Anti-Müllerian Hormone Levels in Peripubertal Daughters of Women with Polycystic Ovary Syndrome

Crisosto, Nicolás; Codner, Ethel; Maliqueo, Manuel; Echiburú, Bárbara; Sánchez, Francisco Javier Sierro; Cassorla, Fernando; Sir-Petermann, Teresa

doi:10.1210/jc.2007-0267

Cited by 118 publications

(76 citation statements)

References 30 publications

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“…In our subjects, AMH was not correlated with basal insulin or HOMA-IR levels in group 1, group 2 or group 3. We believe this supports that 5 should also be studied.…”

Section: Discussionsupporting

confidence: 73%

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Is anti-Mullerian hormone an indicator of potential polycystic ovary syndrome in prepubertal girls with simple obesity?

et al. 2016

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“…In our subjects, AMH was not correlated with basal insulin or HOMA-IR levels in group 1, group 2 or group 3. We believe this supports that 5 should also be studied.…”

Section: Discussionsupporting

confidence: 73%

“…Women with PCOS were shown to have higher AMH levels compared to healthy women. Different studies have also reported higher AMH levels in prepubertal and peripubertal daughters of women with PCOS [4][5][6] . These reports suggest that changes in AMH production associated with PCOS may be observed even during the prepubertal period.…”

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confidence: 96%

Is anti-Mullerian hormone an indicator of potential polycystic ovary syndrome in prepubertal girls with simple obesity?

et al. 2016

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“…The sensitivity of newer ELISAs has improved (0.006 ng/ml) and a more recent study has reported appreciable levels of AMH in the serum of infants and young girls (Sir-Petermann et al 2006). However, these same investigators measured higher levels in peripubertal girls (Crisosto et al 2007), which suggest that serum AMH is relatively low in females before puberty. Thus, lower serum AMH concentration in 10-week-old SD hamsters may simply reflect their prepubertal state, but still, the underlying etiology remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Photoperiod-dependent modulation of anti-Müllerian hormone in female Siberian hamsters, Phodopus sungorus

Kabithe

Place²

2008

Reproduction

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Fertility and fecundity decline with advancing age in female mammals, but reproductive aging was decelerated in Siberian hamsters (Phodopus sungorus) raised in a short-day (SD) photoperiod. Litter success was significantly improved in older hamsters when reared in SD and the number of primordial follicles was twice that of females held in long days (LD). Because anti-Mü llerian hormone (AMH) appears to inhibit the recruitment of primordial follicles in mice, we sought to determine whether the expression patterns of AMH differ in the ovaries and serum of hamsters raised in SD versus LD. Ovaries of SD female hamsters are characterized by a paucity of follicular development beyond the secondary stage and are endowed with an abundance of large eosinophilic cells, which may derive from granulosa cells of oocyte-depleted follicles. In ovaries from 10-week-old SD hamsters, we found that the so-called 'hypertrophied granulosa cells' were immunoreactive for AMH, as were granulosa cells within healthy-appearing primary and secondary follicles. Conversely, ovaries from age-matched LD animals lack the highly eosinophilic cells present in SD ovaries. Therefore, AMH staining in LD was limited to primary and secondary follicles that are comparable in number to those found in SD ovaries. The substantially greater AMH expression in SD ovaries probably reflects the abundance of hypertrophied granulosa cells in SD ovaries and their relative absence in LD ovaries. The modulation of ovarian AMH by day length is a strong mechanistic candidate for the preservation of primordial follicles in female hamsters raised in a SD photoperiod. Reproduction (2008) 135 335-342

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“…The elevated androgen levels in women with PCOS are the cause of high levels of AMH [43]. Another study notes that the AMH levels of the prepubertal daughters of women with PCOS were higher than those in in the prepubertal daughters of women without PCOS [44]. This indicates that these children have a high risk of becoming PCOS in the future.…”

