Anti-MuSK myasthenia gravis presenting with purely ocular findings

Caress, James B.; Hunt, Carol; Batish, Sat Dev

doi:10.1016/j.ajo.2005.08.009

Cited by 15 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Disease severity and the antibody level are strongly correlated in patients with MuSK-MG (6). Although, in our case, the titer of serum anti-MuSK antibodies decreased under corticosteroid therapy, corresponding with an improvement in the patient's symptoms, the initial titer of anti-MuSK antibodies was extremely high, similar to that observed in the other ocular cases (8,9).…”

Section: Discussionsupporting

confidence: 84%

“…The patients usually progressed to generalized disease within two to three weeks; however, in some patients, fluctuating ptosis and diplopia remained the only complaint for up to 48 months before bulbar and/or neck weakness occurred. Only four cases of MuSK-MG involving ocular muscles have been reported (Table) (8)(9)(10)(11). Two of these involved observation for short terms of less than three to four months (8,9) and had the potential for generalization later.…”

Section: Discussionmentioning

confidence: 99%

“…Only four cases of MuSK-MG involving ocular muscles have been reported (Table) (8)(9)(10)(11). Two of these involved observation for short terms of less than three to four months (8,9) and had the potential for generalization later. The other two cases involved observation for longer terms (10, 11).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

An Ocular Form of Myasthenia Gravis with a High Titer of Anti-MuSK Antibodies during a Long-term Follow-up

et al. 2012

View full text Add to dashboard Cite

We herein report a case of ocular myasthenia gravis (MG) that was highly positive for anti-muscle-specific tyrosine kinase (MuSK) antibodies. The examined patient exhibited bilateral ptosis and lateral gaze palsy without any generalized symptoms and was diagnosed with ocular MG with anti-MuSK antibodies. She responded to treatment with prednisolone and immunosuppressants and experienced only ocular symptoms for four years and eight months after onset. Ocular MG with anti-MuSK antibodies lasting for a long term has rarely been described. Our findings suggest that it may be reasonable to test for the presence of anti-MuSK antibodies in patients who present with external ophthalmoplegia.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An Ocular Form of Myasthenia Gravis with a High Titer of Anti-MuSK Antibodies during a Long-term Follow-up

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Patients can show a severe predominantly faciobulbar weakness with dyspnea and nasal speech; dysphagia sometimes is so severe that it leads to an important weight loss. In some cases, only ocular muscles can be affected [18]. A significant association between bulbar/facial muscles weakness and muscular atrophy has been described in MuSK-positive patients [7], this could justify the selective and typical bulbar involvement.…”

Section: Clinical Featuresmentioning

confidence: 97%

Myasthenia Gravis with Anti-MuSK Antibodies: Clinical Features and Histopathological Changes

Angelini¹,

Martignago²,

Biscigli³

et al. 2012

A Look Into Myasthenia Gravis

View full text Add to dashboard Cite

“…About a three percent of patients with generalized MG have antibodies against MuSK, a neuromuscular junction protein that provides the clustering signal for AChR (Hoch et al 2001;Liyanage et al 2002;Evoli et al 2003;Zhou et al 2004). Rare cases of pure OM in association with MuSK antibodies are described (Caress et al 2005 …”

Section: Serum Autoantibody Evaluationmentioning

confidence: 99%