Anti‐myocardial Ischemia Effect and Components of Litchi Pericarp Extracts

Chen, Yanfen; Li, Huanqing; Zhang, Shu; Yang, Chunjuan; Mai, Ziying; Hu, Xueyan; Gao, Zhenhu; Deng, Hong

doi:10.1002/ptr.5865

Cited by 13 publications

(10 citation statements)

References 27 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been proven that these phenolics have a strong scavenging ability and antioxidant capacity [10–14]. Not only that, but lychee pericarp, as a medicinal material, also has the capacity to dehumidify and stop dysentery and hemostasis, which reduces blood lipids, and has anti-cardiovascular disease [15] and anti-cancer [16–18] effects.…”

Section: Introductionmentioning

confidence: 99%

Effects of simulated digestion on the phenolic composition and antioxidant activity of different cultivars of lychee pericarp

Zeng

Dai

et al. 2019

BMC Chemistry

View full text Add to dashboard Cite

Background Lychee pericarp is rich in phenolic and has good antioxidant activity. The effects of simulated gastric (SGF) and intestinal fluid (SIF) digestion on the contents, composition, and antioxidant activities of the phenolic substances in the pericarp of different lychee cultivars (cv Jizui , Lizhiwang , Guiwei , Yuhe , Nuomici and Guihong ) were investigated. Results Compared with distilled water (DW) treatment, the total phenolic content (TPC) and total flavonoid content (TFC) in the pericarp of different lychee cultivars decreased after SGF digestion; especially, the TFC in “ Lizhiwang ” decreased by 41.5%. The TPC and TFC of lychee pericarp also decreased after SIF digestion. However, the TPC in “ Jizui ”, “ Guiwei ” and “ Yuhe ” increased. The SGF and SIF also had different effects on the FRAP and ABTS antioxidant activities of different lychee cultivars. The SGF digestion decreased the ABTS antioxidant capacity of lychee pericarp but enhanced the FRAP value of some lychee cultivars. However, the SIF digestion decreased the FRAP antioxidant activity of different lychee cultivar pericarps but enhanced the ABTS antioxidant capacity of lychee. The HPLC results showed that lychee pericarp had relatively high contents of procyanidin B2 and procyanidin A2. After SIF digestion, caffeic acid and isoquercitrin could not be detected in any of the lychee varieties. However, quercetin-3-rutinose-7-rhamnoside and isoquercitrin were increased after SGF digestion. Conclusions Lychee pericarp could be used as an inexpensive functional food ingredient.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of simulated digestion on the phenolic composition and antioxidant activity of different cultivars of lychee pericarp

Zeng

Dai

et al. 2019

BMC Chemistry

View full text Add to dashboard Cite

show abstract

“…Additionally, mangiferin, a polyphenol found in mango and papaya, has been found to decrease plasma lipids and inflammatory levels in mice with high fat diet-induced vascular injury through the PTEN/Akt/eNOS signaling pathway at 20 µM [64]. Moreover, in an in vivo myocardial ischemia rat model, 200 mg/kg lychee extract was found to exert myocardial protection through bcl-2/bax gene expression [65].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

View full text Add to dashboard Cite

Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

show abstract

“…In a previous study, the anti‐myocardial ischemic effect of resin‐purified ethanol extracts of litchi peep was evaluated in vivo using an acute myocardial ischemia rat model (Chen, Li, et al., 2017). Results showed a dose‐dependent (50, 100, and 200 mg/kg bw) protective effect of the extract on myocardial ischemia injury following a 5‐day oral administration.…”

Section: Pharmacological Phytochemical and Toxicological Aspects Of Litchi Fruit Seed And Peelmentioning

confidence: 99%

“…Results showed a dose‐dependent (50, 100, and 200 mg/kg bw) protective effect of the extract on myocardial ischemia injury following a 5‐day oral administration. The extract inhibited electrocardiogram depressions, reduced myocardial ischemia injury, improved cardiac enzyme indicators (creatinine kinase and lactate dehydrogenase) in serum, and increased the antioxidant status in serum and myocardial tissue (Chen, Li, et al., 2017). There was an increase in the activity of serum nitric oxide synthase, as well the myocardial tissue mRNA expression of eNOS and Bcl‐2 and a concomitant decrease in myocardial tissue mRNA expression of Bax (Chen, Li, et al., 2017), which suggests that the anti‐myocardial effect of the peel extract may be mediated by its endothelial protective, myocardial antioxidant, anti‐inflammatory, and anti‐apoptotic effects.…”

