Anti-Müllerian Hormone Type II Receptor Expression in Endometrial Cancer Tissue

Gowkielewicz, Marek; Lipka, Aleksandra; Majewska, Marta; Piotrowska, Aleksandra; Szadurska-Noga, Marta; Nowakowski, Jacek J.; Wiszpolska, Marta; Dzięgiel, Piotr; Waśniewski, Tomasz; Majewski, Mariusz; Jóźwik, Marcin

doi:10.3390/cells9102312

Cited by 5 publications

(4 citation statements)

References 40 publications

(75 reference statements)

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“…We further investigated the expression of AMH. In human medicine, AMH is commonly expressed in ovarian granulosa cells and endometrial cancer [6,7]. Immunolabelling of glandular and luminal epithelia is reported in a healthy human endometrium, with additional stromal positivity depending on the uterine functional phase [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…This syndrome is characterized by Müllerian derivatives in the normally masculinized XY genotype. Canine PMDS and the associated clinical signs have been largely reported in miniature schnauzer [6,7]. A single homozygous cytosine substitution to thymidine in exon 3 at nucleotides 241 of the MISRII gene was identified as the causative genetic defect in this breed [8].…”

Section: Introductionmentioning

confidence: 95%

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Clinical and Histological Findings of Male Uterus (Uterus Masculinus) in Three Dogs (2014–2018)

Tura

Ballotta

Cunto

et al. 2023

Animals

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Data from three cases of uterus masculinus were retrieved from 2014 to 2018. Two out of three cases presented clinical signs compatible with systemic infection, as observed in bitches with pyometra. Ultrasound examination revealed a tubular fluid-filled structure with a thin irregular wall located cranially to the prostate and in continuity with the cranial part of the gland. In two cases, two other tubular fluid-filled structures were visualized in the caudal part of the abdominal cavity, ventrally to the prostate gland and urinary bladder. After surgical removal of these, histological examination revealed the presence of a uterine structure morphologically similar to the female counterpart. Various types of epithelial cell lining were found, including simple columnar, simple stratified and squamous epithelium associated with glands in the underlying stroma. Immunohistochemistry to anti-Müllerian hormone (AMH) produced a positive result on glands, while multifocal expression was found in the lining epithelium. AMH seems involved in the pathogenesis of uterus masculinus, but its role is not fully understood. Thorough clinical and ultrasonographical examinations, followed by a histological confirmation, are necessary to properly diagnose uterus masculinus in dogs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Clinical and Histological Findings of Male Uterus (Uterus Masculinus) in Three Dogs (2014–2018)

Tura

Ballotta

Cunto

et al. 2023

Animals

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“…Результаты данного исследования могут свидетельствовать о защитных свой ствах АМГ в отношении многих видов рака, в связи с чем его следует рассмотреть как потенциальный маркер прогноза и препарат для таргетной терапии [19]. Более позднее исследование продемонстрировало аналогичные результаты [20]. В работе S.M.…”

Section: репродуктивное здоровье и вртunclassified

The role of anti-Mullerian hormone in the context of modern pathogenetic approaches to the treatment of endometriosis (literature review)

Buralkina,

Chekeneva,

Pavlovich

et al. 2023

Medicinskij sovet

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Anti-Mullerian hormone (AMH) is well known as one of the key factors in reproductive development and the formation of sexual characteristics in the embryonic period in both sexes. In women, AMH is produced by granulosa cells of the preantral and early antral follicles of the ovaries and is a key biochemical marker of ovarian reserve. Recently, the role of AMH and its transmembrane receptor AMHRII as possible pathogenetic links in a number of gynecological diseases has been actively studied. The ability of AMH to cause regression of the Müllerian duct in male embryos suggests its inhibitory role for a number of benign and malignant gynecological tumors, as well as endometriosis. In this connection, active scientific research in this direction is currently underway. A number of studies have shown that AMH causes apoptosis of human endometrial stromal cells and endometriosis cells in vitro, and is also involved in the development of autophagy processes in endometriosis. The above studies demonstrate the important role of AMH in cell apoptosis in endometriosis, and indicate its therapeutic potential for a wide range of gynecological diseases. It is important to note that AMH, as a representativemember of the TGF-β superfamily, has high affinity and specificity for the AMHRII receptor, which. This fact makes further study of the function of AMH and AMHRII relevant both for assessing their effectinfluence on the processes of folliculogenesis, and reproductive aging processes, and for developing new targeting targeted therapy strategies therapy for a wide range of gynecological diseases, including endometriosis.

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“…Tamoxifen also has an impact on a higher incidence of benign pathologies of the endometrium, such as endometrial polyps [5]. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women after breast cancer and bronchial cancer, in some developed countries, the rationale behind the uterine cancer screening protocol in women on SERM therapy is being widely discussed [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem

Jabłoński¹,

Kurek²,

Żukowski³

et al. 2020

JCM

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Tamoxifen is a commonly used selective estrogen receptor modulator applied in the treatment for breast cancer. However, in the endometrium, Tamoxifen stimulates tissue growth, cellular transformation, the migration of the cells, and metastatic potential in endometrial cancer. Considering that uterine cancer is the most common neoplasm of the reproductive tract and the third most common neoplastic disease in women, the aim of this study was to investigate if applying elastography in examining the endometrium was beneficial for uterine cancer screening protocols in women on selective estrogen receptor modulator therapy. This study was based on the execution of a classic assessment of the endometrium that included the evaluation of the following: echogenicity, central endometrial stripe, presence of fluid in the uterine lumen, myometrium–endometrium interface, intensity of vascularization and vascular pattern. An ultrasound presentation was then processed and analyzed with elastography. The values of the elastography parameters demonstrated good consistency for the measurement of the softest endometrial layer thickness in elastography. A strong positive correlation (R = 0.56) was demonstrated between the endometrial thickness, as determined by ultrasound examination, and the softest endometrial layer in elastography (p < 0.001). The research showed that the elastography measurements of the width of the softest endometrium layer, based on a population of women taking Tamoxifen, appeared to be a promising option for endometrial cancer screening.

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Anti-Müllerian Hormone Type II Receptor Expression in Endometrial Cancer Tissue

Cited by 5 publications

References 40 publications

Clinical and Histological Findings of Male Uterus (Uterus Masculinus) in Three Dogs (2014–2018)

Clinical and Histological Findings of Male Uterus (Uterus Masculinus) in Three Dogs (2014–2018)

The role of anti-Mullerian hormone in the context of modern pathogenetic approaches to the treatment of endometriosis (literature review)

Elastography of Endometrium in Women Taking Tamoxifen: A New Approach to an Old Diagnostic Problem

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