Anti-Müllerian hormone in men with normal and reduced sperm concentration and men with maldescended testes

Tüttelmann, Frank; Dykstra, Nina; Themmen, Axel P. N.; Visser, Jenny A.; Nieschlag, Eberhard; Simoni, Manuela

doi:10.1016/j.fertnstert.2008.02.118

Cited by 74 publications

(63 citation statements)

References 40 publications

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“…We did not have data on IGF-1 levels in our patients but there is no reason to expect that IGF-1 levels changed in our subjects during this study. It was shown recently that plasma AMH levels are not significantly affected by impaired spermatogenesis per se and are not correlated with FSH [5]. We noted that 3 men in our study with raised FSH levels (9.2, 10.2 and 18.3 U/L) had normal AMH levels of 25, 21 and 20 pmol/L respectively which are within age related reference intervals for AMH [10].…”

Section: Factors Known To Affect Amh Levels In Adult Mensupporting

confidence: 66%

“…However, despite being a critical male hormone, vital in early male sexual differentiation, its physiologic role and the factors determining levels in adult men remain poorly understood [3,4]. It appears that AMH be a marker of Sertoli cell number and function but new reports suggest a broader role for this "gonadal cytokine" in men [5,6]. Laboratories providing measurement of male AMH should understand factors affecting levels in men so that they can provide appropriate clinical interpretation of results for clinicians.…”

Section: Introductionmentioning

confidence: 99%

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Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

Hadlow¹,

Hamilton²,

Joseph³

et al. 2017

Clin Med Biochemistry

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Aim: To assess if testosterone therapy, with suppression of LH and FSH altered AMH levels in men. Study background:AMH is an important male hormone and is increasingly measured by laboratories for men and women's health assessments. This prospective study was conducted in community medical centres to assess the effects of testosterone on AMH levels in men.Methods: Men (n=15) with androgen deficiency symptoms, who were prescribed a trial of testosterone therapy by their own practitioner for at least 6 months, consented to participate in a study measuring AMH pre-therapy and post-therapy. Testosterone therapy was given to achieve LH and FSH suppression. Measurement of testosterone, LH, FSH and AMH at baseline and post testosterone therapy on at least 2 occasions including at 6 months was completed in all men. Men with abnormal baseline biochemistry (elevated LH or testosterone below age appropriate ranges) were excluded (n=5) from further study. Results:In the study group baseline LH was normal (<8 U/L) and baseline testosterone was 7-23 (mean 12 nmol/L) and within age specific intervals. Mean baseline AMH was 36 pmol/L (range 19-89) and within age related intervals. A significant rise (p=0.001) of at least 1.5-fold in testosterone occurred post treatment (range 1.5-7.5-fold increase) with suppression of LH to <1 U/L with therapy. AMH showed variable changes after testosterone. There was no significant trend in AMH either rising or falling compared to baseline and levels were not associated with testosterone (p=0.197) nor affected by the suppression of FSH or LH (p=0.683, 0.271 respectively). Conclusions:No significant pattern of change occurs in AMH in adult men at 6 months undergoing exogenous testosterone therapy. Laboratories do not need to adjust AMH reference intervals for effects of testosterone therapy in men with normal baseline LH and testosterone prior to therapy.

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Section: Factors Known To Affect Amh Levels In Adult Mensupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

Hadlow¹,

Hamilton²,

Joseph³

et al. 2017

Clin Med Biochemistry

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“…AMH continues to be produced by the testes until puberty and then decreases slowly to residual post-puberty values (Teixeira et al 2001). Serum AMH levels may be an appropriate marker of the function and maturation of Sertoli cells in the males and, as such, an indicator of spermatogenesis (Sinisi et al 2008, Tüttelmann et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Secretion of anti-Müllerian hormone in the Florida manatee Trichechus manatus latirostris, with implications for assessing conservation status

Wilson¹,

Reynolds

Wetzel³

et al. 2011

Endang. Species. Res.

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“…3,12-14 Serum AMH concentrations have been found to be significantly lower 15,16 or equal [17][18][19] in subfertile men compared with controls. Similarly, seminal AMH concentrations have been found to be significantly lower 11,[20][21][22][23] or equal 15 in subfertile men compared with fertile controls.…”

Section: The Role Of Inhibin B and Amh Basal Concentrationsmentioning

confidence: 99%

The Sertoli cell: Novel clinical potentiality

Iliadou¹,

Tsametis²,

Kaprara³

et al. 2015

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Anti-Müllerian hormone in men with normal and reduced sperm concentration and men with maldescended testes

Cited by 74 publications

References 40 publications

Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

Relationships between Anti-mullerian Hormone, Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Men on Testosterone Therapy

Secretion of anti-Müllerian hormone in the Florida manatee Trichechus manatus latirostris, with implications for assessing conservation status

The Sertoli cell: Novel clinical potentiality

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