Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells

Pellatt, Laura; Rice, Suman; Dilaver, Nafi; Heshri, Amira; Galea, R.; Brincat, Mark; Brown, Kristy A.; Simpson, Evan R.; Mason, Helen

doi:10.1016/j.fertnstert.2011.08.015

Cited by 220 publications

(157 citation statements)

References 32 publications

Supporting

Mentioning

140

Contrasting

Unclassified

Order By: Relevance

“…Serum AMH reflects the secretion of AMH only from the follicles that are vascularised [8]. AMH regulates follicle growth by the inhibition of their sensitivity to follicle-stimulating hormone (FSH) [9]. In the physiological menstrual cycle, when the follicle matures and reaches a diameter of around 6 mm, it enters the FSH-dependent growth phase, resulting in follicle selection and ovulation.…”

Section: Amh-physiologymentioning

confidence: 99%

“…Stężenie AMH w surowicy krwi jest odzwierciedleniem ilości AMH produkowanego w pę-cherzykach, które są bogato unaczynione [8]. Hormon anty-müllerowski reguluje wzrost pęcherzyków jajnikowych, mając wpływ na rekrutację wzrostu z puli pęcherzyków zawiązkowych i hamując ich wrażliwość na hormon folikulotropowy (FSH) [9]. W cyklu fizjologicznym wzrost stężenia FSH w pierwszych dniach cyklu rekrutuje pęcherzyki antralne do wzrostu w fazie zależnej od gonadotropin.…”

Section: Amh -Fizjologiaunclassified

See 1 more Smart Citation

Hormon anty-müllerowski i zespół policystycznych jajników

Łebkowska

Kowalska

2015

Endokrynologia Polska

View full text Add to dashboard Cite

Anti-Müllerian hormone (AMH) is a glycoprotein, a member of the transforming growth factor β family, reflecting the number of ovarian antral follicles. Polycystic ovary syndrome (PCOS) is a common endocrinopathy predisposing to infertility, and metabolic and cardiovascular complications. In our review, we discuss the role of AMH in PCOS pathophysiology and its clinical applications according to the published studies. Improvement of AMH assay validity will allow the clinical utility of this valuable biomarker to be widened.

show abstract

Section: Amh-physiologymentioning

confidence: 99%

Section: Amh -Fizjologiaunclassified

Hormon anty-müllerowski i zespół policystycznych jajników

Łebkowska

Kowalska

2015

Endokrynologia Polska

View full text Add to dashboard Cite

show abstract

“…Он по-давляет инициацию роста примордиальных фолликулов на ранних этапах фолликулогене-за. Известно, что АМГ ингибирует каталити-ческую активность ФСГ-зависимой ароматазы через репрессию гена CYP19 в культурах чело-веческих клеток гранулезы [18,19]. В фолли-кулярной жидкости малых антральных фолли-кулов яичника человека имеется значительная отрицательная корреляция между уровнями АМГ и экспрессией гена CYP19.…”

unclassified

“…Так, введение АМГ в культуру клеток гранулезы приводит к значительному сниже-нию производства цАМФ, что впоследствии может снизить транскрипцию гена CYP19 [20]. Также в клетках гранулезы человека АМГ по-нижает экспрессию мРНК ФСГ-рецептора [19], что выражается снижением чувствительности преантральных фолликулов к ФСГ. Добавление АМГ к культивированным фолликулам мышей с нокаутированным геном АМГ приводит к за-медлению роста фолликулов в присутствии ФСГ, что подтверждает ингибирующий эффект АМГ на ФСГ-зависимую пролиферацию клеток гранулезы [21].…”

unclassified

“…Добавление АМГ к культивированным фолликулам мышей с нокаутированным геном АМГ приводит к за-медлению роста фолликулов в присутствии ФСГ, что подтверждает ингибирующий эффект АМГ на ФСГ-зависимую пролиферацию клеток гранулезы [21]. Было также установлено, что снижение ароматазной активности под воздей-ствием АМГ повышает синтез андрогенов [19].…”

