Anti-Müllerian Hormone: The Jost Factor

Josso, Nathalie; Rl, Cate; Jy, Picard; Vigier, B.; N, di Clemente; Wilson, Cheryl A.; Imbeaud, Sandrine; Rb, Pepinsky; Guerrier, Daniel; Boussin, L

doi:10.1016/b978-0-12-571148-7.50005-1

Cited by 181 publications

(115 citation statements)

References 123 publications

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“…During male sexual development, the Müllerian ducts are eliminated by the actions of the MIS signaling pathway (Josso et al, 1993). Regression of the Müllerian duct system visualized by the Lim1 tlz reporter was first observed at E14.5 Development 131 (3) Research article Over the next 2 days of embryonic development, the Müllerian duct system in the male fetus is eliminated.…”

Section: Visualization Of Müllerian Duct Development By Lim1 Tlzmentioning

confidence: 99%

Requirement ofLim1for female reproductive tract development

et al. 2004

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Lim1 encodes a LIM-class homeodomain transcription factor that is essential for head and kidney development. In the developing urogenital system, Lim1 expression has been documented in the Wolffian(mesonephric) duct, the mesonephros, metanephros and fetal gonads. Using, a Lim1 lacZ knock-in allele in mice, we identified a previously unreported urogenital tissue for Lim1 expression, the epithelium of the developing Müllerian duct that gives rise to the oviduct, uterus and upper region of the vagina of the female reproductive tract. Lim1expression in the Müllerian duct is dynamic, corresponding to its formation and differentiation in females and regression in males. Although female Lim1-null neonates had ovaries they lacked a uterus and oviducts. A novel female mouse chimera assay was developed and revealed that Lim1 is required cell autonomously for Müllerian duct epithelium formation. These studies demonstrate an essential role for Lim1 in female reproductive tract development.

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Section: Visualization Of Müllerian Duct Development By Lim1 Tlzmentioning

confidence: 99%

Requirement ofLim1for female reproductive tract development

et al. 2004

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“…In males, MDs regress due to the sexual dimorphic expression of the antiMüllerian hormone (AMH), also known as Müllerian-inhibiting substance (MIS), a member of the transforming growth factor-β (TGF-β) family, secreted by the Sertoli cells of the foetal testis (Josso et al 1993). In addition, testosterone production by Leydig cells, allows androgen-dependant growth and differentiation of Wolffian ducts into epididymides, vas deferens and seminal vesicles (Hannema and Hughes 2007).…”

Section: Differentiation Of the Müllerian Ductmentioning

confidence: 99%

The developing female genital tract: from genetics to epigenetics

Massé¹,

Watrin²,

Laurent³

et al. 2009

Int. J. Dev. Biol.

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115

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The mammalian female reproductive tract develops from the Müllerian ducts which differentiate, in a cranial to caudal direction, into oviducts, uterine horns, cervix and the anterior vagina. The developmental processes taking place during this organogenesis are notably under the control of steroid hormones, such as members of the Wnt and Hox families, which regulate key developmental genes. At later stages, steroid hormones also participate in the development of the female genital tract. Chemical compounds homologous to steroids can thus act as agonists or antagonists in fetuses exposed to them. These so-called endocrine disruptors are nowadays found in increasing amounts in the environment and may therefore have a particular impact on such developing organs. Epidemiological studies have revealed that endocrine disruptors have had drastic effects on female health and fertility during the last decades. Furthermore, these adverse effects might be transmitted to subsequent generations through epigenetic modifications. Given the potential hazard of inherited epigenetic marks altering reproduction and/or human health, such molecular mechanisms must be urgently investigated. This review aims to summarize the cellular and molecular mechanisms involved in female genital tract development, to highlight key genes involved in this process and to present epigenetic mechanisms triggered by endocrine disruptors and their consequences in regard to female reproductive tract development. KEY WORDS: genital tract, Hox, Wnt, genetics, epigenetics Development of the urogenital system Relation between urinary and genital tractsMammalian genital tract development is closely related to the urinary system embryogenesis. This relation is ancient in evolution and phylogenetically well conserved. In simple organisms like annelids, they both consist in metamerized nephritic tubules composed of a ciliated funnel oriented towards the coelomic cavity and connected to a vascularised duct that opens to the exterior. This system is involved in metabolites and mature genital cells excretion. In higher vertebrates, the urogenital apparatus comprises the kidneys, gonads, urinary and reproductive ducts. The urinary tract embryonic formation is the result of a three steps process that gives rise to three successive structures emerging rostrocaudally in the intermediate mesoderm. Nephrotomes first develop in the cervical part of the embryo; they consist in a ciliated funnel emerging in the coelomic cavity and in a nephritic tubule Int. J. Dev. Biol. 53: 411-424 (2009) doi: 10.1387/ijdb.082680jm connected to a common excretory duct (the Wolffian duct, WD). At this stage, they form a primitive kidney called pronephros which is not functional. This transitory organ can only be observed in vertebrate embryos and agnathe larvae (Saxen and Sariola 1987;Bouchard et al. 2002). Then, while the pronephros is regressing, the mesonephros develops posteriorly, allowing the WD to grow in the same direction. This intermediary kidney, comprising a Bowman ...

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“…It is named after its role in male sexual differentiation because it was originally identified in rabbit male fetuses as a testicular factor distinct from testosterone that caused regression of the Müllerian ducts (Jost 1947) and was subsequently found to be produced by Sertoli cells in males (Josso et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian Hormone (AMH) and fertility management in agricultural species

Mossa¹,

Jimenez-Krassel²,

Scheetz³

et al. 2017

Reproduction

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A reliable, easy to assess marker for fertility in agricultural species would be highly desirable and Anti-Müllerian Hormone (AMH) is a promising candidate. This review summarizes recent findings concerning AMH and its role in fertility management, mainly in cattle. It focuses on (1) alterations in circulating AMH concentrations from birth to puberty and during estrous cycles; (2) correlation of circulating AMH concentrations with ovarian follicle numbers and ovarian reserve; (3) factors that impact circulating AMH concentrations; (4) use of AMH as a predictor of fertility. Circulating AMH concentrations can be easily and reliably measured with a single blood sample in adult cattle because AMH varies minimally during the estrous cycle and is repeatable across multiple cycles. Circulating AMH concentrations are positively associated with several measures of fertility. Dairy heifers with low compared with higher AMH concentrations subsequently had lower pregnancy rates, higher probability of being culled after birth of their first calf and shorter herd longevity. Also, AMH is predictive of response to superovulation in cattle and sheep. Several factors contribute to the variability in AMH concentrations among individuals; for example, beef cattle have higher AMH than dairy cattle. Nutritional imbalances, disease and endocrine disruptors during fetal life may negatively program the size of the ovarian reserve and consequently serum AMH concentrations and potential fertility in adulthood. We conclude that AMH may be a predictor of fertility and herd longevity in cattle, whereas in sheep and other farm species, the potential association between AMH and reproductive performance remains largely unexplored. Free Italian abstract: An Italian translation of this abstract is freely available at http://www.reproduction-online.org/content/154/1/ R1/suppl/DC1. Reproduction (2017) 154 R1-R11

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Anti-Müllerian Hormone: The Jost Factor

Cited by 181 publications

References 123 publications

Requirement ofLim1for female reproductive tract development

Requirement ofLim1for female reproductive tract development

The developing female genital tract: from genetics to epigenetics

Anti-Müllerian Hormone (AMH) and fertility management in agricultural species

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