The formulated scaffolds were found to be suitable candidates for biomedical uses such as antibacterial coatings, surface modification for improving biocompatibility, and tissue engineering. This review briefly mentions the characteristics of the nanostructures while focusing on how nanostructures hold potential for a wide range of biomedical applications.

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Anti-Neoplastic Cytotoxicity of SN-38-Loaded PCL/Gelatin Electrospun Composite Nanofiber Scaffolds against Human Glioblastoma Cells In Vitro

Cited by 37 publications

References 26 publications

Nanotechnology in neurosurgery: a systematic review

Nanotechnology in neurosurgery: a systematic review

Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

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