Anti-mycobacterial activity of thymine derivatives bearing boron clusters

Adamska, Anna; Rumijowska-Galewicz, Anna; Ruszczyńska, Anna; Studzińska, Mirosława; Jabłońska, Agnieszka; Paradowska, Edyta; Bulska, Ewa; Munier‐Lehmann, Hélène; Dziadek, Jarosław; Leśnikowski, Zbigniew J.; Olejniczak, Agnieszka B.

doi:10.1016/j.ejmech.2016.05.030

Cited by 27 publications

(16 citation statements)

References 48 publications

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“…The number of viable cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT; Sigma-Aldrich Co., St. Louis, MO, USA) assay, which is based on the reduction of yellowish MTT to insoluble and dark blue formazan by viable cells. Vero cells were subcultured in 96-well plates at a seeding density of 2 × 10 4 cells/well in EMEM supplemented with 10% FBS, L-glutamine, and antibiotics at 37 °C in a humidified 5% CO 2 environment [ 33 , 34 ]. Confluent monolayers of cells were treated with preparations of AuNPs I and AuNPs II at concentrations of 0.295 and 5.9 μg/mL, respectively (six wells for each concentration).…”

Section: Methodsmentioning

confidence: 99%

Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism

et al. 2021

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The antiviral activity of nonfunctionalized gold nanoparticles (AuNPs) against herpes simplex virus type-1 (HSV-1) in vitro was revealed in this study. We found that AuNPs are capable of reducing the cytopathic effect (CPE) of HSV-1 in Vero cells in a dose- and time-dependent manner when used in pretreatment mode. The demonstrated antiviral activity was within the nontoxic concentration range of AuNPs. Interestingly, we noted that nanoparticles with smaller sizes reduced the CPE of HSV-1 more effectively than larger ones. The observed phenomenon can be tentatively explained by the near-field action of nanoparticles at the virus envelope. These results show that AuNPs can be considered as potential candidates for the treatment of HSV-1 infections.

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Section: Methodsmentioning

confidence: 99%

Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism

et al. 2021

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“…they are able to form dihydrogen bonds with protic hydrogen atoms [ 136 ]. The hydride character of the hydrogen atoms also prevents the formation of conventional hydrogen bonds, resulting in these 3D compounds having various degrees of hydrophobicity [ 137 ]. Boron clusters are also unique in that they are abiotic and unfamiliar to most living organisms, potentially possessing greater stability and pharmacokinetic properties than organic molecules [ 138 ].…”

Section: Boron Medicinal Chemistrymentioning

confidence: 99%

The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry

2022

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In this review, the history of boron’s early use in drugs, and the history of the use of boron functional groups in medicinal chemistry applications are discussed. This includes diazaborines, boronic acids, benzoxaboroles, boron clusters, and carboranes. Furthermore, critical developments from these functional groups are highlighted along with recent developments, which exemplify potential prospects. Lastly, the application of boron in the form of a prodrug, softdrug, and as a nanocarrier are discussed to showcase boron’s emergence into new and exciting fields. Overall, we emphasize the evolution of organoboron therapeutic agents as privileged structures in medicinal chemistry and outline the impact that boron has had on drug discovery and development.

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“…The authors [ 74 ] synthesized thymine derivatives containing ortho -carborane, para -carborane, and nido -carborane clusters ( Fig. 18 ).…”

Section: Adamantane-type Derivatives With Anti-viral Activitymentioning

confidence: 99%

Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review)

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et al. 2022

Russ. J. Inorg. Chem.

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Data on compounds based on cage structures―boron clusters (polyhedral boron hydrides, carboranes, metallacarboranes) and compounds of the adamantane series, which possess physiological activity, have been generalized. The main emphasis is placed on the antiviral activity of the compounds. The mechanism of the possible action of the replication inhibitors of influenza A virus strains is considered, the molecular model of viroporin inhibitors is discussed. The proposed model consists of a cage hydrophobic core that performs the function of a membranotropic carrier (a boron cluster or adamantane fragment), into which physiologically active functional groups are introduced. The relationship between the structure of the cage compound with the introduced substitute and the biologically active properties of this molecular structure has been analyzed.

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Anti-mycobacterial activity of thymine derivatives bearing boron clusters

Cited by 27 publications

References 48 publications

Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism

Antiviral Effect of Nonfunctionalized Gold Nanoparticles against Herpes Simplex Virus Type-1 (HSV-1) and Possible Contribution of Near-Field Interaction Mechanism

The Boron Advantage: The Evolution and Diversification of Boron’s Applications in Medicinal Chemistry

Physiologically Active Compounds Based on Membranotropic Cage Carriers–Derivatives of Adamantane and Polyhedral Boron Clusters (Review)

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