Section: Discussionmentioning

confidence: 99%

Anti-Müllerian Hormone (AMH) in Adults with Polycystic Ovary Syndrome and Pregnants

Sarıyıldız¹

2016

Eu Clin Anal Med

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ÖzetAmaç: Çalışmada puberta öncesi ve sonrası sağlıklı kız çocukları; over kistli yetişkinler ile hamilelerde anti-Müllerian hormonu AMH ve bazı biyokimyasal parametrelerin karşılaştırılmaları yoluyla değişimin saptanması amaç-landı. Gereç ve Yöntem: Bu çalışma Dr. Faruk Sükan Doğum ve Çocuk Hastanesinin polikliniklerine başvuran ve herhangi bir metabolik hastalığı olmayan dört grupta yer alan toplam100 katılımcı üzerinde gerçekleştirildi. Çalış-maya 7-12 yaş arası prepubertal dönemdeki kız çocuklarından (n=25), 18-24 yaş arası over kist sendromlu (n=25), 18-25 yaş arası hamileliğin 1.trimesterindeki kadınlardan (n=25) ve 18-24 yaş arası (n=25) sağlıklı bireyler kontrol grubu olarak alındı. Bulgular: Prepubertal dönemde (7-12 yaş arası) 25 kız çocuğu ile kontrol grubu(18-24 yaş arası) 25 kız çocuğu AMH değerle-ri sırasıyla 3,62 pg/dl; 3,60 pg/dl olarak bulundu (p═0,7636). Çalışmada over kist sendromlu grubun (18-24 yaş arası) AMH seviyesi 4,11 pg/dL (p═0,8690) olarak bulundu. Tartışma: AMH'nin klinik çalışmalarda over rezervinin tespit edilmesinde kullanılması infertilite tedavisinin ve yardımcı üreme tekniklerinin başarısını önceden tahmin etme ve PKOS'un teşhisi anlamında avantajlar sağlamaktadır. Anahtar KelimelerAnti-Müllerian Hormon; Over Kisti; Hamilelik; Fertilite AbstractAim: The aim of the study was to investigate serum anti-Müllerian hormone (AMH) and various biochemical parameter levels in healthy females before and after puberta, adults with polycystic ovary syndrome and pregnant women. Material and Method: The present study was performed on 100 female volunteers in four groups who applied to the polyclinic in Dr. Faruk Sukan maternal and children hospital and who had no metabolic syndrome.The groups were classified as: group 1: 7-12 years of age, prepubertal period (n=25); group 2: 18-25 years of age, pregnant females in the first trimester (n=25); group 3: 18-24 years of age, suffering from ovarian cysts (n=25); group 4: 18-24 years of age postpubertal as a control group (n=25). Results: The levels of AMH were found in prepubertal females (age 7-12) and the control group (age 18-24) as 3.62 pg/dl and 3.60 pg/dl, respectively (p=0.7636). The levels of AMH were 4.11 pg/dl (p=0.8690) in the women suffering from polycystic ovary syndrome. Discussion: The use of AMH in the measurement of ovarian reserve in clinical trials provides an advantage in early diagnosis of infertility and polycystic ovary syndrome (PCOS).

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Anti-Müllerian Hormone Levels in Peripubertal Daughters of Women with Polycystic Ovary Syndrome

Abstract: AMH concentrations are increased in peripubertal PCOSd. These findings, along with the results of our previous study, suggest that PCOSd appear to show an increased follicular mass that is established during early development, and persists during puberty.

Cited by 118 publications

References 30 publications

Is anti-Mullerian hormone an indicator of potential polycystic ovary syndrome in prepubertal girls with simple obesity?

Is anti-Mullerian hormone an indicator of potential polycystic ovary syndrome in prepubertal girls with simple obesity?

Photoperiod-dependent modulation of anti-Müllerian hormone in female Siberian hamsters, Phodopus sungorus

Anti-Müllerian Hormone (AMH) in Adults with Polycystic Ovary Syndrome and Pregnants

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