unclassified

See 1 more Smart Citation

Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Yakovlev

Павлович

2017

Z.akus.zen.bolezn

View full text Add to dashboard Cite

The Aim of the study was to assess modern considerations about the role of aromatase P450 enzyme in female reproductive system and the effect of its activity on the protocols of in vitro fertilization (IVF). Materials: foreign and Russian literature data from 1978 to 2016. Methods:review and synthesis of publications has been performed. Conclusions: Ovarian aromatase is the key steroidogenesis enzyme of the female reproductive system. Its activity depends on many factors, both of intraovarian and extragonadal origin. The ovarian follicular response and oocyte quality in IVF may depend on aromatase activity.

show abstract

Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age

Steiner

Pritchard

Stanczyk

et al. 2017

JAMA

298

181

View full text Add to dashboard Cite

Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential or “fertility tests.” Objective To determine the extent to which biomarkers of ovarian reserve are associated with reproductive potential among late-reproductive age women. Design, Setting, and Participants Prospective, time-to-pregnancy cohort study (2008-March 2016) of women (N=981) 30–44 years of age without a history of infertility who had been trying to conceive for 3 months or less were recruited from the community in the Raleigh-Durham area. Exposures Early follicular phase serum level of antimüllerian hormone (AMH), follicle stimulating hormone (FSH), and inhibin B, and urinary level of FSH. Main Outcomes and Measures The primary outcomes were the cumulative probability of conception by 6 and 12 cycles of attempt and relative fecundability, the probability of conception in a given menstrual cycle. Conception was defined as a positive pregnancy test. Results 750 women (33.3[3.2] years of age; 77% white; 36% overweight or obese), provided a blood and urine sample and were included in the analysis. After adjusting for age, body mass index, race, current smoking status and recent hormonal contraceptive use, women with low AMH values (<0.7ng/ml, N=84) did not have a significantly different predicted probability of conceiving by 6 cycles of attempt (65%; 95% Confidence Interval (CI): 50–75%) compared to women (N=579) with normal values (62%; 95% CI: 57–66%) nor by 12 cycles of attempt (84%; 95% CI: 70–91% versus 75%; 95% CI: 70–79%, respectively). Women with high serum FSH values (>10mIU/ml, N=83) did not have a significantly different predicted probability of conceiving after 6 cycles of attempt (63%; 95% CI: 50–73%) compared to women (N=654) with normal values (62%; 95% CI: 57–66%) nor after 12 cycles of attempt (82%; 95% CI: 70–89 versus 75%; 95% CI: 70–78%). Women with high urinary FSH values (>11.5mIU/mgcr, N=69) did not have a significantly different predicted probability of conceiving after 6 cycles of attempt (61%; 95% CI: 46–74%) compared to women (N=660) with normal values (62%; 95% CI: 58–66%) nor after 12 cycles of attempt (70%; 95% CI: 54–80% versus 76%; 95% CI: 72–80%). Inhibin b levels (N=737) were not associated with the probability of conceiving in a given cycle (Hazard Ratio [per 1pg/ml increase] = 0.999; 95% CI: 0.997–1.001). Conclusions Among women age 30–44 years of age without a history of infertility, who had been trying to conceive for 3 months or less, biomarkers indicating diminished ovarian reserve, compared to normal ovarian reserve, were not associated with reduced fertility. These findings do not support the use of urinary or blood FSH tests or AMH levels to assess natural fertility for women with these characteristics.

show abstract

Anti-Müllerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells

Cited by 220 publications

References 32 publications

Hormon anty-müllerowski i zespół policystycznych jajników

Hormon anty-müllerowski i zespół policystycznych jajników

Aromatase P450 activity in the natural menstrual cycle and during controlled ovarian stimulation

Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age

Contact Info

Product

Resources

About