Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome

Diamanti-Kandarakis, Evanthia; Piouka, Athanasia; Livadas, Sarantis; Piperi, Christina; Katsikis, Ilias; Papavassiliou, Athanasios G.; Panidis, D

doi:10.1530/eje-08-0510

Cited by 61 publications

(50 citation statements)

References 50 publications

(53 reference statements)

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“…75 More relevant is the finding of significant positive correlation between AMH levels and AGEs in normal weight women with PCOS. 76 In this study, AMH and AGEs concentrations were evaluated in women with ovulatory PCOS, in women with anovulatory PCOS, in anovulatory women without the syndrome and in healthy controls. Their levels were significantly higher in the group of anovulatory PCOS as compared to the other study groups.…”

Section: Amh In Polycystic Ovary Syndromementioning

confidence: 99%

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

Karkanaki¹,

Vosnakis²,

Panidis³

2011

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Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily. Over the last decade, a large number of studies examining the multiple roles of AMH have been published. AMH levels accurately reflect the ovarian follicular reserve and could, therefore, be considered as an extremely sensitive marker of ovarian aging and a valuable tool in the diagnosis and the recognition of recurrence of granulosa cell tumors. Furthermore, AMH evaluation is of clinical importance in predicting the success of in vitro fertilization (IVF). Additionally, AMH could be a surrogate diagnostic marker of polycystic ovary syndrome in cases in which ultrasonographic examination is not possible. This article is a review of the clinical usefulness of AMH evaluation in the fields of gynecological endocrinology, menopause, gynecological oncology and assisted reproduction. Special reference is made to the possible implications of AMH in the pathogenesis of polycystic ovary syndrome and the relationship between AMH and obesity.

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Section: Amh In Polycystic Ovary Syndromementioning

confidence: 99%

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

Karkanaki¹,

Vosnakis²,

Panidis³

2011

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“…Additionally, it has been suggested that circulating AMH level is a marker of PCOS symptom severity [8]. Higher plasma AMH levels in amenorrheic than in oligomenorrheic women, independently of the degree of hyperandrogenism, were shown in some studies [9,10]. This indicates that AMH may play some role in PCOS-related anovulation.…”

Section: Introductionmentioning

confidence: 99%

Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome

Olszanecka-Glinianowicz¹,

Zachurzok

Drosdzol–Cop

et al. 2016

Horm Res Paediatr

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Background/Aims: The aim of this study was to assess whether circulating anti-Müllerian hormone (AMH) levels in daughters of women with polycystic ovary syndrome (PCOSd) correspond with clinical and biochemical features of hyperandrogenism, polycystic ovary morphology and menstrual cycle disturbances. Methods: Menstrual cycle disturbances, hirsutism, acne and ultrasonographic ovarian morphology were assessed in 75 girls aged 13-18 years (35 PCOSd and 40 daughters of healthy women). Serum gonadotropins, androgens, sex hormone-binding globulin and plasma AMH were measured in a fasting state, and the free androgen index was calculated. Results: A significant correlation between the AMH level and mean ovary volume was found (r = 0.36; p < 0.01). AMH levels were not related to hirsutism, acne and polycystic ovary morphology. Significantly higher AMH levels were found only in PCOSd with irregular menstruation or secondary amenorrhea. The results of logistic regression analysis showed that in that group for each 1-ng/ml increase in the AMH level, the odds ratio of the PCOS occurrence in the future was increased 1.27 times (95% CI: 1.09-1.47; p < 0.01). Conclusions: A higher AMH level in PCOSd is associated with menstrual cycle disturbances and larger ovarian volume but not with clinical and biochemical features of hyperandrogenism. Thus, the risk for PCOS development among genetically predisposed girls may be related to increased AMH levels.

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“…11,19 Our scientific interest is focused on the role of AGEs in relation to PCOS pathology as a distinct finding associated with hyperandrogenemia and insulin resistance. 11,19 With their prolonged half-life and ability to act as signaling molecules, AGEs may gradually accumulate in the ovary. In-vivo studies have shown that rodents fed with high AGE diet exhibit increased circulating AGE levels that are correlated with increased deposition of these agents in ovarian granulose cell layer.…”

Section: Discussionmentioning

confidence: 99%

Advanced glycation end-products and insulin signaling in granulosa cells

Diamanti-Kandarakis

Chatzigeorgiou

Papageorgiou

et al. 2015

Exp Biol Med (Maywood)

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Advanced glycation end-products (AGEs) may interfere with insulin intracellular signaling and glucose transport in human granulosa cells, potentially affecting ovarian function, follicular growth, linked with diminished fertility. The potential interaction of AGEs with insulin signaling pathways and glucose transport was investigated in human granulosa KGN cells. KGN cells were cultured with variable concentrations of human glycated albumin (HGA, 50-200 mg/mL) or insulin (100 ng/mL). Combined treatments of KGN cells with insulin (100 ng/mL) and HGA (200 mg/mL) were also performed. p-AKT levels and glucose transporter type 4 (Glut-4) translocation analysis were performed by Western blot. Phosphatidylinositol-3-kinase (PI3K)-specific signaling was checked by using the PI3K-inhibitor, LY294002. p-AKT levels were significantly increased following insulin treatment compared to basal levels or HGA exposure. This insulin-mediated AKT-phosphorylation was PI3K-specific and it was inhibited after combined treatment of insulin and HGA. Furthermore, Glut-4 translocation from the cytoplasm to the membrane compartments of KGN cells was remarkably reduced after the combined treatment of insulin and HGA. The present findings support that AGEs interfere with insulin signaling in granulosa cells and prevent Glut-4 membrane translocation suggesting that intra ovarian AGEs accumulation, from endogenous or exogenous sources, may contribute to the pathophysiology of states characterized with anovulation and insulin resistance such as polycystic ovary syndrome.

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Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome

Cited by 61 publications

References 50 publications

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

Circulating Anti-Müllerian Hormone Levels in Daughters of Women with and without Polycystic Ovary Syndrome

Advanced glycation end-products and insulin signaling in granulosa cells

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