Section: Pharmacological Phytochemical and Toxicological Aspects Of Litchi Fruit Seed And Peelmentioning

confidence: 99%

“…The extract inhibited electrocardiogram depressions, reduced myocardial ischemia injury, improved cardiac enzyme indicators (creatinine kinase and lactate dehydrogenase) in serum, and increased the antioxidant status in serum and myocardial tissue (Chen, Li, et al., 2017). There was an increase in the activity of serum nitric oxide synthase, as well the myocardial tissue mRNA expression of eNOS and Bcl‐2 and a concomitant decrease in myocardial tissue mRNA expression of Bax (Chen, Li, et al., 2017), which suggests that the anti‐myocardial effect of the peel extract may be mediated by its endothelial protective, myocardial antioxidant, anti‐inflammatory, and anti‐apoptotic effects. The main components of the extract were procyanidin B2, (−)‐epicatechin, epicatechin‐(4β → 8,2β → O → 7)‐epicatechin‐(4β → 8)‐epicatechin, A‐type procyanidin trimer, B‐type procyanidin dimer, and procyanidin A2 (Chen, Li, et al., 2017), which may potentiate the antioxidant and anti‐myocardial effects of the peel extract.…”

Section: Pharmacological Phytochemical and Toxicological Aspects Of Litchi Fruit Seed And Peelmentioning

confidence: 99%

See 1 more Smart Citation

A review on the medicinal potential, toxicology, and phytochemistry of litchi fruit peel and seed

et al. 2021

View full text Add to dashboard Cite

The perception that many fruit wastes, particularly the peel, contain more phytochemicals than the edible portions has been largely supported by scientific evidence, making them potential sources of bioactive and therapeutic phytochemicals. The peel and seed of Litchi (Litchi chinensis Sonn.) contain bioactive principles and have been shown to exhibit antioxidative, antidiabetic, cancer preventive, anti‐obesogenic, and anti‐inflammatory properties. This review presents a critical analysis of previous and current perspectives on the medicinal, toxicological, and phytochemical profiles of litchi fruit peel and seed, thus providing an evidence‐based platform to explore their medicinal potential. A literature search was done on “PubMed,” “Google Scholar,” and “ScienceDirect.” Peer‐reviewed published data on the medicinal profiles of litchi fruit peel and seed were identified and critically analyzed. The fruit peel and seed improved glycemic control and insulin signaling and downregulated lipogenic and cholesterogenic processes. Their neuroprotective, hepatoprotective, and renal protective potentials were influenced by antioxidative and anti‐inflammatory actions. The anticancer effect was mediated by upregulated proapoptotic, proinflammatory, antiproliferative, and anti‐metastatic processes in cancer cells. Simple flavonols, sesquiterpenes, phenolic acids, jasmonates, and proathocyanidins are the possible bioactive principles influencing the medicinal effects. Appropriate toxicity studies are, however, still lacking. Litchi fruit wastes may be further studied as useful sources of therapeutic agents that may have medicinal relevance in oxidative, metabolic, vascular, and carcinogenic ailments. Practical applications Underutilized fruit wastes contribute to environmental pollution. Interestingly, these wastes contain phytochemicals that could be of medicinal relevance if their medicinal potentials are maximized. Litchi fruit is a widely consumed fruit with commercial value. Its peel and seeds contribute to fruit wastes. The review exposes the medicinal potential and bioactive principles and/or nutrients of the fruit's peel and seed while elucidating the underlying therapeutic mechanisms or modes of actions through which litchi peel and seed potentiate medicinal effects. Thus, the review provides an evidence‐based platform to explore the medicinal potential of underutilized wastes from litchi fruit. Additionally, the fruit peel and seed could be low‐cost residues that could afford ecofriendly opportunity if their medicinal potentials are properly maximized.

show abstract

Anti‐myocardial Ischemia Effect and Components of Litchi Pericarp Extracts

Cited by 13 publications

References 27 publications

Effects of simulated digestion on the phenolic composition and antioxidant activity of different cultivars of lychee pericarp

Effects of simulated digestion on the phenolic composition and antioxidant activity of different cultivars of lychee pericarp

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

A review on the medicinal potential, toxicology, and phytochemistry of litchi fruit peel and seed

Contact Info

Product

Resources

About