2012
DOI: 10.1590/s1517-83822012000100024
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Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata

Abstract: Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media.The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and… Show more

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Cited by 6 publications
(3 citation statements)
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“…The selective index value is used to distinguish toxicity that is due to plant extracts and toxicity in general (Adamu et al, 2014;Prince et al, 2012). Ficus sur showed the highest selectivity index of 3.363 in this study; which means it is three times more effective against M .tuberculosis as compared to human macrophage U937 cells.…”
Section: Cytotoxicity On U937 Cell Line and Selectivitymentioning
confidence: 68%
“…The selective index value is used to distinguish toxicity that is due to plant extracts and toxicity in general (Adamu et al, 2014;Prince et al, 2012). Ficus sur showed the highest selectivity index of 3.363 in this study; which means it is three times more effective against M .tuberculosis as compared to human macrophage U937 cells.…”
Section: Cytotoxicity On U937 Cell Line and Selectivitymentioning
confidence: 68%
“…An example of such bioactives can be found in the endophytic fungus Phomopsis stipata, isolated from Styrax camporum Pohl (Styracaceae), in whichits secondary metabolites showed some promising results, with significant in vitro antimycobacterial activity of 31.25 μg mL -1 (Prince et al 2012). In our continuous screening for biologically active secondary metabolites from plant endophytes, we investigated the ones produced by A. fumigatusisolated from Copaifera multijuga, an important Amazonian medicinal plant.…”
Section: Sandoval-montemayormentioning
confidence: 99%
“…The MIC values of MM and MIP, nonpathogenic microorganisms obtained from the studied fungal extracts closely related to the sensitivity of Mycobacterium tuberculosis in other studies on fungal extracts. De Prince et al (2012) and Gamboa-Angulo et al (2013) studied extracts from various fungal species for antimycobacterial activity and found them to possess anti-Mycobacterium tuberculosis activity. Jouda et al (2016) isolated various compounds produced by an endophytic fungus of Penicillium species harbored in Garcinia nobilis, and were found to be active against Mycobacterium smegmatis.…”
Section: Cytotoxic Activitiesmentioning
confidence: 99%